Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 2

AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.

NCT06991114 · View on ClinicalTrials.gov ↗

Study Summary

A Basket Trial of Refractory Rheumatoid Arthritis (RA), Sjögren's Disease (SjD), Idiopathic Inflammatory Myopathies (IIMs) and Systemic Sclerosis (SSc) subjects to evaluate the safety and efficacy of AlloNK, a non-genetically modified allogeneic NK cell, in combination with rituximab.

Interventions

  • DRUG Allogeneic NK Cells

Study Locations (20)

Texas

  • Artiva Investigational Site Arlington — Arlington
  • Artiva Investigational Site Katy — Katy
  • Artiva Investigational Site Mesquite — Mesquite
  • Artiva Investigational Site Woodland — Woodland

Other

  • Artiva Investigational Site Sofia — Sofia
  • Artiva Investigational Site Marseille — Marseille
  • Artiva Investigational Site Montpellier — Montpellier
  • Artiva Investigational Site Toulouse — Toulouse

Florida

  • Artiva Investigational Site Aventura — Aventura
  • Artiva Investigational Site Jupiter — Jupiter
  • Artiva Investigational Site Plantation — Plantation

California

  • Artiva Investigational Site Covina — Covina
  • Artiva Investigational Site Los Alamitos — Los Alamitos

North Carolina

  • Artiva Investigational Site Charlotte — Charlotte
  • Artiva Investigational Site Charlotte — Charlotte

Alabama

  • Artiva Investigational Site Tuscaloosa — Tuscaloosa

Arizona

  • Artiva Investigational Site Phoenix — Phoenix

Illinois

  • Artiva Investigational Site Willowbrook — Willowbrook

Trial Details

FieldValue
Enrollment Target 90 participants
Start Date 2025-07-09
Est. Completion 2029-01
Phase Phase 2

Sponsor

Artiva Biotherapeutics

3 total trials

Interested in This Trial?

Always speak with your doctor before enrolling in a clinical trial.

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06991114

The ClinicalTrials.gov registry entry for NCT06991114 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 90 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Artiva Biotherapeutics, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 9 conditions, with Scleroderma appearing as the primary indexed condition, and to 1 intervention — of which Allogeneic NK Cells is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06991114 reports 20 study locations spanning 10 distinct geographic areas — top geographies include Texas, Other, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06991114 about?

NCT06991114 is a clinical study titled "AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.". A Basket Trial of Refractory Rheumatoid Arthritis (RA), Sjögren's Disease (SjD), Idiopathic Inflammatory Myopathies (IIMs) and Systemic Sclerosis (SSc) subjects to evaluate the safety and efficacy of AlloNK, a non-genetically modified allogeneic NK cell, in combination with rituximab.

What is the current status of trial NCT06991114?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 90 participants. The study started on 2025-07-09. Estimated completion is 2029-01.

What conditions does trial NCT06991114 study?

This clinical trial studies the following conditions: Scleroderma, Systemic Sclerosis (SSc), Myositis, Rheumatoid Arthritis (RA, Sjogren Syndrome. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06991114?

The interventions under investigation include: Allogeneic NK Cells (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06991114?

This trial is sponsored by Artiva Biotherapeutics, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06991114 being conducted?

This trial has 20 study locations across Alabama, Arizona, California, Florida, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial