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ACTIVE NOT RECRUITING Phase 1

Pemetrexed Disodium and Cisplatin With or Without Cediranib Maleate in Treating Patients With Malignant Pleural Mesothelioma

NCT01064648 · View on ClinicalTrials.gov ↗

Study Summary

This randomized phase I/II trial is studying the side effects and best dose of cediranib maleate when given together with pemetrexed disodium and cisplatin and to see how well it works in treating patients with malignant pleural mesothelioma. Drugs used in chemotherapy, pemetrexed disodium and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Cediranib maleate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Giving pemetrexed disodium and cisplatin together with cediranib maleate may kill more tumor cells.

Interventions

  • DRUG Cisplatin
  • OTHER Laboratory Biomarker Analysis
  • OTHER Placebo Administration
  • DRUG Cediranib Maleate
  • DRUG Pemetrexed Disodium

Study Locations (20)

California

  • Kaiser Permanente-Deer Valley Medical Center — Antioch
  • Providence Saint Joseph Medical Center/Disney Family Cancer Center — Burbank
  • Kaiser Permanente-Fremont — Fremont
  • Kaiser Permanente-Fresno — Fresno
  • Los Angeles General Medical Center — Los Angeles
  • USC / Norris Comprehensive Cancer Center — Los Angeles
  • Kaiser Permanente-Modesto — Modesto
  • Kaiser Permanente-Oakland — Oakland
  • UC Irvine Health/Chao Family Comprehensive Cancer Center — Orange
  • Kaiser Permanente-Redwood City — Redwood City
  • Kaiser Permanente-Richmond — Richmond
  • Kaiser Permanente-Roseville — Roseville
  • University of California Davis Comprehensive Cancer Center — Sacramento
  • Kaiser Permanente-South Sacramento — Sacramento
  • Kaiser Permanente Sacramento Medical Center — Sacramento
  • Kaiser Permanente-San Francisco — San Francisco
  • Kaiser Permanente-Santa Teresa-San Jose — San Jose
  • Kaiser Permanente San Leandro — San Leandro
  • Kaiser Permanente-San Rafael — San Rafael

Arkansas

  • Highlands Oncology Group - Rogers — Rogers

Trial Details

FieldValue
Enrollment Target 117 participants
Start Date 2010-03-15
Est. Completion 2026-03-19
Phase Phase 1

Sponsor

National Cancer Institute (NCI)

2,390 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT01064648

The ClinicalTrials.gov registry entry for NCT01064648 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 117 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Cancer Institute (NCI), which has 2,390 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 4 conditions, with Pleural Malignant Mesothelioma appearing as the primary indexed condition, and to 5 interventions — of which Cisplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT01064648 reports 20 study locations spanning 2 distinct geographic areas — top geographies include California, Arkansas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT01064648 about?

NCT01064648 is a clinical study titled "Pemetrexed Disodium and Cisplatin With or Without Cediranib Maleate in Treating Patients With Malignant Pleural Mesothelioma". This randomized phase I/II trial is studying the side effects and best dose of cediranib maleate when given together with pemetrexed disodium and cisplatin and to see how well it works in treating patients with malignant pleural mesothelioma. Drugs used in chemotherapy, pemetrexed disodium and cispl...

What is the current status of trial NCT01064648?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 117 participants. The study started on 2010-03-15. Estimated completion is 2026-03-19.

What conditions does trial NCT01064648 study?

This clinical trial studies the following conditions: Pleural Malignant Mesothelioma, Epithelioid Mesothelioma, Recurrent Malignant Mesothelioma, Sarcomatoid Mesothelioma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT01064648?

The interventions under investigation include: Cisplatin (DRUG), Laboratory Biomarker Analysis (OTHER), Placebo Administration (OTHER), Cediranib Maleate (DRUG), Pemetrexed Disodium (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT01064648?

This trial is sponsored by National Cancer Institute (NCI), which has 2,390 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT01064648 being conducted?

This trial has 20 study locations across Arkansas, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial