University of North Carolina, Chapel Hill

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, University of North Carolina, Chapel Hill sits in the top decile of US sponsors by registered trial count (#28 of 15,742 sponsors by registered trial count).

1,109 total trials 108 currently recruiting 881 completed early-phase tilt top decile by trial count

University of North Carolina, Chapel Hill: 1,109 sponsored US clinical trials, 108 recruiting.

University of North Carolina, Chapel Hill sponsors 1,109 registered US clinical trials on ClinicalTrials.gov, 108 of them currently recruiting, and 881 completed. 69 of these trials are in Phase 3-4 (later-stage) and 203 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Obesity, with 17 trials.

Top-decile sponsor footprint

University of North Carolina, Chapel Hill ranks in the top decile of sponsors by registered trial count (#28 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

C 69/100

881 of 962 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (91.6%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

1,109 total, page 20 of 23

TERMINATED Phase 4

Oral Metolazone and Intermittent Intravenous Furosemide Versus Continuous Infusion Furosemide in Acute Heart Failure

NCT00904488

COMPLETED Phase 1

Pharmacokinetic Study of Raltegravir in Healthy Premenopausal Women.

NCT00746499

COMPLETED NA

Behavioral Depression Treatment for African American HIV-infected Substance Users

NCT01351454

COMPLETED NA

Treatment for Periodontal Disease in Dialysis Patients

NCT00937976

COMPLETED Phase 2

Effectiveness of Metformin Compared to Insulin in Pregnant Women With Mild Preexisting or Early Gestational Diabetes

NCT00835861

COMPLETED NA

Genotype-Guided Warfarin Therapy Trial

NCT00904293

COMPLETED NA

Once Weekly Subcutaneous Ports for the Administration of Anticoagulants

NCT00774748

TERMINATED Phase 1

Range of Neutrophil Response to 20,000 EU of Clinical Center Reference Endotoxin in Otherwise Healthy Smokers

NCT00753870

COMPLETED

Long-term Lung Function and Disease Progression in Children With Early Onset Primary Ciliary Dyskinesia Lung Disease

NCT00722878

COMPLETED Phase 4

Continuous Oral Contraceptive Treatment in Premenstrual Dysphoric Disorder (PMDD)

NCT00927095

COMPLETED

Validation of PROMIS Banks With COPD Exacerbations

NCT00784342

COMPLETED NA

A Randomized Controlled Trial (RCT) of Carbon Dioxide Versus Air Insufflation During Endoscopic Retrograde Cholangiopancreatography (ERCP)

NCT00685386

COMPLETED

Hemostatic Textile to Control Bleeding at Donor Graft Sites

NCT00855569

COMPLETED Phase 1

Effect of Gamma Tocopherol Supplementation on Neutrophil Response to 20,000 EU of Clinical Center Reference Endotoxin in Normal Adults

NCT00631085

COMPLETED

HIV Treatment-Readiness Measure (HTRM) Validation

NCT00686049

COMPLETED NA

Improving Representative Payeeship for People With Psychiatric Disabilities and Their Families

NCT00924976

COMPLETED Phase 2

Ciprofloxacin for the Prevention of Postoperative Endoscopic Recurrence in Crohn's Disease

NCT00609973

COMPLETED Phase 1

Study in Healthy Males to Measure Maraviroc in Blood, Saliva, Seminal Fluid, and Rectal Tissue

NCT00775294

TERMINATED Phase 1

Safety Study of 20,000 EU of Clinical Center Reference Endotoxin in Allergic Adults With and Without Mild Asthma

NCT00630461

COMPLETED NA

Nurture: A Program for Mothers With Histories of Disordered Eating

NCT00877994

COMPLETED NA

Online Cognitive Behavioral Therapy for Bulimia Nervosa

NCT00877786

COMPLETED NA

UCAN: Uniting Couples in the Treatment of Anorexia Nervosa

NCT00928109

COMPLETED

Time to Conceive: A Study of Fertility

NCT01028365

COMPLETED NA

Integrated Treatment of Marijuana Abuse for HIV+ Youth

NCT00683488

COMPLETED

Linkage to Care - Part I

NCT00703040

COMPLETED

Psychosocial Needs of YMSM

NCT00710671

COMPLETED

Myfortic Conversion Trial in OLT Recipients With GI Intolerance

NCT00619216

COMPLETED NA

Trial of a Water Beverage Intervention for Promoting Modest Weight Reduction in Free Living Adults

