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ClinicalTrials.gov 11 recruiting now early-phase tilt small index

Acute Myeloid Leukemia Refractory: early-phase trial registry

11 of 13 indexed Acute Myeloid Leukemia Refractory trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #1,315 of 28,707 conditions by registered trial count.

13 US clinical trials · 11 currently recruiting · #1,315 of 28,707 conditions by registered trial count

Acute Myeloid Leukemia Refractory: 13 US clinical trials tracked, 11 recruiting.

Acute Myeloid Leukemia Refractory is the subject of 13 registered US clinical trials on ClinicalTrials.gov, 11 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 13 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 2 of these trials.

Enrollment posture brief

Registry condition acute-myeloid-leukemia-refractory

OPEN 11 | RECR 85% | LATE 0 | EARLY 13 | RANK #1315 | SPON 2

Nearest open-share peer: Blood Cancer (85% recruiting · 13 trials)

Acute Myeloid Leukemia R (th…85%ACL Injury61.5%Acute Biphenotypic Leukemia46.2%Accidental Falls30.8%Actinic Keratoses23.1%
Open-enrollment share among volume-matched conditions near Acute Myeloid Leukemia Refractory

Acute Myeloid Leukemia Refractory lists 11 open slots (85% of 13 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Acute Myeloid Leukemia Refractory on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Acute Myeloid Leukemia Refractory is recruiting above its size-band peers.

    11 of 13 indexed trials (84.6%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Acute Myeloid Leukemia Refractory research.

    Memorial Sloan Kettering Cancer Center accounts for 2 of 13 trials (15.4%). 12 distinct sponsors appear on at least one study for this condition label.

  3. Most Acute Myeloid Leukemia Refractory trials plan to enrol fewer than 100 people.

    Median target enrolment is 38 among the 13 trials that report a genuine target (sentinel values excluded). 12 of those (92.3%) plan for fewer than 100 participants.

  4. Acute Myeloid Leukemia Refractory research is mostly interventional.

    13 interventional and 0 observational studies make up this index (100% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 112Phase 21

Open and recent trials

13 total, page 1 of 1

RECRUITING Phase 1 100 participants

Study of REM-422 in Patients With AML or Higher Risk MDS

Remix Therapeutics

NCT06297941

RECRUITING Phase 1 78 participants

AB8939 in Patients With Relapsed/Refractory Acute Myeloid Leukemia

AB Science

NCT05211570

RECRUITING Phase 1 50 participants

Study of Iadademstat and Gilteritinib in Patients With R/R AML With FMS-like Tyrosine Kinase Mutation (FLT3 Mut+)

Oryzon Genomics S.A.

NCT05546580

RECRUITING Phase 1 49 participants

Clinical Study of ARD103 CAR-T Therapy for Patients With R/R AML or MDS

ARCE Therapeutics

NCT06680752

RECRUITING Phase 1 48 participants

A Clinical Trial of BP1002 in Patients With Refractory/Relapsed Acute Myeloid Leukemia (AML)

Bio-Path Holdings

NCT05190471

RECRUITING Phase 1 40 participants

Venetoclax to Augment Epigenetic Modification and Chemotherapy

Medical College of Wisconsin

NCT05317403

RECRUITING Phase 2 38 participants

Intensity Modulated Total Marrow Irradiation in Fully Human Leukocyte Antigen (HLA)-Matched and Partially-HLA Mismatched Allogeneic Transplantation Patients With High-Risk Acute Myeloid Leukemia (AML), Chronic Myeloid Leukemia (CML), and Myelodysplastic Syndrome (MDS)

University of Illinois at Chicago

NCT06802315

RECRUITING Phase 1 18 participants

A Study of Natural Killer Cells in Combination With Atezolizumab in People With Acute Myelogenous Leukemia

Memorial Sloan Kettering Cancer Center

NCT07011004

RECRUITING Phase 1 18 participants

PLAT-08: A Study Of SC-DARIC33 CAR T Cells In Pediatric And Young Adults With Relapsed Or Refractory CD33+ AML

Seattle Children's Hospital

NCT05105152

RECRUITING Phase 1 15 participants

A Study of CD371-YSNVZIL-18 CAR T Cells in People With Acute Myeloid Leukemia

Memorial Sloan Kettering Cancer Center

NCT06017258

RECRUITING Phase 1 15 participants

Study of C6 Ceramide NanoLiposome (CNL) in Patients With Relapsed/Refractory Acute Myeloid Leukemia

Keystone Nano

NCT04716452

ACTIVE NOT RECRUITING Phase 1 22 participants

Lentivirally Redirected CD123 Autologous T Cells in AML

University of Pennsylvania

NCT03766126

COMPLETED Phase 1 16 participants

KPT-9274 in Patients With Relapsed and Refractory Acute Myeloid Leukemia

University of Colorado, Denver

NCT04914845

Phase Distribution

PhaseTrial count
Phase 1 12
Phase 2 1

Named interventions

Most-linked intervention names on Acute Myeloid Leukemia Refractory records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Fludarabine Drug
2 trials
Venetoclax Drug
2 trials
KPT-9274 Drug
1 trials
CART123 cells; cyclophosphamide; fludarabine Biological
1 trials
ARD103 Biological
1 trials
Gilteritinib Oral Tablet Drug
1 trials
AB8939 Drug
1 trials
Decitabine (in combination with BP1002) Drug
1 trials

US sites by state

Facility locations filed on Acute Myeloid Leukemia Refractory trials. A trial with sites in several states counts in each.

New York 5 trials
Texas 4 trials
New Jersey 3 trials
Wisconsin 2 trials
North Carolina 2 trials
Massachusetts 2 trials
Florida 2 trials
California 2 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Acute Myeloid Leukemia Refractory page

13 registered trials, 11 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Acute Myeloid Leukemia Refractory condition card totals 13 registered trials; most-linked intervention Fludarabine; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.