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ClinicalTrials.gov 48 recruiting now official registry

Anatomic Stage III Breast Cancer AJCC v8 clinical trials

48 of 85 indexed Anatomic Stage III Breast Cancer AJCC v8 trials are currently recruiting.

85 US clinical trials · 48 currently recruiting

Anatomic Stage III Breast Cancer AJCC v8 is the subject of 85 registered US clinical trials on ClinicalTrials.gov, 48 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 43 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 14 of these trials.

The research picture

Anatomic Stage III Breast Cancer AJCC v8 has 85 registered US clinical trials, 48 of them open to new participants right now, about 56% of the total.

48
recruiting participants now
56%
of trials open to enrollment
8
in Phase 3–4 (later-stage)
14
top sponsor: National Cancer Institute (NCI)
Phase 120Phase 223Phase 37Phase 41

Active & Recent Trials

85 total, page 1 of 2

RECRUITING Phase 3 3,680 participants

Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer

National Cancer Institute (NCI)

NCT06058377

RECRUITING Phase 2 2,900 participants

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

National Cancer Institute (NCI)

NCT05564377

RECRUITING 1,600 participants

National Cancer Institute "Cancer Moonshot Biobank"

National Cancer Institute (NCI)

NCT04314401

RECRUITING 1,300 participants

Breast Cancer Survivorship Biorepository

University of Southern California

NCT05786664

RECRUITING Phase 3 1,295 participants

Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab

Alliance for Clinical Trials in Oncology

NCT05812807

RECRUITING NA 640 participants

Remotely Delivered, Community-Aligned Weight Loss Interventions Among Breast Cancer Survivors, ¡Vida! Trial

Fred Hutchinson Cancer Center

NCT05930483

RECRUITING NA 252 participants

Lymphovenous Bypass Procedure Before Underarm Lymph Node Surgery in Preventing Lymphedema in Patients With Inflammatory or Locally Advanced Non-inflammatory Breast Cancer or Melanoma

M.D. Anderson Cancer Center

NCT03941756

RECRUITING 250 participants

Social Health, Activity Behaviors, and Quality of Life Among Young Adult Cancer Survivors

University of Southern California

NCT07259304

RECRUITING 230 participants

Immune Response to Anti-HER2 Therapies in Patients With HER2-Positive Stage I-IV Breast Cancer

Mayo Clinic

NCT04517838

RECRUITING Phase 3 200 participants

Metformin for the Treatment of Insulin Resistance in Women With Stage I-III Breast Cancer Completing Chemotherapy

City of Hope Medical Center

NCT06763328

RECRUITING Phase 2 200 participants

Prediction of Neoadjuvant Chemotherapy Response Using Contrast-Enhanced Ultrasound in Patients With Locally Advanced Breast Cancer

Kibo Nam

NCT04715958

RECRUITING Phase 2 174 participants

Dose-Reduced Docetaxel With Cyclophosphamide for the Treatment of Vulnerable Older Women With Stage I-III HER2 Negative Breast Cancer, the DOROTHY Trial

City of Hope Medical Center

NCT06042569

RECRUITING Phase 2 164 participants

Prevention of Frailty With Fisetin and Exercise in Breast Cancer Survivors

Jonsson Comprehensive Cancer Center

NCT06113016

RECRUITING NA 150 participants

Acutherapy to Prevent Aromatase Inhibitor-Associated Arthralgias in Non-Hispanic Black Postmenopausal Women With Early-Stage Breast Cancer

Emory University

NCT06534125

RECRUITING Phase 1 132 participants

Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors

Mayo Clinic

NCT05269381

RECRUITING Phase 2 120 participants

Hypofractionated Radiotherapy Before or After Breast Surgery for Treatment of Patients With Non-Metastatic Breast Cancer

Mayo Clinic

NCT06635980

RECRUITING NA 108 participants

Integrative Approaches for Cancer Survivorship (IACS3)

University of California, San Francisco

NCT06633926

RECRUITING Phase 1 100 participants

The Immune Effects of Fermented Wheat Germ Nutritional Supplementation in Patients With Advanced Solid Tumor Cancers Being Treated With Standard of Care Checkpoint Inhibitors

