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ClinicalTrials.gov 48 recruiting now early-phase tilt

Anatomic Stage III Breast Cancer AJCC v8: early-phase trial registry

48 of 85 indexed Anatomic Stage III Breast Cancer AJCC v8 trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #165 of 28,707 conditions by registered trial count.

85 US clinical trials · 48 currently recruiting · #165 of 28,707 conditions by registered trial count

Anatomic Stage III Breast Cancer AJCC v8: 85 US clinical trials tracked, 48 recruiting.

Anatomic Stage III Breast Cancer AJCC v8 is the subject of 85 registered US clinical trials on ClinicalTrials.gov, 48 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 43 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 14 of these trials.

Enrollment posture brief

Registry condition anatomic-stage-iii-breast-cancer-ajcc-v8

OPEN 48 | RECR 56% | LATE 8 | EARLY 43 | RANK #165 | SPON 14

Nearest open-share peer: MDS (57% recruiting · 23 trials)

Pancreatic Ductal Adenocarci65.9%Suicidal Ideation61.2%Anatomic Stage III Breas (this)Anatomic Stage III Breas (th…56%Anxiety Disorders49.4%Cataract23.5%
Open-enrollment share among volume-matched conditions near Anatomic Stage III Breast Cancer AJCC v8

Anatomic Stage III Breast Cancer AJCC v8 lists 48 open slots (56% of 85 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Anatomic Stage III Breast Cancer AJCC v8 on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Anatomic Stage III Breast Cancer AJCC v8 is recruiting above its size-band peers.

    48 of 85 indexed trials (56.5%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Anatomic Stage III Breast Cancer AJCC v8 research.

    National Cancer Institute (NCI) accounts for 14 of 85 trials (16.5%). 22 distinct sponsors appear on at least one study for this condition label.

  3. Typical Anatomic Stage III Breast Cancer AJCC v8 enrolment sits around 60 participants.

    Median target enrolment is 60 among the 85 trials that report a genuine target (sentinel values excluded). 50 of those (58.8%) plan for fewer than 100 participants.

  4. Anatomic Stage III Breast Cancer AJCC v8 research is mostly interventional.

    77 interventional and 8 observational studies make up this index (90.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 120Phase 223Phase 37Phase 41

Open and recent trials

85 total, page 2 of 2

ACTIVE NOT RECRUITING Phase 3 1,167 participants

Additional Support Program Via Text Messaging and Telephone-Based Counseling for Breast Cancer Patients Receiving Hormonal Therapy

Alliance for Clinical Trials in Oncology

NCT04379570

ACTIVE NOT RECRUITING Phase 2 1,100 participants

Genetic Testing in Predicting Tumor Response in Patients With Stage I-III HER2 Negative Invasive Breast Cancer

M.D. Anderson Cancer Center

NCT01334021

ACTIVE NOT RECRUITING Phase 3 1,056 participants

T-DM1 and Tucatinib Compared With T-DM1 Alone in Preventing Relapses in People With High Risk HER2-Positive Breast Cancer, the CompassHER2 RD Trial

Alliance for Clinical Trials in Oncology

NCT04457596

ACTIVE NOT RECRUITING Phase 3 608 participants

Exemestane With or Without Entinostat in Treating Patients With Recurrent Hormone Receptor-Positive Breast Cancer That is Locally Advanced or Metastatic

National Cancer Institute (NCI)

NCT02115282

ACTIVE NOT RECRUITING NA 565 participants

Monitoring Symptoms to Help Young Women Take Hormone Therapy for Stage I-III Breast Cancer, ASPEN Study

SWOG Cancer Research Network

NCT05568472

ACTIVE NOT RECRUITING NA 543 participants

Improving Patient-Centered Communication in Breast Cancer Through Patient and Provider Interventions

Alliance for Clinical Trials in Oncology

NCT04549571

ACTIVE NOT RECRUITING NA 400 participants

Web-Based Symptom Monitoring and Self-Management Portal (YES) for Adolescent and Young Adult Breast Cancer Survivors

