Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Chronic Fatigue Syndrome: early-phase trial registry
6 of 16 indexed Chronic Fatigue Syndrome trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #1,060 of 28,707 conditions by registered trial count.
16 US clinical trials · 6 currently recruiting · #1,060 of 28,707 conditions by registered trial count
Chronic Fatigue Syndrome: 16 US clinical trials tracked, 6 recruiting.
Chronic Fatigue Syndrome is the subject of 16 registered US clinical trials on ClinicalTrials.gov, 6 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Icahn School of Medicine at Mount Sinai, running 3 of these trials.
Enrollment posture brief
Registry condition chronic-fatigue-syndrome
OPEN 6 | RECR 38% | LATE 0 | EARLY 5 | RANK #1060 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Acute-graft-versus-host Disease (38% recruiting · 8 trials)
Chronic Fatigue Syndrome lists 6 open slots (38% of 16 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Chronic Fatigue Syndrome on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Chronic Fatigue Syndrome is recruiting below its size-band peers.
6 of 16 indexed trials (37.5%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Chronic Fatigue Syndrome research.
Icahn School of Medicine at Mount Sinai accounts for 3 of 16 trials (18.8%). 13 distinct sponsors appear on at least one study for this condition label.
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Most Chronic Fatigue Syndrome trials plan to enrol fewer than 100 people.
Median target enrolment is 50 among the 15 trials that report a genuine target (sentinel values excluded). 9 of those (60%) plan for fewer than 100 participants.
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Chronic Fatigue Syndrome research is mostly interventional.
14 interventional and 2 observational studies make up this index (87.5% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
16 total, page 1 of 1
The Long COVID-19 Wearable Device Study
Scripps Translational Science Institute
NCT05741112
Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.
University of Alabama at Birmingham
NCT03759522
Lumbrokinase for Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Icahn School of Medicine at Mount Sinai
NCT06511050
Assessment of N-Acetylcysteine as Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Weill Medical College of Cornell University
NCT04542161
Hydrogen Water Intervention With Heart Rate Variability as an Outcome Biomarker in ME/CFS
Stony Brook University
NCT07009691
tVNS in Long COVID-19
Icahn School of Medicine at Mount Sinai
NCT06585254
Does a Technology Enabled Multi-disciplinary Team-based Care Model for the Management of Long COVID and Other Fatiguing Illnesses Improve Clinical Care of Patients and Represent a Sustainable Approach Within a Federally Qualified Health Center?
Family Health Centers of San Diego
NCT05167227
Central Mechanisms of Chronic Pain and Fatigue Subtitle: Functional Imaging of Brain and Spinal Cord
University of Florida
NCT03075254
Cardiovascular Analysis of PEM
Icahn School of Medicine at Mount Sinai
NCT04740736
Treatment of Fibromyalgia With Recovery Factors
Practitioners Alliance Network
NCT04381780
The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome
Brigham and Women's Hospital
NCT03674541
Behavioral Insomnia Therapy With Chronic Fatigue Syndrome
Duke University
NCT00540254
Traditional African Healing Ceremony in a U.S. Population
Duke University
NCT01873482
Epstein-Barr Virus as a Possible Cause for Chronic Fatigue Syndrome
University of Mississippi Medical Center
NCT00433355
Acupressure for Pain Management and Fatigue Relief in Gulf War Veterans
The Cleveland Clinic
NCT02075489
Hyporeactivity and Gulf War Illness
US Department of Veterans Affairs
NCT00100412
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Chronic Fatigue Syndrome records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Chronic Fatigue Syndrome trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Chronic Fatigue Syndrome page
16 registered trials, 6 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 6 Chronic Fatigue Syndrome trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Icahn School of Medicine at Mount Sinai sponsors the most Chronic Fatigue Syndrome trials on record, review their full trial history before evaluating a specific study. See Icahn School of Medicine at Mount Sinai's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Chronic Fatigue Syndrome condition card totals 16 registered trials; most-linked intervention Usual Care for Chronic Fatigue Syndrome (Active Control Group); top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.