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NCT02249039 · ClinicalTrials.gov registry record · Phase 1
Intravenous Clonidine for Sedation in Infants and Children Who Are Mechanically Ventilated - Dosing Finding Study
A Phase 1 study of Mechanical Ventilation Complication, sponsored by Johns Hopkins University.
- Completed
- Registry status
- Phase 1
- Development phase
- 14
- Enrollment target
- 1
- Study location
NCT02249039: Completed Phase 1 study of Mechanical Ventilation Complication, sponsored by Johns Hopkins University.
NCT02249039 is a Phase 1 study of Mechanical Ventilation Complication that has completed, run by Johns Hopkins University. The registered enrollment target is 14 participants, below the 1,187-participant average among 8 other Mechanical Ventilation Complication trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02249039, a Phase 1 study of Mechanical Ventilation Complication, has completed, sponsored by Johns Hopkins University.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 14 participants
- Enrollment target
- 1
- Study location
Study Summary
Critically ill infants and children who are mechanically ventilated are often given large doses of opiates and benzodiazepines to provide analgesia-sedation. These drugs significantly cause tolerance and dependence, depresses the drive to breathe, and thus prolongs the need for mechanical ventilation and the associated complications. We propose IV CLON could be used as effectively as DEX.
Primary Outcome
Time spent (hrs) with a State Behavioral Scale \<1 without the concurrent escalation of opiates or sedatives within 24 hrs after starting the CLON or DEX
Conditions Studied
Interventions
- DRUG intermittent IV CLON
Study Locations (1)
Maryland
- Johns Hopkins Hospital - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 14 participants |
| Start Date | 2015-09 |
| Est. Completion | 2019-12 |
| Phase | Phase 1 |
What the finished NCT02249039 record still lists
NCT02249039 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 14 participants, a relatively small participant target, below the 1,187-participant average among 8 other Mechanical Ventilation Complication trials with a reported enrollment target (99% lower).
The record links to 1 condition, with Mechanical Ventilation Complication appearing as the primary indexed condition, and to 1 intervention - of which intermittent IV CLON is the first listed.
NCT02249039 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT02249039 about?
NCT02249039 is a clinical study titled "Intravenous Clonidine for Sedation in Infants and Children Who Are Mechanically Ventilated - Dosing Finding Study". Critically ill infants and children who are mechanically ventilated are often given large doses of opiates and benzodiazepines to provide analgesia-sedation. These drugs significantly cause tolerance and dependence, depresses the drive to breathe, and thus prolongs the need for mechanical ventilatio...
What is the current status of trial NCT02249039?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 14 participants. The study started on 2015-09. Estimated completion is 2019-12.
What conditions does trial NCT02249039 study?
This clinical trial studies the following conditions: Mechanical Ventilation Complication.
What interventions are being tested in trial NCT02249039?
The interventions under investigation include: intermittent IV CLON (DRUG).
Who is sponsoring clinical trial NCT02249039?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02249039 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Mechanical Ventilation Complication
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02249039's enrollment target sits among peer trials
14 8th of 8 higher than 1 of 8 other Mechanical Ventilation Complication trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Mechanical Ventilation Complication trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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