OPKO Health

32 total trials 25 completed

OPKO Health sponsors 32 registered US clinical trials on ClinicalTrials.gov, none currently recruiting, and 25 completed. 4 of these trials are in Phase 3-4 (later-stage) and 27 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Growth Hormone Deficiency (GHD), with 1 trials.

Trial Pipeline

32 total, page 1 of 1

NOT YET RECRUITING Phase 2

Pharmacokinetics, Pharmacodynamics, Safety and Tolerability Evaluation of CTAP101 Extended-release Capsules in Pediatric Participants

NCT07494045

TERMINATED Phase 3

Phase 3 Safety and Efficacy Study of CTAP101 Extended-release Capsules in Children With Secondary Hyperparathyroidism

NCT05543928

COMPLETED Phase 2

Safety and Efficacy of Rayaldee for Treating Mild to Moderate COVID-19

NCT04551911

COMPLETED Phase 1

A Clinical Study Investigating the Comparability of Somatrogon in Two Different Drug Product Presentations

NCT03810664

COMPLETED Phase 1

Pharmacokinetics and Safety Study of CTAP101 Capsules in Japanese and Non-Japanese Healthy Subjects and Non-Japanese Healthy Subjects

NCT03660800

TERMINATED Phase 2

Safety, Efficacy, PK and PD of CTAP101 (Calcifediol) ER Capsules for SHPT in HD Patients VDI

NCT03602261

COMPLETED Phase 4

Repeated-dose Safety, Efficacy, Pharmacokinetic and Pharmacodynamic of CTAP101, Immediate-release Calcifediol, High-dose Cholecalciferol, and Paricalcitol Plus Low-dose Cholecalciferol in Patients With Secondary Hyperparathyroidism, Chronic Kidney Disease 3-4 and Vitamin D Insufficiency

NCT03588884

COMPLETED Phase 2

Effects and Safety of OPK-88003 Dose Escalation in Type 2 Diabetes Subjects

NCT03406377

TERMINATED Phase 2

Effects and Safety of OPK-88004 Doses in Men With Signs and Symptoms of Benign Prostatic Hyperplasia (BPH)

NCT03297398

COMPLETED

4Kscore Using Serum Stored Uncentrifuged

NCT04130776

COMPLETED Phase 3

Safety and Efficacy Phase 3 Study of Long-acting hGH (MOD-4023) in Growth Hormone Deficient Children

NCT02968004

COMPLETED Phase 1

A Study of a Long-Acting r-Factor 7a (Factor VIIa) in Adult Men With Hemophilia A or B

NCT02418793

COMPLETED Phase 1

Pharmacokinetics and Pharmacodynamics of Long Acting Human Growth Hormone (hGH) Product (MOD-4023) in Healthy Caucasian and Japanese Volunteers

NCT02418767

COMPLETED Phase 1

Effect of CTAP101 Capsules on Ca/iPTH in Advanced Breast/Prostate Cancer Patients Treated With Denosumab/Zoledronic Acid

NCT02274623

COMPLETED Phase 2

A Study to Compare a New Drug for Type 2 Diabetes to Placebo and to a Treatment Already Available for Type 2 Diabetes

NCT02119819

COMPLETED Phase 2

Long Term Follow up Study of Long-acting hGH (MOD-4023) in Growth Hormone Deficient Children

NCT02500316

COMPLETED Phase 2

A 4-Week Safety Study of Oral ELND005 in Young Adults With Down Syndrome Without Dementia

NCT01791725

TERMINATED Phase 2

A 36-Week Safety Extension Study of ELND005 as a Treatment for Agitation and Aggression in Alzheimer's Disease

NCT01766336

COMPLETED Phase 2

Efficacy and Safety Study of ELND005 as a Treatment for Agitation and Aggression in Alzheimer's Disease

NCT01735630

TERMINATED Phase 2

Safety and Efficacy Study of ELND005 as an Adjunctive Maintenance Treatment in Bipolar I Disorder

NCT01674010

COMPLETED Phase 1

Effects of TT301 on Cytokine Levels Post Endotoxin Challenge

NCT01357421

COMPLETED Phase 2

Safety/Efficacy Study of CTAP101 in Chronic Kidney Disease Subjects With Secondary Hyperparathyroidism (SHPT)

NCT01219855

COMPLETED Phase 2

ELND005 Long-Term Follow-up Study in Subjects With Alzheimer's Disease

NCT00934050

COMPLETED Phase 2

A Trial of TT223 in Patients With Type 2 Diabetes Who Are Taking Metformin and/or Thiazolidinedione

NCT00743002

COMPLETED Phase 2

ELND005 in Patients With Mild to Moderate Alzheimer's Disease

NCT00568776

TERMINATED Phase 3

Safety & Efficacy Study Evaluating the Combination of Bevasiranib & Lucentis Therapy in Wet AMD

NCT00499590

COMPLETED Phase 2

Safety and Efficacy of Topically Applied CTA018 in Plaque Psoriasis

NCT00384098

COMPLETED Phase 2

Safety and Efficacy Study of Small Interfering RNA Molecule (Cand5) to Treat Diabetic Macular Edema

NCT00306904

COMPLETED Phase 1

A Study in Type 2 Diabetic Patients With Repeated Doses of E1 in Combination With G1

NCT00239187

COMPLETED Phase 2

Safety and Efficacy Study of Small Interfering Ribonucleic Acid (RNA) Molecule (Cand5) to Treat Wet Age-Related Macular Degeneration

NCT00259753

COMPLETED Phase 1

A Study in Type 1 Diabetic Patients With Repeated Doses of E1 in Combination With G1

NCT00239148

COMPLETED Phase 1

Open Label Study for the Evaluation of Tolerability of Five Dose Levels of Cand5

NCT00722384

Phase Distribution

PhaseTrial count
Phase 1 9
Phase 2 18
Phase 3 3
Phase 4 1

What the Pipeline for OPKO Health Shows

According to the ClinicalTrials.gov registry, OPKO Health is linked to 32 US clinical trials across every stage of research activity. Of those, 0 studies are currently recruiting, about 0% of the sponsor's indexed portfolio, and 25 are already marked complete, representing roughly 78% of the total.

The phase mix for OPKO Health reports 4 late-stage studies (Phase 3 and Phase 4 combined) and 27 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for OPKO Health is Growth Hormone Deficiency (GHD) with 1 linked trial, and 4 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.