Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

ACTIVE NOT RECRUITING Phase 2

Safety and Tolerability of Abelacimab (MAA868) vs. Rivaroxaban in Patients With Atrial Fibrillation

NCT04755283 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of the ANT-006 study is to evaluate the bleeding profile of abelacimab relative to rivaroxaban in patients with atrial fibrillation (AF) at moderate-to-high risk of stroke.

Interventions

  • BIOLOGICAL Abelacimab
  • DRUG Rivaroxaban

Study Locations (20)

Florida

  • Anthos Investigative Site — Clearwater
  • Anthos Investigative Site — Daytona Beach
  • Anthos Investigative Site — Largo
  • Anthos Investigative Site — Safety Harbor
  • Anthos Investigative Site — Saint Augustine

Alabama

  • Anthos Investigative Site — Huntsville
  • Anthos Investigative Site — Mobile

Maryland

  • Anthos Investigative Site — Baltimore
  • Anthos Investigative Site — Salisbury

Massachusetts

  • Anthos Investigative Site — Framingham
  • Anthos Investigative Site — Haverhill

New York

  • Anthos Investigative Site — Poughkeepsie
  • Anthos Investigative Site — Southampton

Connecticut

  • Anthos Investigative Site — Stamford

Georgia

  • Anthos Investigative Site — Johns Creek

Kentucky

  • Anthos Investigative Site — Owensboro

Trial Details

FieldValue
Enrollment Target 1,287 participants
Start Date 2021-02-02
Est. Completion 2028-12-29
Phase Phase 2

Sponsor

Anthos Therapeutics

3 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04755283

The ClinicalTrials.gov registry entry for NCT04755283 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,287 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Anthos Therapeutics, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Stroke appearing as the primary indexed condition, and to 2 interventions — of which Abelacimab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04755283 reports 20 study locations spanning 12 distinct geographic areas — top geographies include Florida, Alabama, Maryland. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04755283 about?

NCT04755283 is a clinical study titled "Safety and Tolerability of Abelacimab (MAA868) vs. Rivaroxaban in Patients With Atrial Fibrillation". The purpose of the ANT-006 study is to evaluate the bleeding profile of abelacimab relative to rivaroxaban in patients with atrial fibrillation (AF) at moderate-to-high risk of stroke.

What is the current status of trial NCT04755283?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 1,287 participants. The study started on 2021-02-02. Estimated completion is 2028-12-29.

What conditions does trial NCT04755283 study?

This clinical trial studies the following conditions: Stroke, Atrial Fibrillation (AF). These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04755283?

The interventions under investigation include: Abelacimab (BIOLOGICAL), Rivaroxaban (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04755283?

This trial is sponsored by Anthos Therapeutics, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04755283 being conducted?

This trial has 20 study locations across Alabama, Connecticut, Florida, Georgia, Kentucky. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial