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NCT06842745 · ClinicalTrials.gov registry record · Phase 2
Transcranial Magnetic Stimulation + Language Therapy to Treat Mild Aphasia
A Phase 2 study of Stroke and Aphasia, sponsored by University of Pennsylvania.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 24
- Enrollment target
- 1
- Study location
NCT06842745: Recruiting Phase 2 study of Stroke and Aphasia, sponsored by University of Pennsylvania.
NCT06842745 is a Phase 2 study of Stroke and Aphasia that is actively recruiting participants, run by University of Pennsylvania. The registered enrollment target is 24 participants, below the 12,016-participant average among 454 other Stroke trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06842745, a Phase 2 study of Stroke and Aphasia, is actively recruiting participants, sponsored by University of Pennsylvania.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 24 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with Speech-Language Therapy (SLT) is an effective treatment for mild aphasia in persons with chronic stroke. The main questions this study aims to answer are: 1. Can TMS combined with SLT improve conversational speech and comprehension? 2. Can we identify specific behavioral and biological characteristics that would benefit most from the TMS and SLT treatment? Researchers will compare real TMS to sham (fake) TMS to see whether TMS can treat post-stroke mild aphasia. Participants will: * Complete a screening and medical intake to determine eligibility * Undergo a MRI * Participate in 10 consecutive sessions (Monday-Friday) of TMS and SLT treatment * Complete follow-up assessments 2 and 4 months after treatment
Primary Outcome
Change in performance on the Temple Assessment of Language and Short-term Memory in Aphasia (TALSA) sentence processing composite score.
Conditions Studied
Interventions
- BEHAVIORAL Speech-Language Therapy (SLT)
- DEVICE Transcranial Magnetic Stimulation (TMS)
Study Locations (1)
Pennsylvania
- University of Pennsylvania - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2025-02-11 |
| Est. Completion | 2026-08-31 |
| Phase | Phase 2 |
What NCT06842745 shows while recruiting
NCT06842745 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 24 participants, a relatively small participant target, below the 12,016-participant average among 454 other Stroke trials with a reported enrollment target (100% lower).
The record links to 4 conditions, with Stroke appearing as the primary indexed condition, and to 2 interventions - of which Speech-Language Therapy (SLT) is the first listed.
NCT06842745 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT06842745 about?
NCT06842745 is a clinical study titled "Transcranial Magnetic Stimulation + Language Therapy to Treat Mild Aphasia". The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with Speech-Language Therapy (SLT) is an effective treatment for mild aphasia in persons with chronic stroke. The main questions this study aims to answer are: 1. Can TMS combined with SLT improve c...
What is the current status of trial NCT06842745?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 24 participants. The study started on 2025-02-11. Estimated completion is 2026-08-31.
What conditions does trial NCT06842745 study?
This clinical trial studies the following conditions: Stroke, Aphasia, Aphasia, Acquired, Aphasia Following Cerebral Infarction.
What interventions are being tested in trial NCT06842745?
The interventions under investigation include: Speech-Language Therapy (SLT) (BEHAVIORAL), Transcranial Magnetic Stimulation (TMS) (DEVICE).
Who is sponsoring clinical trial NCT06842745?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06842745 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Stroke
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06842745's enrollment target sits among peer trials
24 336th of 454 higher than 109 of 454 other Stroke trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Stroke trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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