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A Study of GSK5764227 in Participants With. Advanced Solid Tumors (EMBOLD PanTumor-101)
NCT06551142 · View on ClinicalTrials.gov ↗
Study Summary
The goal of this study is to assess the safety, tolerability, clinical activity and pharmacokinetics of GSK5764227. The study will also see how the levels of GSK5764227 will change over time at different dose amounts when administered alone and in combination with other medicines like carboplatin, cisplatin, atezolizumab, pembrolizumab, durvalumab, bevacizumab, cetuximab.
Conditions Studied
Interventions
- BIOLOGICAL Pembrolizumab
- DRUG Carboplatin
- BIOLOGICAL Atezolizumab
- DRUG Cisplatin
- BIOLOGICAL GSK5764227
Study Locations (20)
Texas
- GSK Investigational Site — Austin
- GSK Investigational Site — Dallas
- GSK Investigational Site — San Antonio
- GSK Investigational Site — Tyler
Other
- GSK Investigational Site — Rosario
- GSK Investigational Site — Viedma
Ontario
- GSK Investigational Site — Ottawa
- GSK Investigational Site — Toronto
Quebec
- GSK Investigational Site — Montreal
- GSK Investigational Site — Sherbrooke
California
- GSK Investigational Site — Stanford
Colorado
- GSK Investigational Site — Denver
Connecticut
- GSK Investigational Site — New Haven
Massachusetts
- GSK Investigational Site — Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 590 participants |
| Start Date | 2024-09-30 |
| Est. Completion | 2027-05-19 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06551142
The ClinicalTrials.gov registry entry for NCT06551142 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 590 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is GlaxoSmithKline, which has 558 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Neoplasms appearing as the primary indexed condition, and to 5 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06551142 reports 20 study locations spanning 14 distinct geographic areas — top geographies include Texas, Other, Ontario. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06551142 about?
NCT06551142 is a clinical study titled "A Study of GSK5764227 in Participants With. Advanced Solid Tumors (EMBOLD PanTumor-101)". The goal of this study is to assess the safety, tolerability, clinical activity and pharmacokinetics of GSK5764227. The study will also see how the levels of GSK5764227 will change over time at different dose amounts when administered alone and in combination with other medicines like carboplatin, c...
What is the current status of trial NCT06551142?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 590 participants. The study started on 2024-09-30. Estimated completion is 2027-05-19.
What conditions does trial NCT06551142 study?
This clinical trial studies the following conditions: Neoplasms. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06551142?
The interventions under investigation include: Pembrolizumab (BIOLOGICAL), Carboplatin (DRUG), Atezolizumab (BIOLOGICAL), Cisplatin (DRUG), GSK5764227 (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06551142?
This trial is sponsored by GlaxoSmithKline, which has 558 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06551142 being conducted?
This trial has 20 study locations across California, Colorado, Connecticut, Massachusetts, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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