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NCT03767855 · ClinicalTrials.gov registry record · Phase 1
A Single and Multiple Ascending Dose Study of CK-3773274 in Healthy Adult Subjects
A Phase 1 study, sponsored by Cytokinetics.
- Completed
- Registry status
- Phase 1
- Development phase
- 114
- Enrollment target
NCT03767855: Completed Phase 1 study, sponsored by Cytokinetics.
NCT03767855 is a Phase 1 study that has completed, run by Cytokinetics. The registered enrollment target is 114 participants, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (90% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03767855, a Phase 1 study, has completed, sponsored by Cytokinetics.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 114 participants
- Enrollment target
Study Summary
The purposes of this study are to: 1. Learn about the safety of CK-3773274 after a single dose and multiple doses in healthy subjects. 2. Learn how healthy subjects tolerate CK-3773274 after a single dose and multiple doses. 3. Find out how much CK-3773274 is in the blood after a single dose and multiple doses. 4. Determine the effect of doses of CK-3773274 on the pumping function of the heart. 5. Evaluate the effect of cytochrome genetic variants on how the body metabolizes CK-3773274. 6. Evaluate the effect of a meal on how much CK-3773274 is in the blood in healthy adult subjects. 7. Evaluate whether the amount of CK-3773274 in the blood is the similar for both the tablet and granules in capsule forms of the drug.
Primary Outcome
Subject incidence of AEs, SAEs, and reduced LVEF
Interventions
- DRUG CK-3773274 - Granules in Capsule
- DRUG Placebo - Granules in Capsule
- DRUG CK-3773274 - Tablets
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 114 participants |
| Start Date | 2018-12-04 |
| Est. Completion | 2020-01-03 |
| Phase | Phase 1 |
What the finished NCT03767855 record still lists
NCT03767855 is an interventional study that assigns participants to a tested intervention. The registered 114 participants enrollment target is mid-sized for trials with a published cap, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (90% higher).
The record links to 0 conditions, and to 3 interventions - of which CK-3773274 - Granules in Capsule is the first listed.
NCT03767855 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03767855 about?
NCT03767855 is a clinical study titled "A Single and Multiple Ascending Dose Study of CK-3773274 in Healthy Adult Subjects". The purposes of this study are to: 1. Learn about the safety of CK-3773274 after a single dose and multiple doses in healthy subjects. 2. Learn how healthy subjects tolerate CK-3773274 after a single dose and multiple doses. 3. Find out how much CK-3773274 is in the blood after a single dose and mu...
What is the current status of trial NCT03767855?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 114 participants. The study started on 2018-12-04. Estimated completion is 2020-01-03.
What interventions are being tested in trial NCT03767855?
The interventions under investigation include: CK-3773274 - Granules in Capsule (DRUG), Placebo - Granules in Capsule (DRUG), CK-3773274 - Tablets (DRUG).
Who is sponsoring clinical trial NCT03767855?
This trial is sponsored by Cytokinetics, which has 31 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03767855's enrollment target sits among peer trials
114 507th of 2000 higher than 1,493 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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