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NCT06155682 · ClinicalTrials.gov registry record · NA
TMS for Inhibition Enhancement in Schizophrenia
A NA study of Schizophrenia, sponsored by University of Maryland, Baltimore.
- Recruiting
- Registry status
- NA
- Development phase
- 34
- Enrollment target
- 1
- Study location
NCT06155682: Recruiting NA study of Schizophrenia, sponsored by University of Maryland, Baltimore.
NCT06155682 is a NA study of Schizophrenia that is actively recruiting participants, run by University of Maryland, Baltimore. The registered enrollment target is 34 participants, below the 219-participant average among 315 other Schizophrenia trials with a reported enrollment target (84% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06155682, a NA study of Schizophrenia, is actively recruiting participants, sponsored by University of Maryland, Baltimore.
- RECRUITING
- Registry status
- NA
- Development phase
- 34 participants
- Enrollment target
- 1
- Study location
Study Summary
This study purpose is to perform a pilot mechanistic trial repetitive transcranial magnetic stimulation (rTMS) clinical trial in 34 people with schizophrenia (Sz). The trial will evaluate whether inhibitory 1 Hertz (Hz) rTMS targeting motor cortex can increase brain inhibition reflected in a decrease in the short-interval intracortical inhibition (SICI) score from pre-to-post-treatment. We will also collect preliminary data on the effect of rTMS on the resting functional connectivity of the motor cortex and other brain regions and the relationship of change in SICI to change in cognitive performance
Primary Outcome
At baseline, and at the end of 5 days of rTMS treatment, we will perform 24 trials of paired-pulse TMS to calculate SICI score (defined as the ratio of the evoked motor potential to the paired-pulse TMS in our SICI protocol relative to a single suprathreshold pulse). We will average across these 24 trials to get an average SICI score (both pre-TMS and post-TMS). We will calculate the change in SICI score (pre-TMS to post-TMS) for each participant.
Conditions Studied
Interventions
- DEVICE repetitive transcranial magnetic stimulation (active)
- DEVICE repetitive transcranial magnetic stimulation (sham)
Study Locations (1)
Maryland
- Maryland Psychiatric Research Center - Catonsville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 34 participants |
| Start Date | 2026-02-02 |
| Est. Completion | 2029-04 |
| Phase | NA |
What NCT06155682 shows while recruiting
NCT06155682 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 34 participants, a relatively small participant target, below the 219-participant average among 315 other Schizophrenia trials with a reported enrollment target (84% lower).
The record links to 1 condition, with Schizophrenia appearing as the primary indexed condition, and to 2 interventions - of which repetitive transcranial magnetic stimulation (active) is the first listed.
NCT06155682 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT06155682 about?
NCT06155682 is a clinical study titled "TMS for Inhibition Enhancement in Schizophrenia". This study purpose is to perform a pilot mechanistic trial repetitive transcranial magnetic stimulation (rTMS) clinical trial in 34 people with schizophrenia (Sz). The trial will evaluate whether inhibitory 1 Hertz (Hz) rTMS targeting motor cortex can increase brain inhibition reflected in a decreas...
What is the current status of trial NCT06155682?
This trial is currently recruiting. It is a NA study. The enrollment target is 34 participants. The study started on 2026-02-02. Estimated completion is 2029-04.
What conditions does trial NCT06155682 study?
This clinical trial studies the following conditions: Schizophrenia.
What interventions are being tested in trial NCT06155682?
The interventions under investigation include: repetitive transcranial magnetic stimulation (active) (DEVICE), repetitive transcranial magnetic stimulation (sham) (DEVICE).
Who is sponsoring clinical trial NCT06155682?
This trial is sponsored by University of Maryland, Baltimore, which has 560 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06155682 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Schizophrenia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06155682's enrollment target sits among peer trials
34 255th of 315 higher than 61 of 315 other Schizophrenia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Schizophrenia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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