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NCT05574296 · ClinicalTrials.gov registry record · Phase 1

Hydrogen's Feasibility and Safety as a Therapy in ECPR

A Phase 1 study of Cardiac Arrest and Extracorporeal Membrane Oxygenation, sponsored by Boston Children's Hospital.

Recruiting
Registry status
Phase 1
Development phase
53
Enrollment target
4
Study locations

NCT05574296 is a Phase 1 study of Cardiac Arrest and Extracorporeal Membrane Oxygenation that is actively recruiting participants, run by Boston Children's Hospital. The registered enrollment target is 53 participants, below the 1,478-participant average among 31 other Cardiac Arrest trials with a reported enrollment target (96% lower). The trial reports 4 study locations across 4 states.

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The verdict

NCT05574296, a Phase 1 study of Cardiac Arrest and Extracorporeal Membrane Oxygenation, is actively recruiting participants, sponsored by Boston Children's Hospital.

RECRUITING
Registry status
Phase 1
Development phase
53 participants
Enrollment target
4
Study locations

Study Summary

The purpose of this project is to test the feasibility and safety of inhaled hydrogen gas (H2) administration as a rescue therapy during cardiac arrest requiring extracorporeal cardiopulmonary resuscitation (ECPR, i.e. mechanical circulatory support). Under exemption from informed consent, patients undergoing refractory cardiac arrest in the cardiac ICU at a participating center will be randomized to standard therapy with or without the administration of 2% hydrogen in gases administered via the ventilator and ECMO membrane for 72 hours.

Conditions Studied

Cardiac Arrest Extracorporeal Membrane Oxygenation Reperfusion Injury

Interventions

  • OTHER Usual care
  • DRUG Hydrogen

Study Locations (4)

District of Columbia

  • Children's National Hospital - Washington D.C.

Massachusetts

  • Boston Children's Hospital - Boston

Missouri

  • Children's Mercy Kansas City - Kansas City

Utah

  • Primary Children's Hospital - Salt Lake City

Trial Details

FieldValue
Enrollment Target 53 participants
Start Date 2024-03-04
Est. Completion 2027-08-31
Phase Phase 1

Sponsor

Boston Children's Hospital

462 total trials

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What the Registry Record Tells You About NCT05574296

The ClinicalTrials.gov registry entry for NCT05574296 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 53 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 1,478-participant average among 31 other Cardiac Arrest trials with a reported enrollment target (96% lower). The listed sponsor is Boston Children's Hospital, which has 462 total studies on file at ClinicalTrials.gov.

The record links to 3 conditions, with Cardiac Arrest appearing as the primary indexed condition, and to 2 interventions - of which Usual care is the first listed.

NCT05574296 reports 4 study locations spanning 4 distinct geographic areas - top geographies include District of Columbia, Massachusetts, Missouri.

Frequently Asked Questions

What is clinical trial NCT05574296 about?

NCT05574296 is a clinical study titled "Hydrogen's Feasibility and Safety as a Therapy in ECPR". The purpose of this project is to test the feasibility and safety of inhaled hydrogen gas (H2) administration as a rescue therapy during cardiac arrest requiring extracorporeal cardiopulmonary resuscitation (ECPR, i.e. mechanical circulatory support). Under exemption from informed consent, patients ...

What is the current status of trial NCT05574296?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 53 participants. The study started on 2024-03-04. Estimated completion is 2027-08-31.

What conditions does trial NCT05574296 study?

This clinical trial studies the following conditions: Cardiac Arrest, Extracorporeal Membrane Oxygenation, Reperfusion Injury.

What interventions are being tested in trial NCT05574296?

The interventions under investigation include: Usual care (OTHER), Hydrogen (DRUG).

Who is sponsoring clinical trial NCT05574296?

This trial is sponsored by Boston Children's Hospital, which has 462 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05574296 being conducted?

This trial has 4 study locations across District of Columbia, Massachusetts, Missouri, Utah. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.