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ClinicalTrials.gov 9 recruiting now official registry

Advanced Hepatocellular Carcinoma clinical trials

9 of 17 indexed Advanced Hepatocellular Carcinoma trials are currently recruiting.

17 US clinical trials · 9 currently recruiting

Advanced Hepatocellular Carcinoma is the subject of 17 registered US clinical trials on ClinicalTrials.gov, 9 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 2 of these trials.

The research picture

Advanced Hepatocellular Carcinoma has 17 registered US clinical trials, 9 of them open to new participants right now, about 53% of the total.

9
recruiting participants now
53%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
2
top sponsor: National Cancer Institute (NCI)
Phase 18Phase 27Phase 32

Active & Recent Trials

17 total, page 1 of 1

RECRUITING Phase 3 252 participants

Testing Immunotherapy With or Without Stereotactic Body Radiation Therapy in Patients With Advanced Liver Cancer, HELIO-RT Trial

NRG Oncology

NCT07166406

RECRUITING Phase 1 178 participants

A Study of Tegavivint (BC2059) in Patients With Advanced Hepatocellular Carcinoma

Iterion Therapeutics

NCT05797805

RECRUITING Phase 1 158 participants

A Study to Evaluate ALN-BCAT in Patients With Hepatocellular Carcinoma

Alnylam Pharmaceuticals

NCT06600321

RECRUITING Phase 1 92 participants

Testing the Addition of an Anti-cancer Drug, Sapanisertib, to the Usual Chemotherapy Treatment (Cabozantinib) in Metastatic Liver Cell Cancer With a Change in Genes for the Protein β-Catenin, The SAPHIRE Trial

National Cancer Institute (NCI)

NCT06811116

RECRUITING Phase 2 64 participants

Ligufalimab and Cadonilimab in Advanced Liver Cancers

University of Texas Southwestern Medical Center

NCT06789848

RECRUITING Phase 1 43 participants

Phase I Study of Tumor Treating Fields (TTF) in Combination With Cabozantinib or With Pembrolizumab and Nab-Paclitaxel in Patients With Advanced Solid Tumors Involving the Abdomen or Thorax

M.D. Anderson Cancer Center

NCT05092373

RECRUITING Phase 2 39 participants

Celecoxib, Durvalumab and Tremelimumab for the Treatment of Patients With Advanced or Metastatic Liver Cancer

Emory University

NCT07174570

RECRUITING Phase 1 36 participants

AU409 for the Treatment of Advanced Primary Liver Cancers or Solid Tumor With Liver Metastatic Disease

University of Southern California

NCT05791448

RECRUITING Phase 2 21 participants

Durvalumab With/Without Tremelimumab After Palliative Hypofractionated Radiotherapy for Hepatocellular Carcinoma

Mary Feng, MD

NCT04430452

ACTIVE NOT RECRUITING Phase 3 111 participants

Durvalumab and Tremelimumab as First Line Treatment in Participants With Advanced Hepatocellular Carcinoma (HCC)

AstraZeneca

NCT05883644

ACTIVE NOT RECRUITING Phase 1 8 participants

Testing the Combination of the Anti-cancer Drugs XL184 (Cabozantinib) and Nivolumab in Patients With Advanced Cancer and HIV

National Cancer Institute (NCI)

NCT04514484

COMPLETED Phase 2 172 participants

CS1008- in Combination With Sorafenib Compared to Sorafenib Alone in Subjects With Advanced Liver Cancer

Daiichi Sankyo

NCT01033240

COMPLETED Phase 1 128 participants

Phase 1 Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of H3B-6527 in Participants With Advanced Hepatocellular Carcinoma

H3 Biomedicine

NCT02834780

COMPLETED Phase 2 44 participants

Phase 2 Study of ABT-869 in Advanced Hepatocellular Carcinoma (HCC)

AbbVie (prior sponsor, Abbott)

NCT00517920

COMPLETED Phase 2 29 participants

68Ga PSMA PET Imaging for the Treatment of Advanced Liver Cancer

Mayo Clinic

NCT05176223

COMPLETED Phase 2 23 participants

A Clinical Research Study to Determine Whether PD 0332991 May Be Effective in Treating Patients With Liver Cancer

Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

NCT01356628

COMPLETED Phase 1 3 participants

Siliphos in Advanced Hepatocellular Carcinoma

Abby Siegel

NCT01129570

Phase Distribution

PhaseTrial count
Phase 1 8
Phase 2 7
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Advanced Hepatocellular Carcinoma Trial Landscape

17 indexed Advanced Hepatocellular Carcinoma studies · 9 recruiting (53%).

Phase mix: 2 late (III/IV) vs 15 early (I/II).

Top sponsor: National Cancer Institute (NCI) (2 trials), 9 others listed. 17 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Advanced Hepatocellular Carcinoma?

PlainTrial tracks 17 US clinical trials for Advanced Hepatocellular Carcinoma, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Advanced Hepatocellular Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.