NCT01017783

TERMINATED NA

Feasibility Study of Vessel Analysis for Noninvasive Diagnosis of Malignancy in Breast Tumors

NCT00630292

COMPLETED Phase 2

Impact of a Human Papilloma Virus (HPV) Vaccine in HIV-Infected Young Women

NCT00710593

COMPLETED

Development of a Questionnaire to Measure Hypervigilance for Visceral Pain

NCT01166802

COMPLETED NA

Open Label Seroquel (Quetiapine) Study for Treatment Resistant Functional Bowel Disorder

NCT00617396

COMPLETED Phase 1

Lubiprostone Effects on Visceral Pain Sensitivity

NCT01166789

COMPLETED NA

Child Care Wellness Study on Nutrition and Physical Activity

NCT01921842

COMPLETED NA

Effects of Diesel Exhaust Followed by Administration of Nasal Spray Flu Vaccine on Individuals With & Without Allergies

NCT00617110

COMPLETED Phase 2

A Study of Sublingual Immunotherapy in Peanut-allergic Children

NCT00597727

COMPLETED

Third Molar Clinical Trials: Pericoronitis Studies

NCT01882270

COMPLETED Phase 1

Pounds Off Digitally Study: A Podcasting Weight Loss Intervention

NCT00771095

COMPLETED NA

The Effects of a Self-management Intervention on Low Literacy Patients With Chronic Obstructive Pulmonary Disease (COPD)

NCT01327456

COMPLETED NA

Efficacy of Cantharidin in Molluscum Contagiosum

NCT00667225

COMPLETED NA

Feasibility and Effects of Preventive Home Visits for Older Adults

NCT00985283

COMPLETED NA

Vitamin D Reabsorption in Adolescents and Young Adults With HIV Infection

NCT00490412

COMPLETED

Neurocognitive Assessment in Youth Initiating HAART

NCT00683579

COMPLETED

Epigenetics, DNA Methylation Patterns and Periodontal Disease

NCT01399034

COMPLETED NA

Preservation and Expansion of T-cell Subsets Following HAART De-intensification to Atazanavir/Ritonavir (ATV/r)

NCT00491556

COMPLETED NA

Characterization of Interferon Beta -1b-Induced Tolerizing Effect in Dendritic Cells

NCT00630721

COMPLETED

Microbicides Acceptability Among Sexually Active Young Women

NCT00490152

COMPLETED

Effect of Antipsychotics on Appetite Regulation

NCT00903916

COMPLETED NA

Sharing Our Strength: A Research Study for Bone Marrow/Stem Cell Transplant Survivors

NCT00701844

COMPLETED NA

Human Requirements for the Nutrient Choline

NCT00065546

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Phase Distribution

PhaseTrial count
Phase 1 111
Phase 2 92
Phase 3 13
Phase 4 56

What is open in the University of North Carolina, Chapel Hill pipeline

108 recruiting of 1,109 indexed (10% open); 881 completed (79%).

Phase mix: 69 late (III/IV) vs 203 early (I/II) (early-phase heavy).

Top condition: Obesity (17 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

University of North Carolina, Chapel Hill: open-pipeline peers nationwide

Peers matched on 1,109 registered trials and 10% open enrollment, not the therapeutic-area sidebar.

University of North Carolina, Chapel Hill sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 05001,0001,500 8%10%12%14%16%18%20% Total trials Recruiting share University of North Carolina, Chapel HillUniversity of FloridaWake Forest University Health SciencesUniversity of Alabama at BirminghamNYU Langone HealthChildren's Hospitals and Clinics of MinnesotaCytokineticsSanofiOhio University
University of North Carolina, Chapel Hill sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

University of North Carolina, Chapel Hill sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 1,109 trials (± recruiting share)

Sponsors near 10% open enrollment (± trial volume)

What to do with this University of North Carolina, Chapel Hill page

1,109 registered trials is a research-attention snapshot, not an endorsement of University of North Carolina, Chapel Hill or any single study.

  • 108 of University of North Carolina, Chapel Hill's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Obesity is the condition University of North Carolina, Chapel Hill studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Obesity trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. University of North Carolina, Chapel Hill pipeline card: 1,109 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.