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COMPLETED Phase 1

A First-in-Human Study of RPT193 in Healthy Volunteers and Patients With Atopic Dermatitis

NCT04271514 · View on ClinicalTrials.gov ↗

Study Summary

This study is a first-in-human, 3-part, multi-center, Phase 1, randomized, double-blind, placebo-controlled study with RPT193 in up to 64 healthy male and female subjects and 30 male and female patients with atopic dermatitis. RPT193 is an orally-available, potent, and selective antagonist of CCR4.

Conditions Studied

Interventions

  • DRUG Placebo
  • DRUG RPT193

Study Locations (14)

Florida

  • Lenus Research & Medical Group — Miami
  • ForCare Clinical Research — Tampa

Louisiana

  • DelRicht Research — Baton Rouge
  • Clinical Trials Management,LLC — Metairie

Texas

  • DermResearch, Inc. — Austin
  • Progressive Clinical Research PA — San Antonio

Alabama

  • Pinnacle Research Group, LLC — Anniston

Arizona

  • Perseverance Research Center LLC — Scottsdale

California

  • University Clinical Trials, Inc — San Diego

Indiana

  • Dawes Fretzin Clinical Research Group, LLC — Indianapolis

Massachusetts

  • MetroBoston Clinical Partners LLC — Brighton

Trial Details

FieldValue
Enrollment Target 103 participants
Start Date 2019-08-12
Est. Completion 2021-04-26
Phase Phase 1

Sponsor

RAPT Therapeutics

3 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04271514

The ClinicalTrials.gov registry entry for NCT04271514 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 103 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is RAPT Therapeutics, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Atopic Dermatitis appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04271514 reports 14 study locations spanning 11 distinct geographic areas — top geographies include Florida, Louisiana, Texas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04271514 about?

NCT04271514 is a clinical study titled "A First-in-Human Study of RPT193 in Healthy Volunteers and Patients With Atopic Dermatitis". This study is a first-in-human, 3-part, multi-center, Phase 1, randomized, double-blind, placebo-controlled study with RPT193 in up to 64 healthy male and female subjects and 30 male and female patients with atopic dermatitis. RPT193 is an orally-available, potent, and selective antagonist of CCR4.

What is the current status of trial NCT04271514?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 103 participants. The study started on 2019-08-12. Estimated completion is 2021-04-26.

What conditions does trial NCT04271514 study?

This clinical trial studies the following conditions: Atopic Dermatitis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04271514?

The interventions under investigation include: Placebo (DRUG), RPT193 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04271514?

This trial is sponsored by RAPT Therapeutics, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04271514 being conducted?

This trial has 14 study locations across Alabama, Arizona, California, Florida, Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial