Lexicon Pharmaceuticals

56 total trials 1 currently recruiting 51 completed

Lexicon Pharmaceuticals sponsors 56 registered US clinical trials on ClinicalTrials.gov, 1 of them currently recruiting, and 51 completed. 17 of these trials are in Phase 3-4 (later-stage) and 39 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Type 2 Diabetes Mellitus, with 3 trials.

Trial Pipeline

56 total, page 1 of 2

RECRUITING Phase 3

A Study to Evaluate the Efficacy and Safety of Sotagliflozin in Symptomatic Obstructive and Non-obstructive Hypertrophic Cardiomyopathy

NCT06481891

COMPLETED Phase 2

A Dose-ranging Study in Patients With Diabetic Peripheral Neuropathic Pain (DPNP)

NCT06203002

COMPLETED Phase 2

Efficacy and Safety of LX9211 in Participants With Postherpetic Neuralgia

NCT04662281

COMPLETED Phase 2

Efficacy, Safety, and PK of LX9211 in Participants With Diabetic Peripheral Neuropathic Pain

NCT04455633

TERMINATED Phase 3

Effect of Sotagliflozin on Cardiovascular Events in Participants With Type 2 Diabetes Post Worsening Heart Failure (SOLOIST-WHF Trial)

NCT03521934

TERMINATED Phase 3

Efficacy and Bone Safety of Sotagliflozin 400 and 200 mg Versus Placebo in Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control

NCT03386344

TERMINATED Phase 3

Effect of Sotagliflozin on Cardiovascular and Renal Events in Participants With Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk

NCT03315143

TERMINATED Phase 2

Safety, Tolerability and Pharmacodynamic Activity of Sotagliflozin in Hemodynamically Stable Participants With Worsening Heart Failure

NCT03292653

COMPLETED Phase 3

Efficacy and Safety of Sotagliflozin Versus Glimepiride and Placebo in Participants With Type 2 Diabetes Mellitus That Are Taking Metformin Monotherapy

NCT03332771

COMPLETED Phase 1

Study to Evaluate the Pharmacokinetics of Telotristat Ethyl in Subjects With Severe Hepatic Impairment

NCT03423446

COMPLETED Phase 3

Efficacy and Safety of Sotagliflozin Versus Placebo and Empagliflozin in Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control While Taking a DPP4 Inhibitor Alone or With Metformin

NCT03351478

COMPLETED Phase 1

A Phase 1 Study to Evaluate the Effects of Omeprazole and Famotidine on the Absorption of Telotristat Ethyl in Healthy Subjects

NCT03302845

COMPLETED Phase 3

Efficacy and Safety of Sotagliflozin Versus Placebo in Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control While Taking Insulin Alone or With Other Oral Antidiabetic Agents

NCT03285594

COMPLETED Phase 3

Safety and Efficacy Study of Sotagliflozin on Glucose Control in Participants With Type 2 Diabetes, Moderate Impairment of Kidney Function, and Inadequate Blood Sugar Control

NCT03242252

COMPLETED Phase 3

A Study to Evaluate Safety and Effects of Sotagliflozin 400 and 200 mg on Glucose Control in Participants With Type 2 Diabetes, Severe Impairment of Kidney Function and Inadequate Blood Sugar Control

NCT03242018

COMPLETED Phase 3

Efficacy and Safety of Sotagliflozin Versus Placebo in Participants With Type 2 Diabetes Mellitus on Background of Sulfonylurea Alone or With Metformin

NCT03066830

COMPLETED Phase 3

Efficacy and Safety of Sotagliflozin Versus Placebo in Patients With Type 2 Diabetes Mellitus Not Currently Treated With Antidiabetic Therapy

NCT02926937

COMPLETED Phase 3

Efficacy and Safety of Sotagliflozin Versus Placebo in Patients With Type 2 Diabetes Mellitus on Background of Metformin

NCT02926950

COMPLETED Phase 1

Study to Evaluate Sotagliflozin in Subjects With Varying Degrees of Renal Function

NCT02647918

COMPLETED Phase 3

A Phase 3 Study to Evaluate the Safety of Sotagliflozin in Patients With Type 1 Diabetes Who Have Inadequate Glycemic Control With Insulin Therapy Alone

NCT02531035

COMPLETED Phase 2

Dose-ranging Study in Patients With Type 1 Diabetes Mellitus

NCT02459899

COMPLETED Phase 1

PK Study of Sotagliflozin in Subjects With Hepatic Impairment

NCT02471274

COMPLETED Phase 2

Efficacy and Safety of Sotagliflozin in Young Adult Patients With Type 1 Diabetes Mellitus and Elevated Hemoglobin A1C

NCT02383940

COMPLETED Phase 3

Efficacy, Safety, and Tolerability Study of Sotagliflozin as Adjunct Therapy in Adult Patients With Type 1 Diabetes Mellitus Who Have Inadequate Glycemic Control With Insulin Therapy

