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ClinicalTrials.gov 5 recruiting now official registry

Alzheimer Disease, Early Onset clinical trials

Every US clinical trial registered for Alzheimer Disease, Early Onset — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

12 US clinical trials · 5 currently recruiting

The research picture

Alzheimer Disease, Early Onset has 12 registered US clinical trials, 5 of them open to new participants right now — about 42% of the total.

5
recruiting participants now
42%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
1
top sponsor: Pain Therapeutics

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 10,000 participants

NYSCF Scientific Discovery Biobank

New York Stem Cell Foundation Research Institute

NCT06203106

RECRUITING NA 90 participants

Effects of Electrical Stimulation on Verbal Learning in Typical and Atypical Alzheimer's Disease

Johns Hopkins University

NCT04122001

RECRUITING NA 60 participants

Lifestyle Interventions for the Treatment of Early Onset Alzheimer's Disease Study

Indiana University

NCT05573490

RECRUITING NA 50 participants

Chronic Treatment of Alzheimer's Disease by Gamma Light and Sound Therapy

Massachusetts Institute of Technology

NCT05655195

RECRUITING Phase 1 35 participants

Repurposing Nucleoside Reverse Transcriptase Inhibitors for Treatment of AD

Butler Hospital

NCT04500847

ACTIVE NOT RECRUITING NA 670 participants

A Pivotal Study of Sensory Stimulation in Alzheimer's Disease (Hope Study, CA-0011)

Cognito Therapeutics

NCT05637801

ACTIVE NOT RECRUITING Phase 2 310 participants

Study to Evaluate the Efficacy, Safety, and Tolerability of an Anti-MTBR Tau Monoclonal Antibody (BMS-986446) in Participants With Early Alzheimer's Disease

Bristol-Myers Squibb

NCT06268886

ACTIVE NOT RECRUITING Phase 1 144 participants

PMN310 in Patients With Early Alzheimer's Disease (PRECISE-AD)

ProMis Neurosciences

NCT06750432

ACTIVE NOT RECRUITING NA 60 participants

Molecular and Structural Imaging in Alzheimer's Disease: A Longitudinal Study

Mayo Clinic

NCT02740634

ACTIVE NOT RECRUITING Phase 2 48 participants

Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD) Study

Washington University School of Medicine

NCT04685590

COMPLETED 4,884 participants

Genetic Studies in Familial Dementia

University of Miami

NCT04680013

COMPLETED Phase 1 24 participants

A Safety Study of PTI-125 in Healthy Volunteers

Pain Therapeutics

NCT03784300

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Alzheimer Disease, Early Onset Trial Landscape

ClinicalTrials.gov lists 12 US studies indexed under Alzheimer Disease, Early Onset, and 5 of those are currently open to recruitment — roughly 42% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Alzheimer Disease, Early Onset shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 5 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Alzheimer Disease, Early Onset is led by Pain Therapeutics with 1 indexed trial, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 12 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Alzheimer Disease, Early Onset?

PlainTrial tracks 12 US clinical trials for Alzheimer Disease, Early Onset, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Alzheimer Disease, Early Onset?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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