University of California, Davis

NCT05967533

RECRUITING 100 participants

The Sleep After Breast Cancer (ABC) Study - Examining Sleep Changes and Biomarkers Among Breast Cancer Patients

Ohio State University Comprehensive Cancer Center

NCT07341503

RECRUITING Phase 2 88 participants

Fisetin to Improve Physical Function in Stage I-III Breast Cancer Survivors

Jonsson Comprehensive Cancer Center

NCT05595499

RECRUITING Phase 2 82 participants

Ultra-hypofractionated Whole Breast Irradiation With Lumpectomy Cavity Boost for the Treatment of Stage I-III Breast Cancer

City of Hope Medical Center

NCT06954831

RECRUITING Phase 2 75 participants

Leuprolide and Goserelin for Ovarian Function Suppression in Pre- or Peri-menopausal Women With Breast Cancer, OFS Trial

University of Michigan Rogel Cancer Center

NCT07158021

RECRUITING Phase 4 68 participants

Effect of HSD3B1 (1245C) Gene Mutation on Treatment of Stage I-III Breast Cancer

University of Washington

NCT05183828

RECRUITING NA 60 participants

Food for Thought - A Nutrition Intervention for Women Undergoing Active Treatment for Triple Negative Breast Cancer

Ohio State University Comprehensive Cancer Center

NCT06582615

RECRUITING Phase 2 60 participants

Functional Imaging in Prediction of Response to Abemaciclib for Advanced Hormone Receptor-Positive, HER2-Negative Breast Cancer

University of Washington

NCT06179303

RECRUITING Phase 2 60 participants

Olaparib With Cediranib or AZD6738 for the Treatment of Advanced or Metastatic Germline BRCA Mutated Breast Cancer

M.D. Anderson Cancer Center

NCT04090567

RECRUITING Phase 1 57 participants

Testing the Addition of Anti-Cancer Drug, ZEN003694 (ZEN-3694) and PD-1 Inhibitor (Pembrolizumab), to Standard Chemotherapy (Nab-Paclitaxel) Treatment in Patients With Advanced Triple-Negative Breast Cancer

National Cancer Institute (NCI)

NCT05422794

RECRUITING NA 55 participants

Neoadjuvant Breast Cancer Time Restricted Eating

Thomas Jefferson University

NCT05327608

RECRUITING Phase 1 51 participants

Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Advanced Solid Tumors Expressing the HER2 Protein or Gene, The DASH Trial

National Cancer Institute (NCI)

NCT04704661

RECRUITING Early Phase 1 50 participants

Topical or Oral Minoxidil for the Treatment of Endocrine Therapy-Induced Alopecia in Patients With Stage I-IV Breast Cancer

Ohio State University Comprehensive Cancer Center

NCT05417308

RECRUITING Phase 1 45 participants

Testing the Safety and Efficacy of the Combination of Two Anti-cancer Drugs, ZEN003694 and Abemaciclib, for Adult and Pediatric Patients (12-17 Years) With Metastatic or Unresectable NUT Carcinoma, Breast Cancer and Other Solid Tumors

National Cancer Institute (NCI)

NCT05372640

RECRUITING NA 40 participants

A Quality of Life Intervention for Young African American Breast Cancer Survivors in Treatment

University of Alabama at Birmingham

NCT05243056

RECRUITING NA 40 participants

Feasibility Study of Biobehavioral Stress Reduction Intervention in Patients With Triple Negative Breast Cancer

Ohio State University Comprehensive Cancer Center

NCT05677802

RECRUITING Early Phase 1 40 participants

Letrozole With and Without Simvastatin for the Treatment of Stage I-III Hormone Receptor Positive, HER2 Negative Breast Cancer

Emory University

NCT05464810

RECRUITING Phase 2 38 participants

5-strain Probiotic Formulation in HR-positive Breast Cancer Receiving Aromatase Inhibitor to Prevent Bone Loss