NCT02384941

COMPLETED Phase 1

Bioequivalence Study Between 400 mg LX4211 Tablets and 2 X 200 mg LX4211 Tablets

NCT02373046

COMPLETED Phase 1

DDI Study With Multiple-dose LX4211 and Single Dose Rosuvastatin

NCT02300363

COMPLETED Phase 1

DDI Study With Multiple-dose LX4211 and Single Dose Digoxin

NCT02300350

COMPLETED Phase 1

Phase 1, Open-label, Drug-drug Interaction Study With Octreotide Acetate Injection and Telotristat Etiprate in Healthy Subjects

NCT02195635

COMPLETED Phase 1

An Open-Label Drug-Drug Interaction Study of Telotristat Etiprate and Fexofenadine in Healthy Subjects

NCT02157558

COMPLETED Phase 1

An Open-Label Food Effect Study of Telotristat Etiprate

NCT02157584

COMPLETED Phase 1

A Open-Label Drug-Drug Interaction Study of Telotristat Etiprate and Midazolam in Healthy Subjects

NCT02147808

COMPLETED Phase 1

A Thorough QT Study of Telotristat Etiprate

NCT02155205

COMPLETED Phase 3

Telotristat Etiprate for Carcinoid Syndrome Therapy

NCT02063659

COMPLETED Phase 3

Telotristat Etiprate - Expanded Treatment for Patients With Carcinoid Syndrome Symptoms

NCT02026063

COMPLETED Phase 1

Study to Determine the Safety, Tolerability and Pharmacokinetics Following Multiple Doses of LX4211 in Healthy Subjects

NCT01916850

COMPLETED Phase 1

Study to Evaluate the Effect of Single Doses of LX4211 and Canagliflozin on Intestinal Glucose Absorption in Healthy Adult Subjects

NCT01916863

COMPLETED Phase 1

Study to Define the Electrocardiogram Effects of a Single Dose of LX4211 in Healthy Subjects

NCT01913002

COMPLETED Phase 1

Study to Determine the Absorption, Metabolism, and Excretion of [14C]LX4211 in Healthy Male Subjects

NCT01818232

COMPLETED Phase 2

Safety and Efficacy of Sotagliflozin (LX4211) in Patients With Inadequately Controlled Type 1 Diabetes Mellitus

NCT01742208

COMPLETED Phase 3

TELESTAR (Telotristat Etiprate for Somatostatin Analogue Not Adequately Controlled Carcinoid Syndrome)

NCT01677910

COMPLETED Phase 1

Study to Evaluate the Safety, Tolerability, and Efficacy of LX7101 in Subjects With Primary Open-angle Glaucoma or Ocular Hypertension

NCT01528111

COMPLETED Phase 1

Study to Evaluate the Pharmacodynamic and Pharmacokinetic Effects of LX4211 in Subjects With Type 2 Diabetes and Renal Impairment

NCT01555008

COMPLETED Phase 2

A Multi-Center Trial to Determine the Safety and Efficacy of LX1033 in Subjects With Diarrhea-Predominant Irritable Bowel Syndrome

NCT01494233

COMPLETED Phase 2

A Study to Evaluate Safety and Efficacy of Telotristat Etiprate (LX1606) in Participants With Acute, Mild to Moderate Ulcerative Colitis

NCT01456052

COMPLETED Phase 1

A Study to Evaluate the Pharmacodynamic Effects of Single-Dose Co-Administration of LX4211 With Januvia® in Type 2 Diabetics

NCT01441232

COMPLETED Phase 1

A Study to Determine the Safety and Efficacy of LX3305 in Subjects With Active Rheumatoid Arthritis

NCT01417052

COMPLETED Phase 1

An Open-Label Study of Two Formulations of LX1033 in Healthy Human Subjects

NCT01411800

COMPLETED Phase 2

Safety and Efficacy of LX4211 With Metformin in Type 2 Diabetes Patients With Inadequate Glycemic Control on Metformin

NCT01376557

COMPLETED Phase 1

A Study to Determine the Pharmacodynamics of LX4211 Relative to Meals in Healthy Subjects

NCT01334242

COMPLETED Phase 1

A Study to Evaluate the Interaction of LX4211 and Metformin in Healthy Subjects

NCT01292993

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What the Pipeline for Lexicon Pharmaceuticals Shows

According to the ClinicalTrials.gov registry, Lexicon Pharmaceuticals is linked to 56 US clinical trials across every stage of research activity. Of those, 1 studies are currently recruiting, about 2% of the sponsor's indexed portfolio, and 51 are already marked complete, representing roughly 91% of the total.

The phase mix for Lexicon Pharmaceuticals reports 17 late-stage studies (Phase 3 and Phase 4 combined) and 39 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for Lexicon Pharmaceuticals is Type 2 Diabetes Mellitus with 3 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.