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NCT02399371 · ClinicalTrials.gov registry record · Phase 2
Pembrolizumab in Treating Patients With Malignant Mesothelioma
A Phase 2 study of Pleural Malignant Mesothelioma and Epithelioid Mesothelioma, sponsored by University of Chicago.
- Active
- Registry status
- Phase 2
- Development phase
- 65
- Enrollment target
- 1
- Study location
NCT02399371: Active Phase 2 study of Pleural Malignant Mesothelioma and Epithelioid Mesothelioma, sponsored by University of Chicago.
NCT02399371 is a Phase 2 study of Pleural Malignant Mesothelioma and Epithelioid Mesothelioma that is active but no longer recruiting, run by University of Chicago. The registered enrollment target is 65 participants, above the 51-participant average among 4 other Pleural Malignant Mesothelioma trials with a reported enrollment target (27% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02399371, a Phase 2 study of Pleural Malignant Mesothelioma and Epithelioid Mesothelioma, is active but no longer recruiting, sponsored by University of Chicago.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 65 participants
- Enrollment target
- 1
- Study location
Study Summary
This phase II trial studies how well pembrolizumab works in treating patients with malignant mesothelioma, a cancer of the linings around the lungs (pleura) or abdomen (peritoneum). Monoclonal antibodies, such as pembrolizumab, work by blocking a protein called programmed cell death 1 (PD-1) which may stimulate an immune response and kill tumor cells.
Primary Outcome
The Youden Index will be used to determine the optimal threshold for PD-L1 expression in correlation with tumor response. Youden Index ranges from 0-1 with higher scores meaning greater accuracy/sensitivity/specificity calculated from an ROC AUC (sensitivity + specificity - 1 = Youden Index).
Conditions Studied
Interventions
- BIOLOGICAL Pembrolizumab
- OTHER Laboratory Biomarker Analysis
- OTHER Pharmacogenomic Study
Study Locations (1)
Illinois
- University of Chicago - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 65 participants |
| Start Date | 2015-03-31 |
| Est. Completion | 2026-03-20 |
| Phase | Phase 2 |
What the registry record for NCT02399371 still lists
NCT02399371 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 65 participants, a relatively small participant target, above the 51-participant average among 4 other Pleural Malignant Mesothelioma trials with a reported enrollment target (27% higher).
The record links to 10 conditions, with Pleural Malignant Mesothelioma appearing as the primary indexed condition, and to 3 interventions - of which Pembrolizumab is the first listed.
NCT02399371 reports a single indexed study location in Illinois.
Frequently Asked Questions
What is clinical trial NCT02399371 about?
NCT02399371 is a clinical study titled "Pembrolizumab in Treating Patients With Malignant Mesothelioma". This phase II trial studies how well pembrolizumab works in treating patients with malignant mesothelioma, a cancer of the linings around the lungs (pleura) or abdomen (peritoneum). Monoclonal antibodies, such as pembrolizumab, work by blocking a protein called programmed cell death 1 (PD-1) which m...
What is the current status of trial NCT02399371?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 65 participants. The study started on 2015-03-31. Estimated completion is 2026-03-20.
What conditions does trial NCT02399371 study?
This clinical trial studies the following conditions: Pleural Malignant Mesothelioma, Epithelioid Mesothelioma, Recurrent Peritoneal Malignant Mesothelioma, Peritoneal Malignant Mesothelioma, Pleural Biphasic Mesothelioma.
What interventions are being tested in trial NCT02399371?
The interventions under investigation include: Pembrolizumab (BIOLOGICAL), Laboratory Biomarker Analysis (OTHER), Pharmacogenomic Study (OTHER).
Who is sponsoring clinical trial NCT02399371?
This trial is sponsored by University of Chicago, which has 796 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02399371 being conducted?
This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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