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NCT06718491 · ClinicalTrials.gov registry record · Phase 2
Brief Digitally-Enhanced Intervention for Reducing Alcohol Use During MOUD
A Phase 2 study of Opioid Use Disorder, sponsored by Ohio State University.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 80
- Enrollment target
- 1
- Study location
NCT06718491: Recruiting Phase 2 study of Opioid Use Disorder, sponsored by Ohio State University.
NCT06718491 is a Phase 2 study of Opioid Use Disorder that is actively recruiting participants, run by Ohio State University. The registered enrollment target is 80 participants, below the 4,656-participant average among 257 other Opioid Use Disorder trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06718491, a Phase 2 study of Opioid Use Disorder, is actively recruiting participants, sponsored by Ohio State University.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 80 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to reduce heavy drinking and enhance medication for opioid use disorder (MOUD) outcomes in individuals receiving MOUD. The main questions it aims to answer are: * Does the brief, digitally-enhanced, virtual psychotherapeutic intervention, called Managing Physical Reactions to Overwhelming Emotions (IMPROVE), impact daily alcohol use and MOUD adherence? * Does the intervention change self-report and physiological responses to intolerance to uncertainty and anxiety sensitivity? Researchers will compare IMPROVE to a control intervention (health education treatment) to see if IMPROVE impacts daily alcohol use and MOUD adherence. Participants will: * Complete a baseline electroencephalography (EEG) and self-report questionnaires. * Complete three one-hour intervention sessions (IMPROVE or control) each one week a part. * Complete a post-intervention EEG and self-report questionnaires. * Complete five ecological momentary assessment (EMA) surveys a day for 21 days. * Complete self-report questionnaires one-month after their last intervention session.
Primary Outcome
Changes in proportion of heavy drinking days and drinks per drinking day following the intervention.
Conditions Studied
Interventions
- BEHAVIORAL Managing Physical Reactions to Overwhelming Emotions (IMPROVE)
- BEHAVIORAL Health Education Training (HET)
Study Locations (1)
Ohio
- Ohio State University - Columbus
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2025-08-01 |
| Est. Completion | 2027-07 |
| Phase | Phase 2 |
What NCT06718491 shows while recruiting
NCT06718491 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 4,656-participant average among 257 other Opioid Use Disorder trials with a reported enrollment target (98% lower).
The record links to 1 condition, with Opioid Use Disorder appearing as the primary indexed condition, and to 2 interventions - of which Managing Physical Reactions to Overwhelming Emotions (IMPROVE) is the first listed.
NCT06718491 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT06718491 about?
NCT06718491 is a clinical study titled "Brief Digitally-Enhanced Intervention for Reducing Alcohol Use During MOUD". The goal of this clinical trial is to reduce heavy drinking and enhance medication for opioid use disorder (MOUD) outcomes in individuals receiving MOUD. The main questions it aims to answer are: * Does the brief, digitally-enhanced, virtual psychotherapeutic intervention, called Managing Physical ...
What is the current status of trial NCT06718491?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 80 participants. The study started on 2025-08-01. Estimated completion is 2027-07.
What conditions does trial NCT06718491 study?
This clinical trial studies the following conditions: Opioid Use Disorder.
What interventions are being tested in trial NCT06718491?
The interventions under investigation include: Managing Physical Reactions to Overwhelming Emotions (IMPROVE) (BEHAVIORAL), Health Education Training (HET) (BEHAVIORAL).
Who is sponsoring clinical trial NCT06718491?
This trial is sponsored by Ohio State University, which has 552 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06718491 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Opioid Use Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06718491's enrollment target sits among peer trials
80 143rd of 257 higher than 113 of 257 other Opioid Use Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Opioid Use Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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