Ohio State University Comprehensive Cancer Center

NCT04906200

ACTIVE NOT RECRUITING NA 332 participants

A Text-based Intervention in Improving Adherence to Hormone Therapy in Patients With Stage I-III Hormone Receptor Positive Breast Cancer

Thomas Jefferson University

NCT04086875

ACTIVE NOT RECRUITING NA 256 participants

Culturally Based Brief Expressive Writing Intervention for the Improvement of Health in Chinese Immigrant Stage 0-III Breast Cancer Survivors, Writing to Heal Study

M.D. Anderson Cancer Center

NCT04754412

ACTIVE NOT RECRUITING Phase 2 249 participants

Taxane and Taxane-Induced Peripheral Neuropathy in African American Patients With Stage I-III Breast Cancer

ECOG-ACRIN Cancer Research Group

NCT04001829

ACTIVE NOT RECRUITING Phase 2 235 participants

Testing the Role of FDG-PET/CT to Predict Response to Therapy Prior to Surgery for HER2-positive Breast Cancer, The DIRECT Trial

ECOG-ACRIN Cancer Research Group

NCT05710328

ACTIVE NOT RECRUITING Phase 3 146 participants

Phase III Study of 5tx vs 15tx of RT (X-rays or Protons) Including RNI in Breast Cancer Patients

Mayo Clinic

NCT04443413

ACTIVE NOT RECRUITING NA 95 participants

Identifying Decision Making Needs for Older Adult Women With Stage I-III Breast Cancer Considering Neoadjuvant or Adjuvant Chemotherapy

M.D. Anderson Cancer Center

NCT05049746

ACTIVE NOT RECRUITING Phase 2 81 participants

Testing Olaparib Either Alone or in Combination With Atezolizumab in BRCA Mutant Non-HER2-positive Breast Cancer

National Cancer Institute (NCI)

NCT02849496

ACTIVE NOT RECRUITING NA 61 participants

Intensity Modulated Radiation Therapy or 3-Dimensional Conformal Radiation Therapy in Treating Patients With Lymph-Node Positive Breast Cancer

Ohio State University Comprehensive Cancer Center

NCT03786354

ACTIVE NOT RECRUITING NA 60 participants

A Conversational Agent (Cecebot) to Improve Insomnia in Stage I-III Breast Cancer Survivors

University of Washington

NCT06392789

ACTIVE NOT RECRUITING Phase 1 57 participants

Entinostat, Nivolumab, and Ipilimumab in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery or Locally Advanced or Metastatic HER2-Negative Breast Cancer

National Cancer Institute (NCI)

NCT02453620

ACTIVE NOT RECRUITING NA 49 participants

Mindfulness Intervention for Improving Nutrition in the Digital Kitchen Among Stage I-III Breast Cancer Survivors, MIND Trial

Fred Hutchinson Cancer Center

NCT06643455

ACTIVE NOT RECRUITING Phase 2 33 participants

STEMVAC in Patients With Early Stage Triple Negative Breast Cancer

University of Washington

NCT05455658

ACTIVE NOT RECRUITING Phase 2 30 participants

A Precision Medicine Approach (SMMART-ACT) for the Treatment of Patients With Advanced Sarcoma, Prostate, Breast, Ovarian or Pancreatic Cancer

OHSU Knight Cancer Institute

NCT06630325

ACTIVE NOT RECRUITING NA 30 participants

Exercise During Chemotherapy in Older Women With Stage I-III Breast Cancer

M.D. Anderson Cancer Center

NCT05025059

ACTIVE NOT RECRUITING Phase 1 24 participants

Testing the Addition of Copanlisib to Eribulin in Metastatic Triple Negative Breast Cancer

National Cancer Institute (NCI)

NCT04345913

ACTIVE NOT RECRUITING Phase 1 23 participants

PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot Be Removed by Surgery

National Cancer Institute (NCI)

NCT03218826

ACTIVE NOT RECRUITING Phase 1 18 participants

Niraparib and TSR-042 for the Treatment of BRCA-Mutated Unresectable or Metastatic Breast, Pancreas, Ovary, Fallopian Tube, or Primary Peritoneal Cancer