Mayo Clinic

NCT07044310

RECRUITING Phase 1 36 participants

Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer

National Cancer Institute (NCI)

NCT07137416

RECRUITING Phase 2 36 participants

Measuring the Effects of Talazoparib in Patients With Advanced Cancer and DNA Repair Variations

National Cancer Institute (NCI)

NCT04550494

RECRUITING Phase 1 32 participants

Testing the Addition of an Anti-cancer Drug, ASTX727 (Cedazuridine, Decitabine), to Chemotherapy (Paclitaxel) and Immunotherapy (Pembrolizumab) for Metastatic Triple-Negative Breast Cancer

National Cancer Institute (NCI)

NCT05673200

RECRUITING Phase 2 30 participants

Tamoxifen and Pegylated Liposomal Doxorubicin for the Treatment of Patients With Metastatic or Inoperable, Locally Advanced Triple Negative Breast Cancer

Roswell Park Cancer Institute

NCT06434064

RECRUITING NA 30 participants

Geriatric Care Survivorship Intervention for Improving the Overall Health of Older Adults With Stage I-III Breast Cancer Who Have Completed Curative Treatment

M.D. Anderson Cancer Center

NCT05928325

RECRUITING NA 30 participants

Piloting Y-AMBIENT: A Quality of Life Intervention for Young African American Breast Cancer Survivors

University of Alabama at Birmingham

NCT05452681

RECRUITING NA 27 participants

Transcutaneous Electrical Nerve Stimulation in Chemotherapy Induced Peripheral Neuropathy in Patients With Stage I-III Early Stage Breast Cancer

Emory University

NCT05368428

RECRUITING Phase 2 25 participants

Concurrent WOKVAC Vaccination, Chemotherapy, and HER2-Targeted Monoclonal Antibody Therapy Before Surgery for the Treatment of Patients With Breast Cancer

University of Washington

NCT04329065

RECRUITING 25 participants

Enhancing Skin Appearance and Quality of Life in Breast Cancer Survivors on Aromatase Inhibitor Therapy

Mayo Clinic

NCT06401889

RECRUITING Phase 1 20 participants

An Optimized Ultrasound Twinkling Marker for the Imaging of Lymph Nodes in Patients With Clinically Node-Positive Breast Cancer, The UTMOST2 Trial

Mayo Clinic

NCT06999798

RECRUITING Phase 1 18 participants

Personalized Vaccine Immunotherapy in Combination With Checkpoint Inhibitor for Treatment of Triple Negative Breast Cancer

Emory University

NCT06324240

RECRUITING Phase 1 18 participants

Ribociclib, Tucatinib, and Trastuzumab for the Treatment of HER2 Positive Breast Cancer

Jonsson Comprehensive Cancer Center

NCT05319873

RECRUITING NA 15 participants

Decision Making Tool in Supporting Decision Making in Contralateral Prophylactic Mastectomy in Patients With Newly Diagnosed Breast Cancer

M.D. Anderson Cancer Center

NCT02918474

ACTIVE NOT RECRUITING 1,410 participants

Infertility Survey Among Reproductive Age Women With Gynecological and Breast Cancer

M.D. Anderson Cancer Center

NCT04678414

ACTIVE NOT RECRUITING 1,336 participants

Treatment Effects on Development of Chemotherapy-Induced Peripheral Neuropathy in Patients With Cancer

SWOG Cancer Research Network

NCT03939481

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Phase Distribution

PhaseTrial count
Phase 1 20
Phase 2 23
Phase 3 7
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Anatomic Stage III Breast Cancer AJCC v8 Trial Landscape

85 indexed Anatomic Stage III Breast Cancer AJCC v8 studies · 48 recruiting (56%).

Phase mix: 8 late (III/IV) vs 43 early (I/II).

Top sponsor: National Cancer Institute (NCI) (14 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Anatomic Stage III Breast Cancer AJCC v8?

PlainTrial tracks 85 US clinical trials for Anatomic Stage III Breast Cancer AJCC v8, of which 48 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Anatomic Stage III Breast Cancer AJCC v8?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.