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Scleroderma clinical trials
11 of 24 indexed Scleroderma trials are currently recruiting.
24 US clinical trials · 11 currently recruiting
Scleroderma is the subject of 24 registered US clinical trials on ClinicalTrials.gov, 11 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 9 in Phase 1-2 (earlier-stage). The most active sponsor is Johns Hopkins University, running 4 of these trials.
The research picture
Scleroderma has 24 registered US clinical trials, 11 of them open to new participants right now, about 46% of the total.
- 11
- recruiting participants now
- 46%
- of trials open to enrollment
- 3
- in Phase 3–4 (later-stage)
- 4
- top sponsor: Johns Hopkins University
Active & Recent Trials
24 total, page 1 of 1
Maternal Autoimmune Disease Research Alliance (MADRA) Registry
Duke University
NCT03276923
Rheumatology Diet Study
University of Central Florida
NCT06339957
Platform Clinical Study for Conquering Scleroderma
Scleroderma Research Foundation
NCT06195072
Scleroderma Registry & Repository at the Hospital for Special Surgery
Hospital for Special Surgery, New York
NCT01656447
A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune Disease
TScan Therapeutics
NCT06587828
AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.
Artiva Biotherapeutics
NCT06991114
Tibulizumab Systemic Sclerosis Understanding and Response Evaluation (TibuSURE)
Zura Bio
NCT06843239
Brain Boost Program to Improve Cognitive Function in People With Systemic Sclerosis
University of Michigan
NCT06880627
Sildenafil for Early Pulmonary Vascular Disease in Scleroderma
Johns Hopkins University
NCT04797286
TENS in Scleroderma
University of Michigan
NCT06646913
RESET-SSc: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201, a CD19-CAR T Cell Therapy, in Subjects With Systemic Sclerosis
Cabaletta Bio
NCT06328777
Determine Effectiveness of Anifrolumab In SYstemic Sclerosis (DAISY)
AstraZeneca
NCT05925803
MRI for Screening and Monitoring Scleroderma ILD
University of Kansas Medical Center
NCT05204355
Scleroderma Registry
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NCT00074568
The Scleroderma Biorepository and Pathogenesis Study (STOP Scleroderma)
George Washington University
NCT02887495
Novel Screening Strategies for Scleroderma PAH
University of Michigan
NCT01959815
Psychological Treatments for Scleroderma
Johns Hopkins University
NCT00007267
Phase III Study of a Topical Gel Formulation for Treatment and Prevention of Raynaud's Phenomenon
MediQuest Therapeutics
NCT00419419
Calcinosis in a Single-Center Scleroderma Population
Rutgers, The State University of New Jersey
NCT02062125
Efficacy of Botulinum Toxin In Scleroderma-Associated Raynaud's Syndrome
Johns Hopkins University
NCT02165111
A Study to Evaluate Safety and Tolerability of Multiple Doses of MEDI-546 in Adult Subjects With Scleroderma
MedImmune
NCT00930683
Transcutaneous Electroacupuncture for Gastric Complications of Scleroderma
Johns Hopkins University
NCT03294616
RENEW-AI: Personalizing Scleroderma Management With an AI Health Coach
University of Michigan
NCT06999226
The Effects of Botulinum Toxin on Oral Aperture in Patients With Scleroderma
University of Texas Southwestern Medical Center
NCT04523506
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 4 |
| Phase 2 | 5 |
| Phase 3 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Scleroderma Trial Landscape
24 indexed Scleroderma studies · 11 recruiting (46%).
Phase mix: 3 late (III/IV) vs 9 early (I/II).
Top sponsor: Johns Hopkins University (4 trials), 9 others listed. 24 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Scleroderma?
PlainTrial tracks 24 US clinical trials for Scleroderma, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Scleroderma?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.