University of Washington

NCT04673448

ACTIVE NOT RECRUITING Phase 2 17 participants

TVB-2640 and Trastuzumab With Paclitaxel or Endocrine Therapy for Treatment of HER2 Positive Metastatic Breast Cancer

Mayo Clinic

NCT03179904

ACTIVE NOT RECRUITING Phase 2 8 participants

Estradiol in Treating Patients With ER Beta Positive, Triple Negative Locally Advanced or Metastatic Breast Cancer

Mayo Clinic

NCT03941730

COMPLETED NA 452 participants

Tibetan Yoga in Improving Fatigue and Sleep in Participants With Stage I-III Breast Cancer

M.D. Anderson Cancer Center

NCT00507923

COMPLETED Phase 2 130 participants

Safely Stopping Pre-medications in Patients With Breast Cancer Who Are Receiving Paclitaxel

Ohio State University Comprehensive Cancer Center

NCT04862585

COMPLETED NA 50 participants

An Episodic Future Thinking Intervention to Promote Weight Loss in Breast Cancer Survivors

Ohio State University Comprehensive Cancer Center

NCT05012176

COMPLETED NA 45 participants

An Escape Room Intervention to Help Improve Breast Cancer Patients' Ability to Navigate Online Access to Nutrition Information

Fred Hutchinson Cancer Center

NCT06193070

COMPLETED NA 23 participants

Acupuncture in Reducing Chemotherapy-Induced Peripheral Neuropathy in Participants With Stage I-III Breast Cancer

Wake Forest University Health Sciences

NCT03505671

COMPLETED Phase 1 20 participants

M7824 in Treating Patients With Stage II-III HER2 Positive Breast Cancer

M.D. Anderson Cancer Center

NCT03620201

COMPLETED Phase 1 18 participants

Alpelisib and Enzalutamide in Treating Patients With Androgen Receptor and PTEN Positive Metastatic Breast Cancer

M.D. Anderson Cancer Center

NCT03207529

COMPLETED Phase 1 15 participants

Hydroxychloroquine, Palbociclib, and Letrozole Before Surgery in Treating Patients With Estrogen Receptor Positive, HER2 Negative Breast Cancer

M.D. Anderson Cancer Center

NCT03774472

COMPLETED Phase 1 11 participants

Nilotinib in Preventing Paclitaxel-Induced Peripheral Neuropathy in Patients With Stage I-III Breast Cancer

Ohio State University Comprehensive Cancer Center

NCT04205903

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Phase Distribution

PhaseTrial count
Phase 1 20
Phase 2 23
Phase 3 7
Phase 4 1

Named interventions

Most-linked intervention names on Anatomic Stage III Breast Cancer AJCC v8 records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Biospecimen Collection Procedure
29 trials
Questionnaire Administration Other
27 trials
Computed Tomography Procedure
14 trials
Quality-of-Life Assessment Other
13 trials
Biopsy Procedure Procedure
10 trials
Best Practice Other
9 trials
Educational Intervention Other
7 trials
Survey Administration Other
7 trials

US sites by state

Facility locations filed on Anatomic Stage III Breast Cancer AJCC v8 trials. A trial with sites in several states counts in each.

California 28 trials
Texas 17 trials
Ohio 15 trials
Florida 15 trials
Arizona 14 trials
Washington 10 trials
Alabama 10 trials
Arkansas 8 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Anatomic Stage III Breast Cancer AJCC v8 page

85 registered trials, 48 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

  • 48 Anatomic Stage III Breast Cancer AJCC v8 trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
  • National Cancer Institute (NCI) sponsors the most Anatomic Stage III Breast Cancer AJCC v8 trials on record, review their full trial history before evaluating a specific study. See National Cancer Institute (NCI)'s trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Anatomic Stage III Breast Cancer AJCC v8 condition card totals 85 registered trials; most-linked intervention Biospecimen Collection; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.