Nektar Therapeutics

37 total trials 1 currently recruiting 26 completed

Nektar Therapeutics sponsors 37 registered US clinical trials on ClinicalTrials.gov, 1 of them currently recruiting, and 26 completed. 7 of these trials are in Phase 3-4 (later-stage) and 30 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Breast Cancer, with 2 trials.

Trial Pipeline

37 total, page 1 of 1

RECRUITING Phase 3

A Phase 3 Study of Rezpegaldesleukin (NKTR-358) for Patients ≥ 12 Years of Age With Moderate-to-Severe Atopic Dermatitis

NCT07690371

ACTIVE NOT RECRUITING Phase 2

A Phase 2b Study to Evaluate Rezpegaldesleukin (Rezpeg) in the Treatment of Severe to Very Severe Alopecia Areata in Adult Patients (Rezolve AA)

NCT06340360

ACTIVE NOT RECRUITING Phase 2

A Phase 2b Study to Evaluate Rezpegaldesleukin (Rezpeg) in the Treatment of Adult Patients With Moderate-to-Severe Atopic Dermatitis

NCT06136741

TERMINATED Phase 2

NKTR-255 vs Placebo Following CD19-directed CAR-T Therapy in Patients With Relapsed/Refractory Large B-cell Lymphoma

NCT05664217

COMPLETED Phase 1

A Phase I Study of LY3471851 in Healthy Participants

NCT05565729

TERMINATED Phase 2

BEMPEG With Pembrolizumab vs Pembrolizumab Alone in Patients With Metastatic or Recurrent HNSCC (PROPEL-36)

NCT04969861

COMPLETED Phase 1

A Single-Dose Study of LY3471851 in Healthy Participants

NCT04998487

TERMINATED Phase 2

A Study of LY3471851 in Adult Participants With Moderately to Severely Active Ulcerative Colitis (UC)

NCT04677179

COMPLETED Phase 1

A Placebo Controlled Trial of Bempegaldesleukin (BEMPEG; NKTR-214) With Standard of Care in Patients With Mild COVID-19

NCT04646044

COMPLETED Phase 1

Study of NKTR 255 in Combination With Cetuximab in Solid Tumors

NCT04616196

COMPLETED Phase 2

A Study of LY3471851 in Adults With Systemic Lupus Erythematosus (SLE)

NCT04433585

TERMINATED Phase 3

Study to Compare Adjuvant Immunotherapy of Bempegaldesleukin Combined With Nivolumab Versus Nivolumab After Complete Resection of Melanoma in Patients at High Risk for Recurrence

NCT04410445

COMPLETED Phase 1

A Study of LY3471851 in Participants With Eczema

NCT04081350

COMPLETED Phase 1

A Study of LY3471851 in Participants With Psoriasis

NCT04119557

COMPLETED Phase 1

A Study of LY3471851 in Healthy Participants

NCT04133116

COMPLETED Phase 1

NKTR-255 in Relapsed/Refractory Multiple Myeloma & Non-Hodgkin Lymphoma

NCT04136756

COMPLETED Phase 2

A Single-Arm Study of Bempegaldesleukin (NKTR-214) Plus Nivolumab in Cisplatin Ineligible Patients Who Have Locally Advanced or Metastatic Urothelial Cancer

NCT03785925

TERMINATED Phase 3

A Study of Bempegaldesleukin (NKTR-214: BEMPEG) in Combination With Nivolumab Compared With the Investigator's Choice of a Tyrosine Kinase Inhibitor (TKI) Therapy (Either Sunitinib or Cabozantinib Monotherapy) for Advanced Metastatic Renal Cell Carcinoma (RCC)

NCT03729245

TERMINATED Phase 1

A Study Using fMRI Imaging to Evaluate the Effect of NKTR-181 on Brain Activity in Healthy, Non-physically Dependent Recreational Opioid Users.

