Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05977153 · ClinicalTrials.gov registry record · NA
CT for Personalized Mechanical Ventilation
A NA study of Mechanical Ventilation Complication and Ventilator-Induced Lung Injury, sponsored by Columbia University.
- Active
- Registry status
- NA
- Development phase
- 7
- Enrollment target
- 1
- Study location
NCT05977153: Active NA study of Mechanical Ventilation Complication and Ventilator-Induced Lung Injury, sponsored by Columbia University.
NCT05977153 is a NA study of Mechanical Ventilation Complication and Ventilator-Induced Lung Injury that is active but no longer recruiting, run by Columbia University. The registered enrollment target is 7 participants, below the 1,188-participant average among 8 other Mechanical Ventilation Complication trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05977153, a NA study of Mechanical Ventilation Complication and Ventilator-Induced Lung Injury, is active but no longer recruiting, sponsored by Columbia University.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 7 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this study is to compare two different ways of helping patients with a condition called sepsis who need help breathing using a machine called a ventilator. The investigators want to study which way of setting the ventilator is better for the lungs. Here are the main questions the investigators want to answer: 1. How does the amount of air in the lungs and the way it moves differ between the two ways? 2. How does the way air spreads out in different parts of the lungs differ between the two ways? In this study, the investigators will take special pictures of the lungs using a machine called a CT scan. The pictures will show us how much the lungs stretch and how much air is in different parts of the lungs. The investigators will compare two different ways of using the ventilator: one personalized for each patient based on their breathing, and another way that is commonly used. By comparing these two ways, the investigators hope to learn which one is better for helping patients with sepsis who need the ventilator. This information can help doctors make better decisions about how to care for these patients and improve their breathing.
Primary Outcome
Squared coefficient of variation (=variance normalized by the squared mean) of the tidal volumetric strain will be obtained and calculated from CT images.
Conditions Studied
Interventions
- PROCEDURE PEEP (positive end-expiratory pressure) - maximum
- PROCEDURE PEEP (positive end-expiratory pressure) - standard
Study Locations (1)
New York
- Columbia University - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 7 participants |
| Start Date | 2023-05-10 |
| Est. Completion | 2027-08-31 |
| Phase | NA |
What the registry record for NCT05977153 still lists
NCT05977153 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 7 participants, a relatively small participant target, below the 1,188-participant average among 8 other Mechanical Ventilation Complication trials with a reported enrollment target (99% lower).
The record links to 3 conditions, with Mechanical Ventilation Complication appearing as the primary indexed condition, and to 2 interventions - of which PEEP (positive end-expiratory pressure) - maximum is the first listed.
NCT05977153 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT05977153 about?
NCT05977153 is a clinical study titled "CT for Personalized Mechanical Ventilation". The goal of this study is to compare two different ways of helping patients with a condition called sepsis who need help breathing using a machine called a ventilator. The investigators want to study which way of setting the ventilator is better for the lungs. Here are the main questions the invest...
What is the current status of trial NCT05977153?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 7 participants. The study started on 2023-05-10. Estimated completion is 2027-08-31.
What conditions does trial NCT05977153 study?
This clinical trial studies the following conditions: Mechanical Ventilation Complication, Ventilator-Induced Lung Injury, Sepsis Syndrome.
What interventions are being tested in trial NCT05977153?
The interventions under investigation include: PEEP (positive end-expiratory pressure) - maximum (PROCEDURE), PEEP (positive end-expiratory pressure) - standard (PROCEDURE).
Who is sponsoring clinical trial NCT05977153?
This trial is sponsored by Columbia University, which has 958 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05977153 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Mechanical Ventilation Complication
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05977153's enrollment target sits among peer trials
7 9th of 8 the lowest of 8 other Mechanical Ventilation Complication trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Mechanical Ventilation Complication trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Volume Support/Assist Control Mode Ventilation and Diaphragmatic Atrophy
RECRUITING · NA
-
Behavioral Economic & Staffing Strategies in the ICU
RECRUITING · NA
-
Efficacy of A Novel RinSe Device to Reduce Oral Bacteria in Intubated IntEnsive CaRe Patients: a Pilot Study
RECRUITING · NA
-
Endotracheal Tube Securement Study
COMPLETED · NA
-
Oxidative Lipidomic Biomarkers During Mechanical Ventilation in Critically Ill Patients (OXY-BAL).
RECRUITING
-
Using Ultrasound to Study Respiratory Muscle Function in Critically Ill Patients
COMPLETED
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI