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ClinicalTrials.gov 8 recruiting now early-phase tilt small index

High-risk Neuroblastoma: early-phase trial registry

8 of 10 indexed High-risk Neuroblastoma trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #1,724 of 28,707 conditions by registered trial count.

10 US clinical trials · 8 currently recruiting · #1,724 of 28,707 conditions by registered trial count

High-risk Neuroblastoma: 10 US clinical trials tracked, 8 recruiting.

High-risk Neuroblastoma is the subject of 10 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most active sponsor is Stephan Grupp MD PhD, running 2 of these trials.

Enrollment posture brief

Registry condition high-risk-neuroblastoma

OPEN 8 | RECR 80% | LATE 0 | EARLY 8 | RANK #1724 | SPON 2

Nearest open-share peer: Ablation (80% recruiting · 5 trials)

Acute Leukemia of Ambiguous 80%High-risk Neuroblastoma (thi…80%Achondroplasia40%Accelerated Phase Chronic My20%Accidental Fall20%
Open-enrollment share among volume-matched conditions near High-risk Neuroblastoma

High-risk Neuroblastoma lists 8 open slots (80% of 10 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for High-risk Neuroblastoma on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. High-risk Neuroblastoma is recruiting above its size-band peers.

    8 of 10 indexed trials (80%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates High-risk Neuroblastoma research.

    Stephan Grupp MD PhD accounts for 2 of 10 trials (20%). 8 distinct sponsors appear on at least one study for this condition label.

  3. Most High-risk Neuroblastoma trials plan to enrol fewer than 100 people.

    Median target enrolment is 45 among the 10 trials that report a genuine target (sentinel values excluded). 10 of those (100%) plan for fewer than 100 participants.

  4. High-risk Neuroblastoma research is mostly interventional.

    9 interventional and 1 observational studies make up this index (90% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 14Phase 24

Open and recent trials

10 total, page 1 of 1

RECRUITING Phase 2 94 participants

A Study of a Vaccine in Combination With Beta-glucan in People With Neuroblastoma

Memorial Sloan Kettering Cancer Center

NCT06057948

RECRUITING NA 84 participants

Resource Intervention to Support Equity (RISE) in High-Risk Neuroblastoma

Dana-Farber Cancer Institute

NCT06831552

RECRUITING Phase 1 60 participants

GD2-SADA:177Lu-DOTA Complex in Patients With Solid Tumors Known to Express GD2

Y-mAbs Therapeutics

NCT05130255

RECRUITING 45 participants

Feasibility of Screening for Early Late Effects of Contemporary Therapy in High-Risk Neuroblastoma Survivors

St. Jude Children's Research Hospital

NCT06480526

RECRUITING Phase 1 45 participants

GPC2 CAR T Cells for Relapsed or Refractory Neuroblastoma and Metastatic Retinoblastoma

Stephan Grupp MD PhD

NCT05650749

RECRUITING Phase 2 45 participants

N10: A Study of Reduced Chemotherapy and Monoclonal Antibody (mAb)-Based Therapy in Children With Neuroblastoma

Memorial Sloan Kettering Cancer Center

NCT06528496

RECRUITING Phase 1 42 participants

Study of hALK.CAR T Cells for Patients With Relapsed/Refractory High-risk Neuroblastoma

Roberto Chiarle

NCT06803875

RECRUITING Phase 1 38 participants

PHOX2B PC-CAR T Cells for Relapsed Neuroblastoma

Stephan Grupp MD PhD

NCT07007117

ACTIVE NOT RECRUITING Phase 2 94 participants

Irinotecan Hydrochloride, Temozolomide, and Dinutuximab With or Without Eflornithine in Treating Patients With Relapsed or Refractory Neuroblastoma

Children's Oncology Group

NCT03794349

ACTIVE NOT RECRUITING Phase 2 42 participants

Dinutuximab, Sargramostim, and Combination Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma

National Cancer Institute (NCI)

NCT03786783

Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 4

Named interventions

Most-linked intervention names on High-risk Neuroblastoma records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Sargramostim Biological
2 trials
Eflornithine Hydrochloride Drug
1 trials
Dexrazoxane Drug
1 trials
Dinutuximab Biological
1 trials
Autologous hALK.CAR T cells Biological
1 trials
PHOX2B PC-CAR T Cells Biological
1 trials
oral β-glucan Dietary supplement
1 trials
OPT-821 (QS-21) Biological
1 trials

US sites by state

Facility locations filed on High-risk Neuroblastoma trials. A trial with sites in several states counts in each.

Pennsylvania 5 trials
New York 4 trials
Massachusetts 3 trials
California 3 trials
Tennessee 2 trials
Connecticut 2 trials
Wisconsin 1 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this High-risk Neuroblastoma page

10 registered trials, 8 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

  • 8 High-risk Neuroblastoma trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
  • Stephan Grupp MD PhD sponsors the most High-risk Neuroblastoma trials on record, review their full trial history before evaluating a specific study. See Stephan Grupp MD PhD's trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This High-risk Neuroblastoma condition card totals 10 registered trials; most-linked intervention Sargramostim; top US site state Pennsylvania. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.