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RECRUITING Phase 2

HSCT for Patients With Fanconi Anemia Using Risk-Adjusted Chemotherapy

NCT02143830 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to determine whether the use of lower doses of busulfan and the elimination of cyclosporine will further reduce transplant-related side effects for patients with Fanconi Anemia (FA). Patients will undergo a transplant utilizing mis-matched related or matched unrelated donors following a preparative regimen of busulfan, fludarabine, anti-thymocyte globulin and cyclophosphamide.

Interventions

  • DRUG Cyclophosphamide
  • DRUG Fludarabine
  • DRUG Busulfan
  • DRUG G-CSF
  • DRUG rabbit ATG

Study Locations (3)

New York

  • Memorial Sloan Kettering Cancer Center — New York

Ohio

  • Cincinnati Children's Hospital Medical Center — Cincinnati

Washington

  • Fred Hutchinson Cancer Research Center — Seattle

Trial Details

FieldValue
Enrollment Target 70 participants
Start Date 2014-04
Est. Completion 2028-12
Phase Phase 2

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02143830

The ClinicalTrials.gov registry entry for NCT02143830 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 70 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Children's Hospital Medical Center, Cincinnati, which has 715 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 4 conditions, with Myelodysplastic Syndrome (MDS) appearing as the primary indexed condition, and to 5 interventions — of which Cyclophosphamide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02143830 reports 3 study locations spanning 3 distinct geographic areas — top geographies include New York, Ohio, Washington. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02143830 about?

NCT02143830 is a clinical study titled "HSCT for Patients With Fanconi Anemia Using Risk-Adjusted Chemotherapy". The purpose of this study is to determine whether the use of lower doses of busulfan and the elimination of cyclosporine will further reduce transplant-related side effects for patients with Fanconi Anemia (FA). Patients will undergo a transplant utilizing mis-matched related or matched unrelated do...

What is the current status of trial NCT02143830?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 70 participants. The study started on 2014-04. Estimated completion is 2028-12.

What conditions does trial NCT02143830 study?

This clinical trial studies the following conditions: Myelodysplastic Syndrome (MDS), Fanconi Anemia, Acute Myelogenous Leukemia (AML), Severe Marrow Failure. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02143830?

The interventions under investigation include: Cyclophosphamide (DRUG), Fludarabine (DRUG), Busulfan (DRUG), G-CSF (DRUG), rabbit ATG (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02143830?

This trial is sponsored by Children's Hospital Medical Center, Cincinnati, which has 715 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02143830 being conducted?

This trial has 3 study locations across New York, Ohio, Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial