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NCT07405515 · ClinicalTrials.gov registry record · NA
Pathophysiology of Dysautonomia and Postural Tachycardia Syndrome (POTS) in Post-viral Syndromes and COVID-19
A NA study of Autonomic Dysfunction and Dysautonomia, sponsored by Brigham and Women's Hospital.
- Active
- Registry status
- NA
- Development phase
- 100
- Enrollment target
- 1
- Study location
NCT07405515: Active NA study of Autonomic Dysfunction and Dysautonomia, sponsored by Brigham and Women's Hospital.
NCT07405515 is a NA study of Autonomic Dysfunction and Dysautonomia that is active but no longer recruiting, run by Brigham and Women's Hospital. The registered enrollment target is 100 participants, roughly in line with the 109-participant average among 8 other Autonomic Dysfunction trials with a reported enrollment target. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07405515, a NA study of Autonomic Dysfunction and Dysautonomia, is active but no longer recruiting, sponsored by Brigham and Women's Hospital.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
This study aims to better understand the biological mechanisms underlying dysautonomia and postural orthostatic tachycardia syndrome (POTS), including how these conditions may be related to COVID-19. Participants will attend a single research visit lasting approximately one hour, during which a blood sample will be collected for immune system and genetic analyses. Information from participants' medical records may also be reviewed to support the research. The knowledge gained from this study may help improve understanding, diagnosis, and treatment of dysautonomia in the future.
Primary Outcome
Peripheral blood will be collected from participants with POTS/dysautonomia, Long COVID, and healthy controls during a single research visit (\~1 hour). Samples will be analyzed to quantify cytokines, immune cell subsets, and inflammatory mediators to identify immune signatures associated with dysautonomia and PASC. Data will be aggregated by participant group and analyzed for differences in immune profiles.
Conditions Studied
Interventions
- OTHER Blood Sample Collection
Study Locations (1)
Massachusetts
- Brigham and Women's Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2024-02-02 |
| Est. Completion | 2027-12-31 |
| Phase | NA |
What the registry record for NCT07405515 still lists
NCT07405515 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, roughly in line with the 109-participant average among 8 other Autonomic Dysfunction trials with a reported enrollment target.
The record links to 4 conditions, with Autonomic Dysfunction appearing as the primary indexed condition, and to 1 intervention - of which Blood Sample Collection is the first listed.
NCT07405515 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT07405515 about?
NCT07405515 is a clinical study titled "Pathophysiology of Dysautonomia and Postural Tachycardia Syndrome (POTS) in Post-viral Syndromes and COVID-19". This study aims to better understand the biological mechanisms underlying dysautonomia and postural orthostatic tachycardia syndrome (POTS), including how these conditions may be related to COVID-19. Participants will attend a single research visit lasting approximately one hour, during which a bloo...
What is the current status of trial NCT07405515?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 100 participants. The study started on 2024-02-02. Estimated completion is 2027-12-31.
What conditions does trial NCT07405515 study?
This clinical trial studies the following conditions: Autonomic Dysfunction, Dysautonomia, POTS - Postural Orthostatic Tachycardia Syndrome, POTS.
What interventions are being tested in trial NCT07405515?
The interventions under investigation include: Blood Sample Collection (OTHER).
Who is sponsoring clinical trial NCT07405515?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07405515 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT07405515's enrollment target sits among peer trials
100 4th of 8 higher than 5 of 8 other Autonomic Dysfunction trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Autonomic Dysfunction trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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