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COMPLETED Phase 3

A Study of Etirinotecan Pegol (NKTR-102) Versus Treatment of Physician's Choice (TPC) in Patients With Metastatic Breast Cancer Who Have Stable Brain Metastases and Have Been Previously Treated With an Anthracycline, a Taxane, and Capecitabine

NCT02915744 · View on ClinicalTrials.gov ↗

Study Summary

This is an open-label, randomized, active comparator, multicenter, international Phase 3 study of NKTR-102 versus TPC in patients with metastatic breast cancer who have stable brain metastases and have been previously treated with an anthracycline, a taxane, and capecitabine in either the adjuvant or metastatic setting (prior anthracycline may be omitted if medically appropriate or contraindicated for the patient).

Conditions Studied

Interventions

  • DRUG Gemcitabine
  • DRUG Eribulin
  • DRUG Vinorelbine
  • DRUG Ixabepilone
  • DRUG NKTR-102

Study Locations (20)

Florida

  • Investigator Site - Miami — Miami
  • Investigator Site - Plantation — Plantation
  • Investigator Site - West Palm Beach — West Palm Beach

California

  • Investigator Site - Orange — Orange
  • Investigator Site - San Francisco — San Francisco

Texas

  • Investigator Site - Fort Worth — Fort Worth
  • Investigator Site - Houston — Houston

Arizona

  • Investigator Site - Tucson — Tucson

Georgia

  • Investigator Site - Athens — Athens

Maryland

  • Investigator Site - Baltimore — Baltimore

Massachusetts

  • Investigator Site - Boston — Boston

Minnesota

  • Investigator Site - Minneapolis — Minneapolis

Trial Details

FieldValue
Enrollment Target 178 participants
Start Date 2016-11
Est. Completion 2020-07
Phase Phase 3

Sponsor

Nektar Therapeutics

6 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02915744

The ClinicalTrials.gov registry entry for NCT02915744 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 178 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Nektar Therapeutics, which has 6 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Breast Cancer appearing as the primary indexed condition, and to 5 interventions — of which Gemcitabine is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02915744 reports 20 study locations spanning 16 distinct geographic areas — top geographies include Florida, California, Texas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02915744 about?

NCT02915744 is a clinical study titled "A Study of Etirinotecan Pegol (NKTR-102) Versus Treatment of Physician's Choice (TPC) in Patients With Metastatic Breast Cancer Who Have Stable Brain Metastases and Have Been Previously Treated With an Anthracycline, a Taxane, and Capecitabine". This is an open-label, randomized, active comparator, multicenter, international Phase 3 study of NKTR-102 versus TPC in patients with metastatic breast cancer who have stable brain metastases and have been previously treated with an anthracycline, a taxane, and capecitabine in either the adjuvant o...

What is the current status of trial NCT02915744?

This trial is currently completed. It is a Phase 3 study. The enrollment target is 178 participants. The study started on 2016-11. Estimated completion is 2020-07.

What conditions does trial NCT02915744 study?

This clinical trial studies the following conditions: Breast Cancer, Metastasis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02915744?

The interventions under investigation include: Gemcitabine (DRUG), Eribulin (DRUG), Vinorelbine (DRUG), Ixabepilone (DRUG), NKTR-102 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02915744?

This trial is sponsored by Nektar Therapeutics, which has 6 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02915744 being conducted?

This trial has 20 study locations across Arizona, California, Florida, Georgia, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial