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NCT07224243 · ClinicalTrials.gov registry record · NA
Impact of Intraoperative Oxygenation Practices on Patient Outcomes
A NA study of Surgeries Undergoing General Anesthesia, sponsored by Frederic T Billings IV.
- Recruiting
- Registry status
- NA
- Development phase
- 54,000
- Enrollment target
- 1
- Study location
NCT07224243: Recruiting NA study of Surgeries Undergoing General Anesthesia, sponsored by Frederic T Billings IV.
NCT07224243 is a NA study of Surgeries Undergoing General Anesthesia that is actively recruiting participants, run by Frederic T Billings IV. The registered enrollment target is 54,000 participants, above the 1,403-participant average among 58,714 other NA trials with a reported enrollment target (3749% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07224243, a NA study of Surgeries Undergoing General Anesthesia, is actively recruiting participants, sponsored by Frederic T Billings IV.
- RECRUITING
- Registry status
- NA
- Development phase
- 54,000 participants
- Enrollment target
- 1
- Study location
Study Summary
This multicenter, cluster-randomized, cluster-crossover clinical trial evaluates the impact of three intraoperative FiO2 (Fraction of Inspired Oxygen) oxygenation strategies-lower (FiO₂ 0.21-0.40), intermediate (FiO₂ 0.40-0.80), and higher (FiO₂ 0.80-1.00)-on postoperative organ injury and mortality in adult surgical patients. The trial aims to determine the optimal oxygenation strategy to improve perioperative outcomes.
Primary Outcome
This composite outcome measures the number of participants experiencing at least one of the following organ injuries or death within the defined study period: * Acute Kidney Injury (AKI), defined according to creatinine based Kidney Disease Improving Global Outcomes criteria, specifically a 0.3 mg/dL or greater increase within 48 hours or a 50% or greater increase from baseline within seven days of surgery. * Myocardial injury, defined as \>99th percentile of normal based on site-specific tropo
Conditions Studied
Interventions
- OTHER Lower FiO2
- OTHER Intermediate FiO2
- OTHER Higher FiO2
Study Locations (1)
Tennessee
- Vanderbilt University Medical Center - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 54,000 participants |
| Start Date | 2025-12-01 |
| Est. Completion | 2028-04 |
| Phase | NA |
What NCT07224243 shows while recruiting
NCT07224243 is an interventional study that assigns participants to a tested intervention. Its 54,000 participants enrollment target places it among the larger protocols in the corpus, above the 1,403-participant average among 58,714 other NA trials with a reported enrollment target (3749% higher).
The record links to 1 condition, with Surgeries Undergoing General Anesthesia appearing as the primary indexed condition, and to 3 interventions - of which Lower FiO2 is the first listed.
NCT07224243 reports a single indexed study location in Tennessee.
Frequently Asked Questions
What is clinical trial NCT07224243 about?
NCT07224243 is a clinical study titled "Impact of Intraoperative Oxygenation Practices on Patient Outcomes". This multicenter, cluster-randomized, cluster-crossover clinical trial evaluates the impact of three intraoperative FiO2 (Fraction of Inspired Oxygen) oxygenation strategies-lower (FiO₂ 0.21-0.40), intermediate (FiO₂ 0.40-0.80), and higher (FiO₂ 0.80-1.00)-on postoperative organ injury and mortality...
What is the current status of trial NCT07224243?
This trial is currently recruiting. It is a NA study. The enrollment target is 54,000 participants. The study started on 2025-12-01. Estimated completion is 2028-04.
What conditions does trial NCT07224243 study?
This clinical trial studies the following conditions: Surgeries Undergoing General Anesthesia.
What interventions are being tested in trial NCT07224243?
The interventions under investigation include: Lower FiO2 (OTHER), Intermediate FiO2 (OTHER), Higher FiO2 (OTHER).
Who is sponsoring clinical trial NCT07224243?
This trial is sponsored by Frederic T Billings IV, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07224243 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07224243's enrollment target sits among peer trials
54,000 7th of 2000 higher than 1,994 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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