UNC Lineberger Comprehensive Cancer Center

366 total trials 79 currently recruiting 209 completed

UNC Lineberger Comprehensive Cancer Center sponsors 366 registered US clinical trials on ClinicalTrials.gov, 79 of them currently recruiting, and 209 completed. 2 of these trials are in Phase 3-4 (later-stage) and 157 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Breast Cancer, with 29 trials.

Trial Pipeline

366 total, page 6 of 8

COMPLETED

Investigation of Circulating Tumor Cells From Cancer Patients Undergoing Radiation Therapy

NCT02449837

COMPLETED

The Impact of a Physical Activity Program on Biomarkers of Aging During Chemotherapy for Breast Cancer

NCT02167932

COMPLETED Phase 2

Metformin With the Levonorgestrel-Releasing Intrauterine Device for the Treatment of Complex Atypical Hyperplasia (CAH) and Endometrial Cancer (EC) in Non-surgical Patients

NCT02035787

COMPLETED NA

Evaluation of the Lung Nodule Sensitivity of Stationary Chest Tomosynthesis in Patients With Known Lung Nodules

NCT02075320

COMPLETED

Observational Longitudinal Study of Pain in Men With Metastatic Castrate-Resistant Prostate Cancer

NCT02008058

COMPLETED NA

Exercise and Quality of Life in Leukemia Patients

NCT02246907

COMPLETED NA

The Use of Smart Scales for Weight Gain Prevention in African American Breast Cancer Survivors

NCT02030353

COMPLETED NA

Improving Survivorship Care Through Enhanced Communication and Coordination: Pilot Study

NCT02111616

TERMINATED Phase 1

Neoadjuvant Chemoradiotherapy With CRLX-101 and Capecitabine for Rectal Cancer

NCT02010567

TERMINATED NA

Monitoring of Oral Human Papillomavirus Infection (HPV) in HPV-positive Oropharyngeal Squamous Cell Carcinoma (OPSCC)

NCT02045186

TERMINATED

Using Walk With Ease Walking Program With Men 65 and Older Being Treated for Prostate Cancer

NCT02139774

COMPLETED

Radiation Adherence/Toxicity in Patients With Non-Ovarian Gynecological Cancers

NCT02003430

TERMINATED

Pilot Study: Utilizing Manometry to Assess Radiation-Induced Changes in Esophageal Function

NCT01992068

COMPLETED Early Phase 1

Defining the HER2 Positive (+) Breast Cancer Kinome Response to Trastuzumab, Pertuzumab, Combination Trastuzumab +Pertuzumab, or Combination Trastuzumab + Lapatinib

NCT01875666

COMPLETED Phase 2

Single Arm on the Tolerability of Weekly Nab-paclitaxel

NCT01702844

COMPLETED Phase 1

Effect of Curcumin on Dose Limiting Toxicity and Pharmacokinetics of Irinotecan in Patients With Solid Tumors

NCT01859858

COMPLETED NA

Evaluation of Cardiorespiratory Performance After Interval Exercise Training Prior to Hematopoietic Cell Transplantation

NCT02577939

COMPLETED Early Phase 1

Open-label Pilot Evaluating Renal Lesions w/ Contrast-enhaced US in Patients w/ Renal Cancer

NCT01751529

COMPLETED Phase 2

LCCC 1128: Open Label Phase II Trial of the BRAF Inhibitor (Dabrafenib) and the MEK Inhibitor (Trametinib) in Unresectable Stage III and Stage IV BRAF Mutant Melanoma; Correlation of Resistance With the Kinome and Functional Mutations

NCT01726738

COMPLETED

Assessment of Ability of Breath Hold for Left-sided Breast Cancer Radiation Therapy to Reduce Side Effects to Heart

NCT01849614

COMPLETED

PET/MRI in CNS and Extra-CNS Tumors of Patients With Neurofibromatosis-1 (NF1)

NCT01800032

COMPLETED Early Phase 1

Metformin for the Treatment of Endometrial Hyperplasia

NCT01685762

COMPLETED

Comparison of Stationary Breast Tomosynthesis and 2-D Digital Mammography in Patients With Known Breast Lesions

NCT01773850

COMPLETED Phase 2

Stereotactic Radiosurgery or Other Local Ablation Then Erlotinib in Epidermal Growth Factor Receptor (EGFR)

