Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

ACTIVE NOT RECRUITING Phase 2

A Phase 2b Study to Evaluate Rezpegaldesleukin (Rezpeg) in the Treatment of Adult Patients With Moderate-to-Severe Atopic Dermatitis

NCT06136741 · View on ClinicalTrials.gov ↗

Study Summary

This is an interventional, randomized, parallel group, treatment, Phase IIb, double blind, 4-arm study to assess the effect of pegylated-recombinant-human interleukin-2 (rezpegaldesleukin) in adult participants with moderate to severe atopic dermatitis. The estimated duration is 15-35 days for screening, an Induction Period of 16 weeks, a Maintenance Period from Week 16-Week 52, and a Posttreatment Follow-Up Period for an additional year up to approximately Week 104 for all patients. Patients with a response at Week 16 (end of induction therapy) will be re-randomized for the maintenance therapy period.

Interventions

  • DRUG Placebo
  • DRUG Rezpegaldesleukin

Study Locations (20)

Florida

  • Nektar Investigative Site — Hialeah
  • Nektar Investigative Site — Hollywood
  • Nektar Investigative Site — Miami
  • Nektar Investigative Site — Miami Lakes
  • Nektar Investigative Site — St. Petersburg
  • Nektar Investigative Site — Tampa

California

  • Nektar Investigative Site — Fountain Valley
  • Nektar Investigative Site — Los Angeles
  • Nektar Investigative Site — Los Angeles
  • Nektar Investigative Site — Los Angeles
  • Nektar Investigative Site — Santa Monica

Indiana

  • Nektar Investigative Site — Clarksville
  • Nektar Investigative Site — Indianapolis

Michigan

  • Nektar Investigative Site — Flint
  • Nektar Investigative Site — Troy

Arkansas

  • Nektar Investigative Site — Bryant

Georgia

  • Nektar Investigative Site — Marietta

Kentucky

  • Nektar Investigative Site — Louisville

Nevada

  • Nektar Investigative Site — Las Vegas

Trial Details

FieldValue
Enrollment Target 396 participants
Start Date 2023-11-15
Est. Completion 2026-12-31
Phase Phase 2

Sponsor

Nektar Therapeutics

6 total trials

Interested in This Trial?

Always speak with your doctor before enrolling in a clinical trial.

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06136741

The ClinicalTrials.gov registry entry for NCT06136741 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 396 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Nektar Therapeutics, which has 6 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Moderate to Severe Atopic Dermatitis appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06136741 reports 20 study locations spanning 9 distinct geographic areas — top geographies include Florida, California, Indiana. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06136741 about?

NCT06136741 is a clinical study titled "A Phase 2b Study to Evaluate Rezpegaldesleukin (Rezpeg) in the Treatment of Adult Patients With Moderate-to-Severe Atopic Dermatitis". This is an interventional, randomized, parallel group, treatment, Phase IIb, double blind, 4-arm study to assess the effect of pegylated-recombinant-human interleukin-2 (rezpegaldesleukin) in adult participants with moderate to severe atopic dermatitis. The estimated duration is 15-35 days for scre...

What is the current status of trial NCT06136741?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 396 participants. The study started on 2023-11-15. Estimated completion is 2026-12-31.

What conditions does trial NCT06136741 study?

This clinical trial studies the following conditions: Moderate to Severe Atopic Dermatitis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06136741?

The interventions under investigation include: Placebo (DRUG), Rezpegaldesleukin (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06136741?

This trial is sponsored by Nektar Therapeutics, which has 6 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06136741 being conducted?

This trial has 20 study locations across Arkansas, California, Florida, Georgia, Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial