OPKO Health
OPKO Health sponsors 32 registered US clinical trials on ClinicalTrials.gov, none currently recruiting, and 25 completed. 4 of these trials are in Phase 3-4 (later-stage) and 27 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Growth Hormone Deficiency (GHD), with 1 trials.
Trial Pipeline
32 total, page 1 of 1
Pharmacokinetics, Pharmacodynamics, Safety and Tolerability Evaluation of CTAP101 Extended-release Capsules in Pediatric Participants
NCT07494045
Phase 3 Safety and Efficacy Study of CTAP101 Extended-release Capsules in Children With Secondary Hyperparathyroidism
NCT05543928
Safety and Efficacy of Rayaldee for Treating Mild to Moderate COVID-19
NCT04551911
A Clinical Study Investigating the Comparability of Somatrogon in Two Different Drug Product Presentations
NCT03810664
Pharmacokinetics and Safety Study of CTAP101 Capsules in Japanese and Non-Japanese Healthy Subjects and Non-Japanese Healthy Subjects
NCT03660800
Safety, Efficacy, PK and PD of CTAP101 (Calcifediol) ER Capsules for SHPT in HD Patients VDI
NCT03602261
Repeated-dose Safety, Efficacy, Pharmacokinetic and Pharmacodynamic of CTAP101, Immediate-release Calcifediol, High-dose Cholecalciferol, and Paricalcitol Plus Low-dose Cholecalciferol in Patients With Secondary Hyperparathyroidism, Chronic Kidney Disease 3-4 and Vitamin D Insufficiency
NCT03588884
Effects and Safety of OPK-88003 Dose Escalation in Type 2 Diabetes Subjects
NCT03406377
Effects and Safety of OPK-88004 Doses in Men With Signs and Symptoms of Benign Prostatic Hyperplasia (BPH)
NCT03297398
4Kscore Using Serum Stored Uncentrifuged
NCT04130776
Safety and Efficacy Phase 3 Study of Long-acting hGH (MOD-4023) in Growth Hormone Deficient Children
NCT02968004
A Study of a Long-Acting r-Factor 7a (Factor VIIa) in Adult Men With Hemophilia A or B
NCT02418793
Pharmacokinetics and Pharmacodynamics of Long Acting Human Growth Hormone (hGH) Product (MOD-4023) in Healthy Caucasian and Japanese Volunteers
NCT02418767
Effect of CTAP101 Capsules on Ca/iPTH in Advanced Breast/Prostate Cancer Patients Treated With Denosumab/Zoledronic Acid
NCT02274623
A Study to Compare a New Drug for Type 2 Diabetes to Placebo and to a Treatment Already Available for Type 2 Diabetes
NCT02119819
Long Term Follow up Study of Long-acting hGH (MOD-4023) in Growth Hormone Deficient Children
NCT02500316
A 4-Week Safety Study of Oral ELND005 in Young Adults With Down Syndrome Without Dementia
NCT01791725
A 36-Week Safety Extension Study of ELND005 as a Treatment for Agitation and Aggression in Alzheimer's Disease
NCT01766336
Efficacy and Safety Study of ELND005 as a Treatment for Agitation and Aggression in Alzheimer's Disease
NCT01735630
Safety and Efficacy Study of ELND005 as an Adjunctive Maintenance Treatment in Bipolar I Disorder
NCT01674010
Effects of TT301 on Cytokine Levels Post Endotoxin Challenge
NCT01357421
Safety/Efficacy Study of CTAP101 in Chronic Kidney Disease Subjects With Secondary Hyperparathyroidism (SHPT)
NCT01219855
ELND005 Long-Term Follow-up Study in Subjects With Alzheimer's Disease
NCT00934050
A Trial of TT223 in Patients With Type 2 Diabetes Who Are Taking Metformin and/or Thiazolidinedione
NCT00743002
ELND005 in Patients With Mild to Moderate Alzheimer's Disease
NCT00568776
Safety & Efficacy Study Evaluating the Combination of Bevasiranib & Lucentis Therapy in Wet AMD
NCT00499590
Safety and Efficacy of Topically Applied CTA018 in Plaque Psoriasis
NCT00384098
Safety and Efficacy Study of Small Interfering RNA Molecule (Cand5) to Treat Diabetic Macular Edema
NCT00306904
A Study in Type 2 Diabetic Patients With Repeated Doses of E1 in Combination With G1
NCT00239187
Safety and Efficacy Study of Small Interfering Ribonucleic Acid (RNA) Molecule (Cand5) to Treat Wet Age-Related Macular Degeneration
NCT00259753
A Study in Type 1 Diabetic Patients With Repeated Doses of E1 in Combination With G1
NCT00239148
Open Label Study for the Evaluation of Tolerability of Five Dose Levels of Cand5
NCT00722384
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 9 |
| Phase 2 | 18 |
| Phase 3 | 3 |
| Phase 4 | 1 |
Therapeutic Areas
What the Pipeline for OPKO Health Shows
According to the ClinicalTrials.gov registry, OPKO Health is linked to 32 US clinical trials across every stage of research activity. Of those, 0 studies are currently recruiting, about 0% of the sponsor's indexed portfolio, and 25 are already marked complete, representing roughly 78% of the total.
The phase mix for OPKO Health reports 4 late-stage studies (Phase 3 and Phase 4 combined) and 27 earlier-phase studies (Phase 1 and Phase 2).
The top therapeutic focus area indexed for OPKO Health is Growth Hormone Deficiency (GHD) with 1 linked trial, and 4 other condition areas appear in the top list above.
How to read these pipeline numbers
Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.