National Institute on Aging (NIA)

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, National Institute on Aging (NIA) sits in the top decile of US sponsors by registered trial count (#209 of 15,742 sponsors by registered trial count).

131 total trials 12 currently recruiting 103 completed early-phase tilt top decile by trial count

National Institute on Aging (NIA): 131 sponsored US clinical trials, 12 recruiting.

National Institute on Aging (NIA) sponsors 131 registered US clinical trials on ClinicalTrials.gov, 12 of them currently recruiting, and 103 completed. 18 of these trials are in Phase 3-4 (later-stage) and 38 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Aging, with 7 trials.

Top-decile sponsor footprint

National Institute on Aging (NIA) ranks in the top decile of sponsors by registered trial count (#209 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

D 62/100

103 of 116 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (88.8%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

131 total, page 2 of 3

COMPLETED NA

Memory Aid for Informed Consent in Alzheimer's Research

NCT00105612

COMPLETED

Serum, Dietary and Supplemental Vitamin D's Association With Cognitive Decline

NCT03320109

COMPLETED NA

Comparison of an Easy to Read Advance Directive Versus a Standard Advance Directive

NCT00328055

COMPLETED NA

Sleepiness and the Risk of Falling

NCT00383357

TERMINATED Phase 2

Idiopathic Anemia of Aging (IAA)

NCT00104169

COMPLETED Phase 2

Bryostatin 1 and Rituximab in Treating Patients With B-Cell Non-Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia

NCT00087425

TERMINATED

Vascular Aging: The Link That Bridges Age to Atherosclerosis (The VALIDATE Study)

NCT00246493

COMPLETED NA

Age, Lifestyle, Muscle Mechanisms in Insulin Resistance

NCT00971594

COMPLETED Phase 2

Huperzine A in Alzheimer's Disease

NCT00083590

COMPLETED Phase 1

The LIFE Study: Lifestyle Interventions and Independence for Elders, Pilot

NCT00116194

COMPLETED

Fast Food Study: Assessment of the Effects of Fast-Food on Inflammatory Markers

NCT00233311

COMPLETED Phase 2

Effects of Aromatase Inhibition Versus Testosterone in Older Men With Low Testosterone: Randomized-Controlled Trial.

NCT00104572

COMPLETED Phase 2

Hormone Replacement Therapy (HRT) Website Tool

NCT00319072

COMPLETED Phase 2

The Effects of Metformin on Blood Vessel Structure and Function

NCT00105066

COMPLETED NA

ABC Trial: Awakening and Breathing Controlled

NCT00097630

COMPLETED

Lymphoma Follow-up

NCT00744120

COMPLETED

Effects of Hormonal Infertility Treatment on Cognition in Pre-Menopausal Women

NCT00113867

COMPLETED Phase 2

The TLC2 (Teaching Healthy Lifestyles to Caregivers 2)/CALM (Counseling Advice for Lifestyle Management) Study

NCT00131105

COMPLETED

Forearm Vascular Relaxation

NCT00182923

COMPLETED

Risk Evaluation and Education for Alzheimer's Disease (REVEAL) II

NCT00089882

COMPLETED

Early Markers of Cognitive Change and Alzheimer s Disease

NCT01867346

COMPLETED

The Genetic Characterization of Dementia

NCT01867359

TERMINATED

Early Markers of Alzheimer's Disease: Structural and Functional Brain Changes

NCT01867372

COMPLETED Phase 1

Analysis of Atropine and Propranolol Induced Changes

NCT00251602

COMPLETED

Salt Study: Inhibited Breathing Pattern and Sodium Inhibitors in Sodium Sensitivity of Blood Pressure

NCT00800228

COMPLETED

Screening Protocol to Evaluate Volunteers for NIA Approved Studies

NCT02091271

COMPLETED Phase 1

GIP: Glucose-dependent Insulinotropic Peptide

NCT00239707

COMPLETED

Studies of Heritable Disorders of Connective Tissue

NCT00270686

COMPLETED Phase 3

VITAL - VITamins to Slow ALzheimer's Disease (Homocysteine Study)

