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NCT04107077 · ClinicalTrials.gov registry record · Phase 2
Phase II Study of the Effects of Laparoscopic Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Patients With Advanced Gastric Cancer
A Phase 2 study of Gastric Cancer and Peritoneal Carcinomatosis, sponsored by University of Chicago.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 21
- Enrollment target
- 1
- Study location
NCT04107077: Recruiting Phase 2 study of Gastric Cancer and Peritoneal Carcinomatosis, sponsored by University of Chicago.
NCT04107077 is a Phase 2 study of Gastric Cancer and Peritoneal Carcinomatosis that is actively recruiting participants, run by University of Chicago. The registered enrollment target is 21 participants, below the 319-participant average among 153 other Gastric Cancer trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04107077, a Phase 2 study of Gastric Cancer and Peritoneal Carcinomatosis, is actively recruiting participants, sponsored by University of Chicago.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 21 participants
- Enrollment target
- 1
- Study location
Study Summary
To assess if PD-L1 expression can be upregulated in peritoneal metastases from gastric cancer after the administration of HIPEC with greater frequency compared to systemic chemotherapy alone
Primary Outcome
To examine if PD-L1 expression can be upregulated in peritoneal metastases from gastric cancer after the administration of HIPEC with greater frequency compared to systemic chemotherapy alone. PD-L1 expression will be measured quantitatively by combined positive score (CPS), with upregulation defined as an quantitative increase in PD-L1 expression via CPS compared to the previously measured timepoint (baseline CPS of 0).
Conditions Studied
Interventions
- DRUG Cisplatin
- DRUG Mitomycin
Study Locations (1)
Illinois
- University of Chicago - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 21 participants |
| Start Date | 2025-09-09 |
| Est. Completion | 2026-06-01 |
| Phase | Phase 2 |
What NCT04107077 shows while recruiting
NCT04107077 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 21 participants, a relatively small participant target, below the 319-participant average among 153 other Gastric Cancer trials with a reported enrollment target (93% lower).
The record links to 2 conditions, with Gastric Cancer appearing as the primary indexed condition, and to 2 interventions - of which Cisplatin is the first listed.
NCT04107077 reports a single indexed study location in Illinois.
Frequently Asked Questions
What is clinical trial NCT04107077 about?
NCT04107077 is a clinical study titled "Phase II Study of the Effects of Laparoscopic Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Patients With Advanced Gastric Cancer". To assess if PD-L1 expression can be upregulated in peritoneal metastases from gastric cancer after the administration of HIPEC with greater frequency compared to systemic chemotherapy alone
What is the current status of trial NCT04107077?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 21 participants. The study started on 2025-09-09. Estimated completion is 2026-06-01.
What conditions does trial NCT04107077 study?
This clinical trial studies the following conditions: Gastric Cancer, Peritoneal Carcinomatosis.
What interventions are being tested in trial NCT04107077?
The interventions under investigation include: Cisplatin (DRUG), Mitomycin (DRUG).
Who is sponsoring clinical trial NCT04107077?
This trial is sponsored by University of Chicago, which has 796 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04107077 being conducted?
This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Gastric Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04107077's enrollment target sits among peer trials
21 147th of 153 higher than 7 of 153 other Gastric Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Gastric Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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