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NCT04219826 · ClinicalTrials.gov registry record · Phase 2
Dose-finding Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CK-3773274 in Adults With Hypertrophic Cardiomyopathy
A Phase 2 study, sponsored by Cytokinetics.
- Completed
- Registry status
- Phase 2
- Development phase
- 96
- Enrollment target
NCT04219826: Completed Phase 2 study, sponsored by Cytokinetics.
NCT04219826 is a Phase 2 study that has completed, run by Cytokinetics. The registered enrollment target is 96 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (28% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04219826, a Phase 2 study, has completed, sponsored by Cytokinetics.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 96 participants
- Enrollment target
Study Summary
This study is being performed to understand the effect of different doses of CK-3773274 on patients with hypertrophic cardiomyopathy (HCM).
Primary Outcome
Participant incidence of reported AEs to determine the safety and tolerability of aficamten in participants with HCM.
Interventions
- DRUG CK-3773274 (5 - 15 mg)
- DRUG CK-3773274 (10 - 30 mg)
- DRUG Placebo for CK-3773274
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 96 participants |
| Start Date | 2020-01-10 |
| Est. Completion | 2023-02-28 |
| Phase | Phase 2 |
What the finished NCT04219826 record still lists
NCT04219826 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 96 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (28% lower).
The record links to 0 conditions, and to 3 interventions - of which CK-3773274 (5 - 15 mg) is the first listed.
NCT04219826 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04219826 about?
NCT04219826 is a clinical study titled "Dose-finding Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CK-3773274 in Adults With Hypertrophic Cardiomyopathy". This study is being performed to understand the effect of different doses of CK-3773274 on patients with hypertrophic cardiomyopathy (HCM).
What is the current status of trial NCT04219826?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 96 participants. The study started on 2020-01-10. Estimated completion is 2023-02-28.
What interventions are being tested in trial NCT04219826?
The interventions under investigation include: CK-3773274 (5 - 15 mg) (DRUG), CK-3773274 (10 - 30 mg) (DRUG), Placebo for CK-3773274 (DRUG).
Who is sponsoring clinical trial NCT04219826?
This trial is sponsored by Cytokinetics, which has 31 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04219826's enrollment target sits among peer trials
96 747th of 2000 higher than 1,242 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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