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NCT05283265 · ClinicalTrials.gov registry record · NA
Neurophysiological Mechanisms of Language Comprehension
A NA study of Language Disorders, sponsored by University of Alabama at Birmingham.
- Recruiting
- Registry status
- NA
- Development phase
- 153
- Enrollment target
- 1
- Study location
NCT05283265: Recruiting NA study of Language Disorders, sponsored by University of Alabama at Birmingham.
NCT05283265 is a NA study of Language Disorders that is actively recruiting participants, run by University of Alabama at Birmingham. The registered enrollment target is 153 participants, above the 64-participant average among 7 other Language Disorders trials with a reported enrollment target (139% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05283265, a NA study of Language Disorders, is actively recruiting participants, sponsored by University of Alabama at Birmingham.
- RECRUITING
- Registry status
- NA
- Development phase
- 153 participants
- Enrollment target
- 1
- Study location
Study Summary
First, in a recording-only self-paced reading experiment, patients with epilepsy undergoing intracranial monitoring for clinical purposes will read or listen to sentences presented to them one word at time while the investigators simultaneously record neural activity through intracranial electrodes that are implanted for clinical purposes (see subject populations). At the end of the sentence, the subjects have to indicate how they comprehended the sentence by selecting which of several pictures matches the sentence they just read. Behavioral measures that the investigators record and analyze are their response times to advance to each next word in the sentence, and which picture they chose for each sentence. These behavioral measures are compared against the neural activity simultaneously recorded as they are made. Then, in a later session, the same participants will participate in a task-related stimulation experiment. This follows the exact same design as the recording-only reading experiment, the only difference is that on some trials, at controlled moments during the sentence presentation intracranial electrical stimulation is delivered through adjacent intracranial electrode contacts. The investigators will examine the effect of this stimulation on the subjects comprehension of the sentences measured by their behavior, and on the simultaneously recorded neural activity.
Primary Outcome
The investigators will observe which picture the participant chooses at the end of each trial. The participant's choice will be measured by a touch screen that the patient touches to make their choice. The unit of measurement is the percentage of trials per condition studied in which participants choose the correct picture, versus the percentage of trials per condition studied in which participants choose the picture that reflects a patient-agent error (which reflects incorrect assignment of the
Conditions Studied
Interventions
- BEHAVIORAL Sentence Type
- OTHER Direct brain stimulation
Study Locations (1)
Alabama
- The University of Alabama at Birmingham Hospital - Birmingham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 153 participants |
| Start Date | 2022-04-08 |
| Est. Completion | 2026-10-08 |
| Phase | NA |
What NCT05283265 shows while recruiting
NCT05283265 is an interventional study that assigns participants to a tested intervention. The registered 153 participants enrollment target is mid-sized for trials with a published cap, above the 64-participant average among 7 other Language Disorders trials with a reported enrollment target (139% higher).
The record links to 1 condition, with Language Disorders appearing as the primary indexed condition, and to 2 interventions - of which Sentence Type is the first listed.
NCT05283265 reports a single indexed study location in Alabama.
Frequently Asked Questions
What is clinical trial NCT05283265 about?
NCT05283265 is a clinical study titled "Neurophysiological Mechanisms of Language Comprehension". First, in a recording-only self-paced reading experiment, patients with epilepsy undergoing intracranial monitoring for clinical purposes will read or listen to sentences presented to them one word at time while the investigators simultaneously record neural activity through intracranial electrodes ...
What is the current status of trial NCT05283265?
This trial is currently recruiting. It is a NA study. The enrollment target is 153 participants. The study started on 2022-04-08. Estimated completion is 2026-10-08.
What conditions does trial NCT05283265 study?
This clinical trial studies the following conditions: Language Disorders.
What interventions are being tested in trial NCT05283265?
The interventions under investigation include: Sentence Type (BEHAVIORAL), Direct brain stimulation (OTHER).
Who is sponsoring clinical trial NCT05283265?
This trial is sponsored by University of Alabama at Birmingham, which has 1,160 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05283265 being conducted?
This trial has 1 study location across Alabama. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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