NCT01573702

COMPLETED

Predicting Tolerance to Radiation Therapy in Older Adults With Cancer

NCT01752751

COMPLETED

PET/MRI as a Predictor of Response to Pre-op Chemoradiation in Resectable Rectal Cancer: a Pilot Study

NCT01751516

COMPLETED

Feasibility of an Evidence-based Walking Program in Cancer Pts 60+ During Chemotherapy

NCT01789983

COMPLETED

Hybrid PET/MR in the Therapy of Cervical Cancer

NCT01759355

COMPLETED NA

Imaging Correlates of Renal Cell Carcinoma Biological Features

NCT01665703

COMPLETED NA

Positron Emission Tomography (PET) Study for Staging of Muscle Invasive Bladder Cancer

NCT01655745

COMPLETED

Study of Outcomes After Surgery/Treatment to Treat Bladder Cancer

NCT01776138

COMPLETED

Finding Predictors of Side Effects to Chemoradiation Treatment in Elderly Patients With Head and Neck Cancer

NCT01688323

COMPLETED Phase 1

Lenalidomide as Consolidation and Maintenance in Adults >/= 60 Years of Age With AML Following Standard Induction

NCT01578954

COMPLETED Phase 2

Multimodality Risk Adapted Tx Including Induction Chemo for SCCHN Amenable to Transoral Surgery

NCT01612351

COMPLETED

Cardiovascular Risk and Preventive Care in Prostate Cancer Patients Receiving Radiation and Hormone Therapy

NCT02003417

COMPLETED

Patient Preferences for Breast Reconstruction After Mastectomy

NCT01488357

COMPLETED Phase 1

BKM120 + mFOLFOX6 in Advanced Solid Tumors With Expansion Cohort Pancreatic Cancer

NCT01571024

COMPLETED NA

Induction Chemo w/ABVD Followed by Brentuximab Vedotin Consolidation in Newly Diagnosed, Non-Bulky Stage I/II Hodgkin Lymphoma

NCT01578967

COMPLETED Phase 2

De-intensification of Radiation & Chemotherapy in Low-Risk Human Papillomavirus-related Oropharyngeal Squamous Cell Ca

NCT01530997

COMPLETED Phase 2

Induction Chemotherapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck

NCT01412229

COMPLETED Early Phase 1

Defining the Triple Negative Breast Cancer Kinome Response to GSK1120212

NCT01467310

TERMINATED Phase 2

FOLFIRINOX for Unresectable Locally Advanced and Borderline Resectable Pancreatic Cancer

NCT01688336

COMPLETED

Circulating Tumor Cells in Solid Tumors

NCT03161821

COMPLETED Phase 2

Everolimus and Pasireotide (SOM230) in Patients With Advanced or Metastatic Hepatocellular Carcinoma

NCT01488487

COMPLETED Phase 2

A Study Of Everolimus, Trastuzumab And Vinorelbine In HER2-Positive Breast Cancer Brain Metastases

NCT01305941

COMPLETED NA

Development of a Tumor Molecular Analyses Program and Its Use to Support Treatment Decisions

NCT01457196

COMPLETED Phase 1

Study of BKM120 or BYL719 and Capecitabine in Patients With Metastatic Breast Cancer

NCT01300962

COMPLETED Phase 2

Neoadjuvant Pazopanib in Renal Cell Carcinoma

NCT01361113

COMPLETED Phase 1

Bavituximab Plus Carbo and Pemetrexed in Chemo-Naive Stage IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC) Subjects

NCT01323062

COMPLETED Early Phase 1

Preoperative Window Study of Metformin for the Treatment of Endometrial Cancer

NCT01911247

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Phase Distribution

PhaseTrial count
Phase 1 71
Phase 2 86
Phase 3 1
Phase 4 1

What the Pipeline for UNC Lineberger Comprehensive Cancer Center Shows

According to the ClinicalTrials.gov registry, UNC Lineberger Comprehensive Cancer Center is linked to 366 US clinical trials across every stage of research activity. Of those, 79 studies are currently recruiting, about 22% of the sponsor's indexed portfolio, and 209 are already marked complete, representing roughly 57% of the total.

The phase mix for UNC Lineberger Comprehensive Cancer Center reports 2 late-stage studies (Phase 3 and Phase 4 combined) and 157 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for UNC Lineberger Comprehensive Cancer Center is Breast Cancer with 29 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.