Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06453109 · ClinicalTrials.gov registry record · NA
Focused Ultrasound for the Complex Patient
A NA study of Anxiety and Opioid Use Disorder, sponsored by Washington D.C. Veterans Affairs Medical Center.
- Recruiting
- Registry status
- NA
- Development phase
- 25
- Enrollment target
- 1
- Study location
NCT06453109: Recruiting NA study of Anxiety and Opioid Use Disorder, sponsored by Washington D.C. Veterans Affairs Medical Center.
NCT06453109 is a NA study of Anxiety and Opioid Use Disorder that is actively recruiting participants, run by Washington D.C. Veterans Affairs Medical Center. The registered enrollment target is 25 participants, below the 440-participant average among 364 other Anxiety trials with a reported enrollment target (94% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06453109, a NA study of Anxiety and Opioid Use Disorder, is actively recruiting participants, sponsored by Washington D.C. Veterans Affairs Medical Center.
- RECRUITING
- Registry status
- NA
- Development phase
- 25 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to to inhibit the anterior insula (AI) with low intensity focused ultrasound (LIFU) to determine the causal role for the AI in pain processing, anxiety, and opiate cue-induced craving. The main question\[s\] it aims to answer are: * the safety and tolerability of LIFU delivered bilaterally to AI compared to sham stimulation in individuals with opiate use disorder (OUD), anxiety, and chronic back pain * the effects of LIFU vs sham on measures of pain processing, anxiety symptoms, and opiate cue-induced craving Participants will undergo anatomical MRI, neurological assessment, clinical assessment and patient query to assess the safety and tolerability of LIFU vs sham.
Primary Outcome
number of adverse events
Conditions Studied
Interventions
- DEVICE low intensity focused ultrasound (LIFU)
Study Locations (1)
District of Columbia
- Washington DC Veterans Affairs Medical Center - Washington D.C.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 25 participants |
| Start Date | 2024-04-29 |
| Est. Completion | 2025-09-30 |
| Phase | NA |
What NCT06453109 shows while recruiting
NCT06453109 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 25 participants, a relatively small participant target, below the 440-participant average among 364 other Anxiety trials with a reported enrollment target (94% lower).
The record links to 3 conditions, with Anxiety appearing as the primary indexed condition, and to 1 intervention - of which low intensity focused ultrasound (LIFU) is the first listed.
NCT06453109 reports a single indexed study location in District of Columbia.
Frequently Asked Questions
What is clinical trial NCT06453109 about?
NCT06453109 is a clinical study titled "Focused Ultrasound for the Complex Patient". The goal of this clinical trial is to to inhibit the anterior insula (AI) with low intensity focused ultrasound (LIFU) to determine the causal role for the AI in pain processing, anxiety, and opiate cue-induced craving. The main question\[s\] it aims to answer are: * the safety and tolerability of ...
What is the current status of trial NCT06453109?
This trial is currently recruiting. It is a NA study. The enrollment target is 25 participants. The study started on 2024-04-29. Estimated completion is 2025-09-30.
What conditions does trial NCT06453109 study?
This clinical trial studies the following conditions: Anxiety, Opioid Use Disorder, Chronic Back Pain.
What interventions are being tested in trial NCT06453109?
The interventions under investigation include: low intensity focused ultrasound (LIFU) (DEVICE).
Who is sponsoring clinical trial NCT06453109?
This trial is sponsored by Washington D.C. Veterans Affairs Medical Center, which has 8 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06453109 being conducted?
This trial has 1 study location across District of Columbia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Anxiety
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06453109's enrollment target sits among peer trials
25 317th of 364 higher than 47 of 364 other Anxiety trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Anxiety trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Digital Intervention for Physical Activity
RECRUITING · NA
-
Exploring Virtual Reality Adventure Training Exergaming
RECRUITING · NA
-
Brief Interventions for Coping with Distress
RECRUITING · NA
-
Personalized Feedback Intervention for Latinx Drinkers With Anxiety
RECRUITING · NA
-
Pilot Effectiveness Trial of an ACT Self-help Workbook Tailored Specifically for Prisons
RECRUITING · NA
-
REstoring Mental Health Through COmmUnity-based Psychological Services in New York City
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01166854 · 25 participants
Characterization of Familial Myopathy and Paget Disease of Bone
- NCT01913106 · 25 participants · Phase 1
HSV-tk + Valacyclovir Therapy in Combination With Brachytherapy for Recurrent Prostate Cancer
- NCT02138669 · 25 participants · NA
Intacs Prescription Inserts for Keratoconus Patients
- NCT02174549 · 25 participants · Phase 1
Dose-defining Study of Tirapazamine Combined With Embolization in Liver Cancer
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI