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NCT04603898 · ClinicalTrials.gov registry record · NA
Oxalate Formation From Ascorbic Acid
A NA study of Kidney Stone, sponsored by University of Alabama at Birmingham.
- Recruiting
- Registry status
- NA
- Development phase
- 136
- Enrollment target
- 1
- Study location
NCT04603898: Recruiting NA study of Kidney Stone, sponsored by University of Alabama at Birmingham.
NCT04603898 is a NA study of Kidney Stone that is actively recruiting participants, run by University of Alabama at Birmingham. The registered enrollment target is 136 participants, below the 188-participant average among 28 other Kidney Stone trials with a reported enrollment target (28% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04603898, a NA study of Kidney Stone, is actively recruiting participants, sponsored by University of Alabama at Birmingham.
- RECRUITING
- Registry status
- NA
- Development phase
- 136 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this basic research study is to determine the contribution of endogenous ascorbic acid (AA) turnover to urinary oxalate excretion in both normal BMI and obese adult non-stone formers and calcium oxalate stone formers. The studies proposed will use diets of known nutrient composition, a stable isotope of ascorbic acid (13C6-AA) and mass spectrometric techniques to quantify ascorbic acid turnover to oxalate.
Primary Outcome
On the last day (Day 4) of controlled diet and 24 hours following ingestion of an oral load of carbon-13 AA (1mg/kg), urine and blood will be collected and the levels of carbon 12 and carbon 13 AA and oxalate measured to determine the percent contribution of AA metabolism to urinary oxalate excretion for each subject.
Conditions Studied
Interventions
- DIETARY_SUPPLEMENT Low Oxalate Diet
- DIETARY_SUPPLEMENT Carbon-13 Ascorbic Acid Oral Load
Study Locations (1)
Alabama
- University of Alabama at Birmingham - Birmingham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 136 participants |
| Start Date | 2021-11-15 |
| Est. Completion | 2026-12-01 |
| Phase | NA |
What NCT04603898 shows while recruiting
NCT04603898 is an interventional study that assigns participants to a tested intervention. The registered 136 participants enrollment target is mid-sized for trials with a published cap, below the 188-participant average among 28 other Kidney Stone trials with a reported enrollment target (28% lower).
The record links to 1 condition, with Kidney Stone appearing as the primary indexed condition, and to 2 interventions - of which Low Oxalate Diet is the first listed.
NCT04603898 reports a single indexed study location in Alabama.
Frequently Asked Questions
What is clinical trial NCT04603898 about?
NCT04603898 is a clinical study titled "Oxalate Formation From Ascorbic Acid". The purpose of this basic research study is to determine the contribution of endogenous ascorbic acid (AA) turnover to urinary oxalate excretion in both normal BMI and obese adult non-stone formers and calcium oxalate stone formers. The studies proposed will use diets of known nutrient composition, ...
What is the current status of trial NCT04603898?
This trial is currently recruiting. It is a NA study. The enrollment target is 136 participants. The study started on 2021-11-15. Estimated completion is 2026-12-01.
What conditions does trial NCT04603898 study?
This clinical trial studies the following conditions: Kidney Stone.
What interventions are being tested in trial NCT04603898?
The interventions under investigation include: Low Oxalate Diet (DIETARY_SUPPLEMENT), Carbon-13 Ascorbic Acid Oral Load (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT04603898?
This trial is sponsored by University of Alabama at Birmingham, which has 1,160 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04603898 being conducted?
This trial has 1 study location across Alabama. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Kidney Stone
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04603898's enrollment target sits among peer trials
136 7th of 28 higher than 22 of 28 other Kidney Stone trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Kidney Stone trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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