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NCT00503451 · ClinicalTrials.gov registry record · Phase 1

A Study to Investigate the Effects of Ketoconazole on LBH589 in Patients With Advanced Solid Tumors

A Phase 1 study of Neoplasms and Non-Hodgkin Lymphoma, sponsored by Novartis Pharmaceuticals.

Completed
Registry status
Phase 1
Development phase
14
Enrollment target
2
Study locations

NCT00503451 is a Phase 1 study of Neoplasms and Non-Hodgkin Lymphoma that has completed, run by Novartis Pharmaceuticals. The registered enrollment target is 14 participants, below the 1,621-participant average among 158 other Neoplasms trials with a reported enrollment target (99% lower). The trial reports 2 study locations across 2 states.

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The verdict

NCT00503451, a Phase 1 study of Neoplasms and Non-Hodgkin Lymphoma, has completed, sponsored by Novartis Pharmaceuticals.

COMPLETED
Registry status
Phase 1
Development phase
14 participants
Enrollment target
2
Study locations

Study Summary

The primary purpose of this open-label study is to investigate the interaction of ketoconazole, a liver enzyme inhibitor, on oral LBH589 in adult patients with advanced solid tumors. The extension phase of the study will evaluate the safety and efficacy of LBH589 in patients with advanced solid tumors.

Conditions Studied

Neoplasms Non-Hodgkin Lymphoma

Interventions

  • DRUG LBH589

Study Locations (2)

Nevada

  • Nevada Cancer Institute - Las Vegas

Other

  • Novartis Investigative Site - Rotterdam

Trial Details

FieldValue
Enrollment Target 14 participants
Start Date 2007-09
Phase Phase 1

Sponsor

Novartis Pharmaceuticals

1,375 total trials

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What the Registry Record Tells You About NCT00503451

The ClinicalTrials.gov registry entry for NCT00503451 describes a study currently listed as completed, categorized as Phase 1. The registered enrollment target is 14 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 1,621-participant average among 158 other Neoplasms trials with a reported enrollment target (99% lower). The listed sponsor is Novartis Pharmaceuticals, which has 1,375 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Neoplasms appearing as the primary indexed condition, and to 1 intervention - of which LBH589 is the first listed.

NCT00503451 reports 2 study locations spanning 2 distinct geographic areas - top geographies include Nevada, Other.

Frequently Asked Questions

What is clinical trial NCT00503451 about?

NCT00503451 is a clinical study titled "A Study to Investigate the Effects of Ketoconazole on LBH589 in Patients With Advanced Solid Tumors". The primary purpose of this open-label study is to investigate the interaction of ketoconazole, a liver enzyme inhibitor, on oral LBH589 in adult patients with advanced solid tumors. The extension phase of the study will evaluate the safety and efficacy of LBH589 in patients with advanced solid tumo...

What is the current status of trial NCT00503451?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 14 participants. The study started on 2007-09.

What conditions does trial NCT00503451 study?

This clinical trial studies the following conditions: Neoplasms, Non-Hodgkin Lymphoma.

What interventions are being tested in trial NCT00503451?

The interventions under investigation include: LBH589 (DRUG).

Who is sponsoring clinical trial NCT00503451?

This trial is sponsored by Novartis Pharmaceuticals, which has 1,375 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT00503451 being conducted?

This trial has 2 study locations across Nevada. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.