NCT03802227

COMPLETED Phase 1

A Study of NKTR-358 (LY3471851) in Participants With Systemic Lupus Erythematosus (SLE)

NCT03556007

TERMINATED Phase 1

REVEAL Study of NKTR-262 in Combination With NKTR-214 and Nivolumab in Patients With Locally Advanced / Metastatic Solid Tumor Malignancies

NCT03435640

TERMINATED Phase 1

Bempegaldesleukin and Pembrolizumab With or Without Chemotherapy in Locally Advanced or Metastatic Solid Tumors

NCT03138889

COMPLETED Phase 1

A Study of NKTR-358 (LY3471851) in Healthy Participants

NCT04380324

COMPLETED Phase 1

A Dose Escalation and Cohort Expansion Study of NKTR-214 in Combination With Nivolumab and Other Anti-Cancer Therapies in Patients With Select Advanced Solid Tumors

NCT02983045

COMPLETED Phase 3

A Study of Etirinotecan Pegol (NKTR-102) Versus Treatment of Physician's Choice (TPC) in Patients With Metastatic Breast Cancer Who Have Stable Brain Metastases and Have Been Previously Treated With an Anthracycline, a Taxane, and Capecitabine

NCT02915744

COMPLETED Phase 1

A Phase 1/2 Multicenter Dose Escalation and Expansion Study Of NKTR-214 In Subjects With Locally Advanced Or Metastatic Solid Tumors

NCT02869295

COMPLETED Phase 3

Long-Term Safety and Tolerability Study of NKTR-181 in Subjects With Chronic Low Back Pain or Chronic Non-Cancer Pain

NCT02367820

COMPLETED Phase 3

Efficacy and Safety Study of NKTR-181 in Opioid-Naive Subjects With Low Back Pain

NCT02362672

COMPLETED Phase 1

A Study in Cancer Patients to Evaluate the Effect of a Single Dose of NKTR-102 (Etirinotecan Pegol) on the QTc Interval and to Assess Pharmacokinetics and Safety

NCT01976143

COMPLETED Phase 1

A Study in Cancer Patients With Hepatic Impairment to Evaluate the Pharmacokinetics and Safety of NKTR-102 (Etirinotecan Pegol)

NCT01991678

COMPLETED Phase 2

A Phase 2 Study To Assess The Efficacy, Tolerability, And Safety OF NKTR-181 In Subjects With Chronic OA Knee Pain

NCT01619839

COMPLETED Phase 3

The BEACON Study (Breast Cancer Outcomes With NKTR-102)

NCT01492101

COMPLETED Phase 2

An Extension Study of NKTR-102 in Cancer Patients Previously Enrolled in NKTR-102 Studies

NCT01457118

COMPLETED Phase 2

NKTR-102 Versus Irinotecan in Patients With Second-Line, Irinotecan-Naïve, KRAS Mutant, Colorectal Cancer

NCT00856375

COMPLETED Phase 2

Study to Evaluate the Safety and Efficacy of NKTR-102 in Patients With Metastatic or Locally Advanced Breast Cancer

NCT00802945

COMPLETED Phase 2

Study to Evaluate the Safety and Efficacy of NKTR-102 in Patients With Metastatic or Locally Advanced Ovarian Cancer

NCT00806156

COMPLETED Phase 2

NKTR-102 in Combination With Cetuximab in Patients With Refractory Solid Tumors (Phase 2a) and Metastatic or Locally Advanced Colorectal Cancer (Phase 2b)

NCT00598975

Phase Distribution

PhaseTrial count
Phase 1 17
Phase 2 13
Phase 3 7

What the Pipeline for Nektar Therapeutics Shows

According to the ClinicalTrials.gov registry, Nektar Therapeutics is linked to 37 US clinical trials across every stage of research activity. Of those, 1 studies are currently recruiting, about 3% of the sponsor's indexed portfolio, and 26 are already marked complete, representing roughly 70% of the total.

The phase mix for Nektar Therapeutics reports 7 late-stage studies (Phase 3 and Phase 4 combined) and 30 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for Nektar Therapeutics is Breast Cancer with 2 linked trials, and 6 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.