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NCT00109642 · ClinicalTrials.gov registry record
The Role of Norepinephrine in Emotional Processing
A clinical trial of Mental Disorders and Psychopathy, sponsored by National Institute of Mental Health (NIMH).
- Completed
- Registry status
- 216
- Enrollment target
- 1
- Study location
NCT00109642: Completed study of Mental Disorders and Psychopathy, sponsored by National Institute of Mental Health (NIMH).
NCT00109642 is a study of Mental Disorders and Psychopathy that has completed, run by National Institute of Mental Health (NIMH). The registered enrollment target is 216 participants, below the 676-participant average among 25 other Mental Disorders trials with a reported enrollment target (68% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00109642, a study of Mental Disorders and Psychopathy, has completed, sponsored by National Institute of Mental Health (NIMH).
- COMPLETED
- Registry status
- 216 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will examine the role of a brain chemical called norepinephrine in thinking, decision-making, and emotional processing. After norepinephrine is released from a brain cell, it binds to another brain cell's receptor. Some of the receptors it binds to are called alpha-2 adrenergic receptors. This study will use medicines called yohimbine and guanfacine to look at the function of norepinephrine in the brain when it binds to the alpha-2 adrenergic receptors. Yohimbine increases norepinephrine's function and guanfacine decreases its function. Healthy volunteers between 20 and 50 years of age who do not have heart disease, high blood pressure, psychiatric illness, or other serious medical conditions and who are not allergic to lactose may be eligible for this study. Candidates are screened with a medical and psychiatric history, physical examination, neuropsychological testing, blood and urine tests and electrocardiogram. Women are screened with a urine pregnancy test. Participants are given a pill of yohimbine, guanfacine, or placebo and undergo the following tests and procedures: * Blood pressure and heart rate measurements: Blood pressure and heart rate are measured before the medication is taken and several times after. * Blood draws: Blood is drawn before the medicine is taken and 90 minutes after to measure levels of norepinephrine and the hormone cortisol. * Neurocognitive testing: Participants do neurocognitive tasks on the computer for up to 90 minutes. The tasks involve looking at pictures or words on a screen and responding according to instructions given. * Magnetic resonance imaging (MRI): Patients may undergo neurocognitive testing MRIs. This test uses a strong magnetic field and radio waves to show changes in brain activity. The subject lies on a table that slides into a narrow cylinder (the MRI scanner). Images of the brain are obtained while the subject performs the computer tasks.
Conditions Studied
Study Locations (1)
Maryland
- National Institutes of Health Clinical Center, 9000 Rockville Pike - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 216 participants |
| Start Date | 2005-04-26 |
| Est. Completion | 2009-03-15 |
What the finished NCT00109642 record still lists
NCT00109642 is an observational study that tracks outcomes without assigning an intervention. The registered 216 participants enrollment target is mid-sized for trials with a published cap, below the 676-participant average among 25 other Mental Disorders trials with a reported enrollment target (68% lower).
The record links to 2 conditions, with Mental Disorders appearing as the primary indexed condition, and to 0 interventions.
NCT00109642 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT00109642 about?
NCT00109642 is a clinical study titled "The Role of Norepinephrine in Emotional Processing". This study will examine the role of a brain chemical called norepinephrine in thinking, decision-making, and emotional processing. After norepinephrine is released from a brain cell, it binds to another brain cell's receptor. Some of the receptors it binds to are called alpha-2 adrenergic receptors....
What is the current status of trial NCT00109642?
This trial is currently completed. The enrollment target is 216 participants. The study started on 2005-04-26. Estimated completion is 2009-03-15.
What conditions does trial NCT00109642 study?
This clinical trial studies the following conditions: Mental Disorders, Psychopathy.
Who is sponsoring clinical trial NCT00109642?
This trial is sponsored by National Institute of Mental Health (NIMH), which has 343 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00109642 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT00109642's enrollment target sits among peer trials
216 12th of 25 higher than 14 of 25 other Mental Disorders trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Mental Disorders trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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