Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 1

DCSZ11 as a Monotherapy and in Combination in Patients With Advanced or Metastatic Solid Tumors

NCT05785754 · View on ClinicalTrials.gov ↗

Study Summary

This is a multicenter, open-label, Phase 1 study to assess the effects of DCSZ11 as a monotherapy and in combination in patients with advanced or metastatic solid tumors. The study consists of an Escalation Phase (Phase 1a) and a Dose Expansion/Optimization Phase (Phase 1b).

Interventions

  • DRUG Pembrolizumab
  • DRUG Doxorubicin
  • DRUG Tebentafusp
  • DRUG DCSZ11

Study Locations (20)

Arizona

  • Mayo Clinic — Phoenix
  • HonorHealth — Scottsdale

Colorado

  • University of Colorado — Aurora
  • Sarah Cannon Research Institute Denver Healthone — Denver

Florida

  • Mayo Clinic — Jacksonville
  • University of Miami — Miami

New South Wales

  • Scientia Clinical Research — Randwick
  • St Vincent's Hospital — Sydney

South Australia

  • Southern Oncology Clinical Research Unit (SOCRU) — Bedford Park
  • The Queen Elizabeth Hospital (TQEH) — Woodville South

Alabama

  • University of Alabama — Birmingham

Connecticut

  • Yale Cancer Center — New Haven

Maryland

  • John Hopkins Sidney Kimmel Comprehensive Cancer Center — Baltimore

Trial Details

FieldValue
Enrollment Target 320 participants
Start Date 2023-06-28
Est. Completion 2026-12
Phase Phase 1

Sponsor

DynamiCure Biotechnology

1 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05785754

The ClinicalTrials.gov registry entry for NCT05785754 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 320 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is DynamiCure Biotechnology, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Advanced or Metastatic Solid Tumors appearing as the primary indexed condition, and to 4 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05785754 reports 20 study locations spanning 15 distinct geographic areas — top geographies include Arizona, Colorado, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05785754 about?

NCT05785754 is a clinical study titled "DCSZ11 as a Monotherapy and in Combination in Patients With Advanced or Metastatic Solid Tumors". This is a multicenter, open-label, Phase 1 study to assess the effects of DCSZ11 as a monotherapy and in combination in patients with advanced or metastatic solid tumors. The study consists of an Escalation Phase (Phase 1a) and a Dose Expansion/Optimization Phase (Phase 1b).

What is the current status of trial NCT05785754?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 320 participants. The study started on 2023-06-28. Estimated completion is 2026-12.

What conditions does trial NCT05785754 study?

This clinical trial studies the following conditions: Advanced or Metastatic Solid Tumors. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05785754?

The interventions under investigation include: Pembrolizumab (DRUG), Doxorubicin (DRUG), Tebentafusp (DRUG), DCSZ11 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05785754?

This trial is sponsored by DynamiCure Biotechnology, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05785754 being conducted?

This trial has 20 study locations across Alabama, Arizona, Colorado, Connecticut, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial