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NCT05797805 · ClinicalTrials.gov registry record · Phase 1
A Study of Tegavivint (BC2059) in Patients With Advanced Hepatocellular Carcinoma
A Phase 1 study of Advanced Hepatocellular Carcinoma, sponsored by Iterion Therapeutics.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 178
- Enrollment target
- 8
- Study locations
NCT05797805: Recruiting Phase 1 study of Advanced Hepatocellular Carcinoma, sponsored by Iterion Therapeutics.
NCT05797805 is a Phase 1 study of Advanced Hepatocellular Carcinoma that is actively recruiting participants, run by Iterion Therapeutics. The registered enrollment target is 178 participants, above the 76-participant average among 16 other Advanced Hepatocellular Carcinoma trials with a reported enrollment target (134% higher). The trial reports 8 study locations across 7 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05797805, a Phase 1 study of Advanced Hepatocellular Carcinoma, is actively recruiting participants, sponsored by Iterion Therapeutics.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 178 participants
- Enrollment target
- 8
- Study locations
Study Summary
This study will be conducted in 2 parts. The first part is a phase 1 single-agent dose escalation, and dose optimization, study of tegavivint in patients with advanced HCC after failure of at least one line of prior systemic therapy. The second part of the study will begin with a brief dose escalation part for each combination (tegavivint plus cabozantinib or tegavivint plus lenvatinib) followed by a combination dose expansion.
Primary Outcome
Adverse events will be assessed according to the NCI-CTCAE version 5.0
Conditions Studied
Interventions
- DRUG Cabozantinib
- DRUG Lenvatinib
- DRUG Tegavivint
Study Locations (8)
Texas
- UT Southwestern - Dallas
- MD Anderson Cancer Center - Houston
California
- City of Hope - Duarte
Florida
- Sylvester Comprehensive Cancer Center - Miami
Illinois
- University of Chicago - Chicago
North Carolina
- Levine Cancer Institute - Charlotte
Washington
- Fred Hutchinson Cancer Center - Seattle
Ontario
- UHN - Princess Margaret Cancer Centre - Toronto
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 178 participants |
| Start Date | 2023-09-13 |
| Est. Completion | 2026-06 |
| Phase | Phase 1 |
What NCT05797805 shows while recruiting
NCT05797805 is an interventional study that assigns participants to a tested intervention. The registered 178 participants enrollment target is mid-sized for trials with a published cap, above the 76-participant average among 16 other Advanced Hepatocellular Carcinoma trials with a reported enrollment target (134% higher).
The record links to 1 condition, with Advanced Hepatocellular Carcinoma appearing as the primary indexed condition, and to 3 interventions - of which Cabozantinib is the first listed.
NCT05797805 lists 8 locations in 7 states (Texas, California, Florida).
Frequently Asked Questions
What is clinical trial NCT05797805 about?
NCT05797805 is a clinical study titled "A Study of Tegavivint (BC2059) in Patients With Advanced Hepatocellular Carcinoma". This study will be conducted in 2 parts. The first part is a phase 1 single-agent dose escalation, and dose optimization, study of tegavivint in patients with advanced HCC after failure of at least one line of prior systemic therapy. The second part of the study will begin with a brief dose escalati...
What is the current status of trial NCT05797805?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 178 participants. The study started on 2023-09-13. Estimated completion is 2026-06.
What conditions does trial NCT05797805 study?
This clinical trial studies the following conditions: Advanced Hepatocellular Carcinoma.
What interventions are being tested in trial NCT05797805?
The interventions under investigation include: Cabozantinib (DRUG), Lenvatinib (DRUG), Tegavivint (DRUG).
Who is sponsoring clinical trial NCT05797805?
This trial is sponsored by Iterion Therapeutics, which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05797805 being conducted?
This trial has 8 study locations across California, Florida, Illinois, North Carolina, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Advanced Hepatocellular Carcinoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05797805's enrollment target sits among peer trials
178 2nd of 16 the highest of 16 other Advanced Hepatocellular Carcinoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Advanced Hepatocellular Carcinoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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