Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT03263936 · ClinicalTrials.gov registry record · Phase 1
Epigenetic Reprogramming in Relapse/Refractory AML
A Phase 1 study of Acute Myelogenous Leukemia, sponsored by Therapeutic Advances in Childhood Leukemia Consortium.
- Completed
- Registry status
- Phase 1
- Development phase
- 37
- Enrollment target
- 20
- Study locations
NCT03263936 is a Phase 1 study of Acute Myelogenous Leukemia that has completed, run by Therapeutic Advances in Childhood Leukemia Consortium. The registered enrollment target is 37 participants, below the 139-participant average among 38 other Acute Myelogenous Leukemia trials with a reported enrollment target (73% lower). The trial reports 20 study locations across 13 states.
The verdict
NCT03263936, a Phase 1 study of Acute Myelogenous Leukemia, has completed, sponsored by Therapeutic Advances in Childhood Leukemia Consortium.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 37 participants
- Enrollment target
- 20
- Study locations
Study Summary
This is a pilot study using decitabine and vorinostat before and during chemotherapy with fludarabine, cytarabine and G-CSF (FLAG).
Conditions Studied
Interventions
- DRUG Fludarabine
- DRUG Decitabine
- DRUG Cytarabine
- DRUG Vorinostat
- DRUG Filgrastim (G-CSF)
Study Locations (20)
California
- Children's Hospital Los Angeles - Los Angeles
- Children's Hospital Orange County - Orange
- UCSF School of Medicine - San Francisco
Maryland
- Johns Hopkins University - Baltimore
- Sidney Kimmel Cancer Center at Johns Hopkins - Baltimore
- National Cancer Institute, Pediatric Oncology Branch - Bethesda
Florida
- University of Miami - Miami
- All Children's Hospital - St. Petersburg
Michigan
- C.S. Mott Children's Hospital - Ann Arbor
- CS Mott Children's Hospital, Ann Arbor - Ann Arbor
New York
- New York University Medical Center - New York
- Children's Hospital New York-Presbyterian - New York
Colorado
- The Children's Hospital, University of Colorado - Aurora
District of Columbia
- Children's National Medical Center - Washington D.C.
Georgia
- Children's Healthcare of Atlanta, Emory University - Atlanta
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 37 participants |
| Start Date | 2017-07-11 |
| Est. Completion | 2022-02-10 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03263936
The ClinicalTrials.gov registry entry for NCT03263936 describes a study currently listed as completed, categorized as Phase 1. The registered enrollment target is 37 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 139-participant average among 38 other Acute Myelogenous Leukemia trials with a reported enrollment target (73% lower). The listed sponsor is Therapeutic Advances in Childhood Leukemia Consortium, which has 19 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Acute Myelogenous Leukemia appearing as the primary indexed condition, and to 5 interventions - of which Fludarabine is the first listed.
NCT03263936 reports 20 study locations spanning 13 distinct geographic areas - top geographies include California, Maryland, Florida.
Frequently Asked Questions
What is clinical trial NCT03263936 about?
NCT03263936 is a clinical study titled "Epigenetic Reprogramming in Relapse/Refractory AML". This is a pilot study using decitabine and vorinostat before and during chemotherapy with fludarabine, cytarabine and G-CSF (FLAG).
What is the current status of trial NCT03263936?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 37 participants. The study started on 2017-07-11. Estimated completion is 2022-02-10.
What conditions does trial NCT03263936 study?
This clinical trial studies the following conditions: Acute Myelogenous Leukemia.
What interventions are being tested in trial NCT03263936?
The interventions under investigation include: Fludarabine (DRUG), Decitabine (DRUG), Cytarabine (DRUG), Vorinostat (DRUG), Filgrastim (G-CSF) (DRUG).
Who is sponsoring clinical trial NCT03263936?
This trial is sponsored by Therapeutic Advances in Childhood Leukemia Consortium, which has 19 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03263936 being conducted?
This trial has 20 study locations across California, Colorado, District of Columbia, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Acute Myelogenous Leukemia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
ICP-248 in Combination With Azacitidine for the Treatment in Patients With Myeloid Malignancies
RECRUITING · Phase 1
-
Dendritic Cell/AML Fusion Cell Vaccine Following Allogeneic Transplantation in AML Patients
ACTIVE NOT RECRUITING · Phase 1
-
Study of Anti-CD33 Chimeric Antigen Receptor-Expressing T Cells (CD33CART) in Children and Young Adults With Relapsed/Refractory Acute Myeloid Leukemia
ACTIVE NOT RECRUITING · Phase 1
-
Safety Study of Gene Modified Donor T-cells Following Partially Mismatched Stem Cell Transplant
ACTIVE NOT RECRUITING · Phase 1
-
First in Human Study to Determine the Safety, Tolerability and Preliminary Efficacy of an Anti-CXCR4 Antibody in Subjects With Acute Myelogenous Leukemia and Selected B-cell Cancers
COMPLETED · Phase 1
-
Study of Itacitinib for the Prophylaxis of Graft-Versus-Host Disease and Cytokine Release Syndrome After T-cell Replete Haploidentical Peripheral Blood Hematopoietic Cell Transplantation
COMPLETED · Phase 1
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.