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NCT05924815 · ClinicalTrials.gov registry record · Phase 1
Study to Evaluate the Effect of Aficamten Administration on QT/QTc Interval
A Phase 1 study, sponsored by Cytokinetics.
- Completed
- Registry status
- Phase 1
- Development phase
- 44
- Enrollment target
NCT05924815: Completed Phase 1 study, sponsored by Cytokinetics.
NCT05924815 is a Phase 1 study that has completed, run by Cytokinetics. The registered enrollment target is 44 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (27% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05924815, a Phase 1 study, has completed, sponsored by Cytokinetics.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 44 participants
- Enrollment target
Study Summary
This is a single-center, 2-part (Part A and Part B) study in healthy participants. Part A (Dose Finding) is an open-label, SAD study to identify the dose for Part B. Part B (TQT Study) is a randomized, double-blind (with respect to aficamten and matching placebo), positive- and placebo-controlled, single-dose, 3-way crossover study to evaluate the effect of aficamten administration on QT/QTc interval.
Primary Outcome
To determine the dose for Part B based on Part A PK and safety data.
Interventions
- DRUG Moxifloxacin
- DRUG Aficamten
- DRUG Aficamten-matching Placebo
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 44 participants |
| Start Date | 2023-05-15 |
| Est. Completion | 2023-11-14 |
| Phase | Phase 1 |
What the finished NCT05924815 record still lists
NCT05924815 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 44 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (27% lower).
The record links to 0 conditions, and to 3 interventions - of which Moxifloxacin is the first listed.
NCT05924815 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05924815 about?
NCT05924815 is a clinical study titled "Study to Evaluate the Effect of Aficamten Administration on QT/QTc Interval". This is a single-center, 2-part (Part A and Part B) study in healthy participants. Part A (Dose Finding) is an open-label, SAD study to identify the dose for Part B. Part B (TQT Study) is a randomized, double-blind (with respect to aficamten and matching placebo), positive- and placebo-controlled, s...
What is the current status of trial NCT05924815?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 44 participants. The study started on 2023-05-15. Estimated completion is 2023-11-14.
What interventions are being tested in trial NCT05924815?
The interventions under investigation include: Moxifloxacin (DRUG), Aficamten (DRUG), Aficamten-matching Placebo (DRUG).
Who is sponsoring clinical trial NCT05924815?
This trial is sponsored by Cytokinetics, which has 31 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05924815's enrollment target sits among peer trials
44 1086th of 2000 higher than 901 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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