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NCT00578942 · ClinicalTrials.gov registry record · Phase 2
Allo Non-myeloablative SCT Utilizing Matched Family Member Stem Cells Purged Using Campath
A Phase 2 study of Lymphoma and Leukemia, sponsored by David Rizzieri, MD.
- Completed
- Registry status
- Phase 2
- Development phase
- 48
- Enrollment target
- 1
- Study location
NCT00578942: Completed Phase 2 study of Lymphoma and Leukemia, sponsored by David Rizzieri, MD.
NCT00578942 is a Phase 2 study of Lymphoma and Leukemia that has completed, run by David Rizzieri, MD. The registered enrollment target is 48 participants, below the 484-participant average among 299 other Lymphoma trials with a reported enrollment target (90% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00578942, a Phase 2 study of Lymphoma and Leukemia, has completed, sponsored by David Rizzieri, MD.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 48 participants
- Enrollment target
- 1
- Study location
Study Summary
Allogeneic transplantation is used to treat many malignant and non-malignant diseases, though the potential toxicities of the procedure remain high. We and others have shown that a less toxic preparative regimen allows reliable allogeneic engraftment for allogeneic transplantation. The primary purpose of this treatment trial is to follow subjects undergoing allogeneic transplantation for long term outcomes. The regimen used has been tested in our prior phase I / II trial which has completed accrual. The issues of engraftment and rate of graft versus host disease have been answered and our success has led to this regimen being a standard approach for less toxic allogeneic therapy.
Primary Outcome
Acute graft versus host disease (GVHD) was graded according to the consensus criteria and NCI common terminology criteria for adverse events (CTCAE) v2.0 or 3.0 was used for all other toxicities. Recognizing that acute GVHD pathology in the nonablative and donor lymphocyte infusion (DLI) setting may occur late, we tabulated skin, gut and liver toxicity consistent with acute GVHD (aGVHD) at anytime in the year following the infusion as aGVHD. Toxicities were formally recorded for all patients twi
Conditions Studied
Interventions
- DRUG Campath Purged Non-myeloablative ASCT
Study Locations (1)
North Carolina
- Duke University Health Systems - Durham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2005-05 |
| Est. Completion | 2013-04 |
| Phase | Phase 2 |
What the finished NCT00578942 record still lists
NCT00578942 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 48 participants, a relatively small participant target, below the 484-participant average among 299 other Lymphoma trials with a reported enrollment target (90% lower).
The record links to 5 conditions, with Lymphoma appearing as the primary indexed condition, and to 1 intervention - of which Campath Purged Non-myeloablative ASCT is the first listed.
NCT00578942 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT00578942 about?
NCT00578942 is a clinical study titled "Allo Non-myeloablative SCT Utilizing Matched Family Member Stem Cells Purged Using Campath". Allogeneic transplantation is used to treat many malignant and non-malignant diseases, though the potential toxicities of the procedure remain high. We and others have shown that a less toxic preparative regimen allows reliable allogeneic engraftment for allogeneic transplantation. The primary purp...
What is the current status of trial NCT00578942?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 48 participants. The study started on 2005-05. Estimated completion is 2013-04.
What conditions does trial NCT00578942 study?
This clinical trial studies the following conditions: Lymphoma, Leukemia, Solid Tumors, Myeloma, Myelodysplasia.
What interventions are being tested in trial NCT00578942?
The interventions under investigation include: Campath Purged Non-myeloablative ASCT (DRUG).
Who is sponsoring clinical trial NCT00578942?
This trial is sponsored by David Rizzieri, MD, which has 8 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00578942 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Lymphoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00578942's enrollment target sits among peer trials
48 157th of 299 higher than 141 of 299 other Lymphoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Lymphoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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