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NCT04690348 · ClinicalTrials.gov registry record · Phase 2
Intracavitary Carrier-embedded Cs131 Brachytherapy for Recurrent Brain Metastases: a Randomized Phase II Study
A Phase 2 study of Recurrent Brain Metastases, sponsored by Memorial Sloan Kettering Cancer Center.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 103
- Enrollment target
- 6
- Study locations
NCT04690348: Recruiting Phase 2 study of Recurrent Brain Metastases, sponsored by Memorial Sloan Kettering Cancer Center.
NCT04690348 is a Phase 2 study of Recurrent Brain Metastases that is actively recruiting participants, run by Memorial Sloan Kettering Cancer Center. The registered enrollment target is 103 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (23% lower). The trial reports 6 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04690348, a Phase 2 study of Recurrent Brain Metastases, is actively recruiting participants, sponsored by Memorial Sloan Kettering Cancer Center.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 103 participants
- Enrollment target
- 6
- Study locations
Study Summary
The purpose of this study is to see if Cs-131 brachytherapy is effective in people with recurrent brain cancer who are scheduled to have brain surgery for removal of their tumor(s). The researchers would like to see whether Cs-131 prevents brain tumors from growing back after surgery.The researchers will compare Cs-131 brachytherapy (which occurs during brain surgery) with the usual approach of brain surgery without brachytherapy. The researchers will compare both the effectiveness and safety of the two approaches.
Primary Outcome
With a contrast enhanced brain MRI scan. Treatment response will be determined based on the Response Assessment in Neuro-Oncology Brain Metastases (RANO-BM) criteria.
Conditions Studied
Interventions
- PROCEDURE Craniotomy
- RADIATION Cesium-131 brachytherapy
Study Locations (6)
New York
- Memorial Sloan Kettering Commack (Consent Only) - Commack
- Memorial Sloan Kettering Cancer Center - New York
- Memorial Sloan Kettering Nassau (Limited Protocol Activities) - Uniondale
New Jersey
- Memorial Sloan Kettering at Basking Ridge (Consent Only) - Basking Ridge
- Memorial Sloan Kettering Monmouth (Consent Only) - Middletown
Florida
- Baptist Health South Florida - Miami
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 103 participants |
| Start Date | 2020-12-24 |
| Est. Completion | 2026-12 |
| Phase | Phase 2 |
What NCT04690348 shows while recruiting
NCT04690348 is an interventional study that assigns participants to a tested intervention. The registered 103 participants enrollment target is mid-sized for trials with a published cap, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (23% lower).
The record links to 1 condition, with Recurrent Brain Metastases appearing as the primary indexed condition, and to 2 interventions - of which Craniotomy is the first listed.
NCT04690348 lists 6 locations in 3 states (New York, New Jersey, Florida).
Frequently Asked Questions
What is clinical trial NCT04690348 about?
NCT04690348 is a clinical study titled "Intracavitary Carrier-embedded Cs131 Brachytherapy for Recurrent Brain Metastases: a Randomized Phase II Study". The purpose of this study is to see if Cs-131 brachytherapy is effective in people with recurrent brain cancer who are scheduled to have brain surgery for removal of their tumor(s). The researchers would like to see whether Cs-131 prevents brain tumors from growing back after surgery.The researchers...
What is the current status of trial NCT04690348?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 103 participants. The study started on 2020-12-24. Estimated completion is 2026-12.
What conditions does trial NCT04690348 study?
This clinical trial studies the following conditions: Recurrent Brain Metastases.
What interventions are being tested in trial NCT04690348?
The interventions under investigation include: Craniotomy (PROCEDURE), Cesium-131 brachytherapy (RADIATION).
Who is sponsoring clinical trial NCT04690348?
This trial is sponsored by Memorial Sloan Kettering Cancer Center, which has 1,884 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04690348 being conducted?
This trial has 6 study locations across Florida, New Jersey, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04690348's enrollment target sits among peer trials
103 664th of 2000 higher than 1,334 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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