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NCT02959463 · ClinicalTrials.gov registry record · Phase 1
Pembrolizumab After Radiation Therapy in Treating Patients With Pleural Malignant Mesothelioma
A Phase 1 study of Pleural Malignant Mesothelioma, sponsored by M.D. Anderson Cancer Center.
- Active
- Registry status
- Phase 1
- Development phase
- 24
- Enrollment target
- 1
- Study location
NCT02959463: Active Phase 1 study of Pleural Malignant Mesothelioma, sponsored by M.D. Anderson Cancer Center.
NCT02959463 is a Phase 1 study of Pleural Malignant Mesothelioma that is active but no longer recruiting, run by M.D. Anderson Cancer Center. The registered enrollment target is 24 participants, below the 61-participant average among 4 other Pleural Malignant Mesothelioma trials with a reported enrollment target (61% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02959463, a Phase 1 study of Pleural Malignant Mesothelioma, is active but no longer recruiting, sponsored by M.D. Anderson Cancer Center.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 24 participants
- Enrollment target
- 1
- Study location
Study Summary
This phase I trial studies the side effects and best way to give pembrolizumab after radiation therapy in treating patients with pleural malignant mesothelioma. Radiation therapy uses high energy radiation to kill tumor cells and shrink tumors. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving pembrolizumab after radiation therapy may kill more tumor cells.
Primary Outcome
To determine the safety and tolerability of pembrolizumab administered after radiation therapy in patients with MPM. The primary endpoint was "unaccepable" high grade adverse events (AEs) from baseline to 4-month after the start of radiation therapy.
Conditions Studied
Interventions
- BIOLOGICAL Pembrolizumab
- OTHER Laboratory Biomarker Analysis
- RADIATION Radiation Therapy
- RADIATION Palliative Radiation Therapy
Study Locations (1)
Texas
- M D Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2017-05-01 |
| Est. Completion | 2028-12-31 |
| Phase | Phase 1 |
What the registry record for NCT02959463 still lists
NCT02959463 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 24 participants, a relatively small participant target, below the 61-participant average among 4 other Pleural Malignant Mesothelioma trials with a reported enrollment target (61% lower).
The record links to 1 condition, with Pleural Malignant Mesothelioma appearing as the primary indexed condition, and to 4 interventions - of which Pembrolizumab is the first listed.
NCT02959463 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT02959463 about?
NCT02959463 is a clinical study titled "Pembrolizumab After Radiation Therapy in Treating Patients With Pleural Malignant Mesothelioma". This phase I trial studies the side effects and best way to give pembrolizumab after radiation therapy in treating patients with pleural malignant mesothelioma. Radiation therapy uses high energy radiation to kill tumor cells and shrink tumors. Immunotherapy with monoclonal antibodies, such as pembr...
What is the current status of trial NCT02959463?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 24 participants. The study started on 2017-05-01. Estimated completion is 2028-12-31.
What conditions does trial NCT02959463 study?
This clinical trial studies the following conditions: Pleural Malignant Mesothelioma.
What interventions are being tested in trial NCT02959463?
The interventions under investigation include: Pembrolizumab (BIOLOGICAL), Laboratory Biomarker Analysis (OTHER), Radiation Therapy (RADIATION), Palliative Radiation Therapy (RADIATION).
Who is sponsoring clinical trial NCT02959463?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02959463 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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