NCT00056225

TERMINATED

Osteoarthritis and Body Composition: Evaluation of Systematic Mediators

NCT00771082

COMPLETED Phase 3

Cholesterol Lowering Agent to Slow Progression (CLASP) of Alzheimer's Disease Study

NCT00053599

COMPLETED NA

Dietary Energy Restriction and Metabolic Aging in Humans

NCT00183027

COMPLETED Phase 2

HORMA: Hormonal Regulators of Muscle and Metabolism in Aging

NCT00183040

COMPLETED

MIRAGE: Multi-Institutional Research in Alzheimer's Genetic Epidemiology

NCT00239759

COMPLETED Phase 3

Effects of Dehydroepiandrosterone (DHEA) in Humans

NCT00182975

COMPLETED NA

The Immune Function Intervention Trial

NCT00548990

COMPLETED

Collection of Bone Marrow Aspirate From Volunteer Donors

NCT00183066

COMPLETED Phase 4

Treatment of Agitation/Psychosis in Dementia/Parkinsonism (TAP/DAP)

NCT00043849

COMPLETED Phase 1

CALERIE (Tufts) - Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy

NCT00099099

COMPLETED NA

CALERIE (PBRC, Baton Rouge) - Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy

NCT00099151

COMPLETED Phase 1

CALERIE (Washington University): Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy

NCT00099138

COMPLETED NA

Race, Menopause and Metabolism After Exercise and Diet

NCT00882141

COMPLETED NA

GRACE: Geriatric Resources for Assessment and Care of Elders

NCT00182962

COMPLETED Phase 2

Pioglitazone in Alzheimer Disease

NCT00982202

COMPLETED Phase 4

Testosterone Effects on Bone and Frailty

NCT00182871

COMPLETED Phase 3

Effect of Vitamin K on Age-Related Bone Loss and Vascular Calcification

NCT00183001

COMPLETED NA

The HIP Impact Protection Program (HIP PRO)

NCT00058864

COMPLETED Phase 3

A Comparison of Weighted Vest Exercise and Strength Training

NCT00158119

COMPLETED Phase 2

Shingles: Immune Effects of Tai Chi

NCT00118885

COMPLETED NA

Biologic Effects of Dehydroepiandrosterone (DHEA) in Humans

NCT00099697

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Phase Distribution

PhaseTrial count
Phase 1 18
Phase 2 20
Phase 3 14
Phase 4 4

What is open in the National Institute on Aging (NIA) pipeline

12 recruiting of 131 indexed (9% open); 103 completed (79%).

Phase mix: 18 late (III/IV) vs 38 early (I/II) (early-phase heavy).

Top condition: Aging (7 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

National Institute on Aging (NIA): open-pipeline peers nationwide

Peers matched on 131 registered trials and 9% open enrollment, not the therapeutic-area sidebar.

National Institute on Aging (NIA) sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 050100150 5%10%15%20%25% Total trials Recruiting share National Institute on Aging (NIA)Rhode Island HospitalGeorge Washington UniversityUniversity of Illinois at Urbana-ChampaignJazz PharmaceuticalsAlkermesDBV TechnologiesFlorida Gulf Coast UniversityGenfit
National Institute on Aging (NIA) sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

National Institute on Aging (NIA) sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 131 trials (± recruiting share)

Sponsors near 9% open enrollment (± trial volume)

What to do with this National Institute on Aging (NIA) page

131 registered trials is a research-attention snapshot, not an endorsement of National Institute on Aging (NIA) or any single study.

  • 12 of National Institute on Aging (NIA)'s trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Aging is the condition National Institute on Aging (NIA) studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Aging trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

National Institute on Aging (NIA) pipeline card: 131 registered trials from official public datasets.Report a data error.