Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Preliminary Clinical Activity of RO7673396 in Participants With Advanced Solid Tumors Harboring Rat Sarcoma Viral Oncogene Homolog (RAS) Mutation(s)
NCT06884618 · View on ClinicalTrials.gov ↗
Study Summary
This study aims to evaluate the safety and tolerability of RO7673396 in participants with advanced solid tumors harboring RAS mutation(s). This study consists of two stages: Stage 1 (Dose Escalation) and Stage 2 (Dose Expansion). Stage 1 will define the recommended dose(s) for expansion (RDEs) of RO7673396. Stage 2 will evaluate preliminary anti-tumor activity of the RDE(s) defined in Stage 1 and of other doses of interest for future development in selected solid tumor indications.
Conditions Studied
Interventions
- DRUG RO7673396
Study Locations (19)
Other
- Sun Yat-Sen University Cancer Center;Department of Thoracic Surgery — Guangzhou
- Fudan University Shanghai Cancer Center — Shanghai
- Hubei Cancer Hospital — Wuhan
- Prince of Wales Hospital — Hong Kong
- New Zealand Clinical Research - Auckland — Auckland
- New Zealand Clinical Research - Christchurch — Christchurch
- National Cancer Centre - 30 Hospital Blvd — Singapore
- National Cheng Kung University Hospital — Tainan
- National Taiwan University Hospital — Taipei
Texas
- MD Anderson Cancer Center — Houston
- South Texas Accelerated Research Therapeutics (START) — San Antonio
California
- City of Hope Comprehensive Cancer Center — Duarte
Colorado
- University of Colorado - Anschutz Medical Campus - PPDS — Aurora
Connecticut
- Smilow Cancer Hospital at Yale New Haven — New Haven
Florida
- Florida Cancer Specialists - Sarasota (North Catttlemen Rd) — Sarasota
New South Wales
- St Vincent's Hospital Sydney — Darlinghurst
Victoria
- Peter MacCallum Cancer Center — Parkville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 345 participants |
| Start Date | 2025-04-30 |
| Est. Completion | 2029-05-25 |
| Phase | Phase 1 |
Interested in This Trial?
Always speak with your doctor before enrolling in a clinical trial.
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06884618
The ClinicalTrials.gov registry entry for NCT06884618 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 345 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Hoffmann-La Roche, which has 758 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Neoplasms appearing as the primary indexed condition, and to 1 intervention — of which RO7673396 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06884618 reports 19 study locations spanning 10 distinct geographic areas — top geographies include Other, Texas, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06884618 about?
NCT06884618 is a clinical study titled "A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Preliminary Clinical Activity of RO7673396 in Participants With Advanced Solid Tumors Harboring Rat Sarcoma Viral Oncogene Homolog (RAS) Mutation(s)". This study aims to evaluate the safety and tolerability of RO7673396 in participants with advanced solid tumors harboring RAS mutation(s). This study consists of two stages: Stage 1 (Dose Escalation) and Stage 2 (Dose Expansion). Stage 1 will define the recommended dose(s) for expansion (RDEs) of RO...
What is the current status of trial NCT06884618?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 345 participants. The study started on 2025-04-30. Estimated completion is 2029-05-25.
What conditions does trial NCT06884618 study?
This clinical trial studies the following conditions: Neoplasms. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06884618?
The interventions under investigation include: RO7673396 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06884618?
This trial is sponsored by Hoffmann-La Roche, which has 758 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06884618 being conducted?
This trial has 19 study locations across California, Colorado, Connecticut, Florida, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How Clinical Trials Work
Understand phases 1-4, trial design, randomization, and the informed consent process.
Patient Rights in Clinical Trials
Your rights as a participant: consent, withdrawal, privacy, and who to contact.
Finding the Right Clinical Trial
A practical guide to searching trials, understanding eligibility, and evaluating options.
All Guides
Browse our complete library of clinical trial educational resources.
Read our methodology — how this data is sourced, computed, and verified.