Mayo Clinic

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, Mayo Clinic sits in the top decile of US sponsors by registered trial count (#2 of 15,751 sponsors by registered trial count).

2,844 total trials 544 currently recruiting 1816 completed early-phase tilt top decile by trial count

Mayo Clinic: 2,844 sponsored US clinical trials, 544 recruiting.

Mayo Clinic sponsors 2,844 registered US clinical trials on ClinicalTrials.gov, 544 of them currently recruiting, and 1,816 completed. 252 of these trials are in Phase 3-4 (later-stage) and 821 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Healthy, with 36 trials.

Top-decile sponsor footprint

Mayo Clinic ranks in the top decile of sponsors by registered trial count (#2 of 15,751 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Open and recent trials

2,844 total, page 28 of 57

COMPLETED Phase 1

Effect of Secretin in Functional Dyspepsia and Healthy Subjects

NCT03617861

COMPLETED NA

Body Weight-Based Interval Training in Sedentary Overweight and Obese Adults

NCT03524521

COMPLETED NA

A Home-based Intervention to Promote Mindful Breathing Awareness Through Pursed-lip Breathing Training for COPD Patients

NCT03814980

COMPLETED Early Phase 1

Effects of Niacin on Intramyocellular Fatty Acid Trafficking in Upper Body Obesity and Type 2 Diabetes Mellitus

NCT03867500

TERMINATED NA

Evaluation of Magseed as Localization Device for Biopsy Proven Metastatic Axillary Lymph Nodes

NCT03718455

COMPLETED Phase 4

Liposomal Bupivacaine Interscalene Nerve Block in Shoulder Arthroplasty

NCT03663283

TERMINATED Phase 1

Autologous, Culture-Expanded Mesenchymal Stromal Cells for Degenerative Disc Disease

NCT03461458

COMPLETED NA

Using Pharmacogenetics to Identify Patients With Polypharmacy at Risk of Medication Adverse Effects

NCT03748355

COMPLETED NA

Genomic Opioid Optimization of Dosing and Selections (GOODS) Study

NCT03579121

COMPLETED Phase 4

Apremilast for RAS

NCT03690544

COMPLETED

Decision Aids for Patients With Nonvalvular Chronic Atrial Fibrillation (DA4AFib)

NCT03744936

TERMINATED

Institutional Outcome Data From Per-oral Plication of the Esophagus

NCT03875365

COMPLETED Phase 1

Topical Antibiotics in Chronic Rhinosinusitis

NCT03673956

COMPLETED Early Phase 1

Ketoconazole in Treating Participants With Ongoing EGFR Inhibitor-Induced Rash

NCT03471364

COMPLETED NA

Biomarkers in Repetitive Transcranial Magnetic Stimulation (rTMS) for Adolescent Depression

NCT03363919

COMPLETED Phase 2

Regional Prophylactic Vancomycin With Restricted Tourniquet Time in Primary Total Knee Replacement

NCT03506347

COMPLETED Phase 2

Avelumab in Combination With Fluorouracil and Mitomycin or Cisplatin and Radiation Therapy in Treating Participants With Muscle-Invasive Bladder Cancer

NCT03617913

COMPLETED Phase 1

REcycled CartiLage Auto/Allo IMplantation

NCT03672825

COMPLETED NA

Critical Care and Palliative Care Medicine Together in the ICU

NCT03520023

COMPLETED

Ventricular and Pulmonary Vascular Reserve After the Fontan Operation

NCT03853837

COMPLETED Phase 4

Gene Signatures of Influenza Vaccine Responses in Older Adults

NCT03603509

TERMINATED NA

Advancing Pre-operative Targeting for Deep Brain Stimulation in the Globus Pallidus Internus

NCT03600740

COMPLETED NA

Intravital Microscopy (IVM) in Patients With Peritoneal Carcinomatosis (PC)

NCT03517852

TERMINATED Phase 2

Ibrutinib and Ixazomib Citrate in Treating Newly Diagnosed, Relapsed or Refractory Waldenstrom Macroglobulinemia

NCT03506373

COMPLETED Phase 4

Lidocaine Jelly for Pain Control During Mohs Surgery

NCT03595449

COMPLETED NA

Acupuncture in Adolescent Football Players

NCT03478800

TERMINATED Phase 1

Anetumab Ravtansine and Atezolizumab in Treating Participants With Advanced Non-small Cell Lung Cancer

NCT03455556

COMPLETED NA

Authentic Connections for Nurse Leaders

NCT03616756

COMPLETED

Active Older Adult Program on Health and Well-being

NCT04897373

COMPLETED

Hypersensitivity Reactions During Anesthesia

NCT04125420

COMPLETED

Imaging Response to Immunotherapy and Radiation Therapy in Patients With Liver Metastases

NCT03401814

COMPLETED Phase 1

Midodrine in Hepatopulmonary Syndrome

NCT03600870

COMPLETED NA

Neuromuscular Intervention Targeted to Mechanisms of ACL Load in Female Athletes

NCT03190889

COMPLETED NA

Respiratory Muscle Contribution to Blood Pressure During Exercise

NCT03514823

TERMINATED NA

RSA vs. Nonop for 3 & 4-Part Proximal Humerus Fractures

NCT03599336

COMPLETED

Bone Health in Patients With Atopic Dermatitis

NCT03800004

COMPLETED Phase 2

Lidocaine as an Endotracheal Tube (ETT) Cuff Media

NCT03343080

COMPLETED NA

Acupuncture Treatment for Patients Who Develop Arrhythmias in the Post-Operative Cardio-Thoracic Setting

NCT03525860

COMPLETED NA

Investigating Magnesium Glycinate in Structure/Function Role of Hot Flashes.

NCT03564665

COMPLETED Phase 1

Pediatric MSC-AFP Sub-study for Crohn's Fistula

NCT03449069

COMPLETED Phase 4

d68Ga-DOTATATE PET/CT Assessment of Cardiac Sarcoidosis

NCT03549598

COMPLETED NA

Stress Management and Resilience Training (SMART) Intervention for Family Caregivers of Individuals With Advanced Cancer

NCT03565757

COMPLETED NA

Enteral Nutrition Tolerance and the Gut Microbiome Study

NCT03795870

COMPLETED NA

Mechanistic Effects of Health Coaching to Reduce Chronic Obstructive Pulmonary Disease (COPD) Hospitalizations

NCT03837847

TERMINATED

Study of Proton SBRT and Immunotherapy for Recurrent/Progressive Locoregional or Metastatic Head and Neck Cancer

NCT03539198

COMPLETED NA

Treatment of Dermatofibrosarcoma Protuberans in Patients 10 Years and Younger

NCT03381846

COMPLETED Phase 1

Myeloperoxidase (MPO) Inhibitor A_Zeneca for Heart Failure With Preserved Ejection Fraction (HFpEF)

NCT03611153

COMPLETED

A Prospective Clinical Trial Comparing Serum Mast Cell Tryptase (SMCT) Levels to Arthrofibrosis Rates Among Primary Total Knee Arthroplasty (TKA) Patients

NCT03598829

COMPLETED

Advanced Biomarker Assessment in Pelvic Organ Prolapse

NCT03642054

COMPLETED NA

Fluid Volume During Fluid Shifts

NCT03447574

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Phase Distribution

PhaseTrial count
Phase 1 435
Phase 2 386
Phase 3 86
Phase 4 166

What is open in the Mayo Clinic pipeline

544 recruiting of 2,844 indexed (19% open); 1,816 completed (64%).

Phase mix: 252 late (III/IV) vs 821 early (I/II) (early-phase heavy).

Top condition: Healthy (36 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.