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NCT00748579 · ClinicalTrials.gov registry record · Phase 2
Phase II Study of the Effect of CK-1827452 Injection on Myocardial Efficiency
A Phase 2 study, sponsored by Cytokinetics.
- Terminated
- Registry status
- Phase 2
- Development phase
- 2
- Enrollment target
NCT00748579: Clinical Trial Phase 2 study, sponsored by Cytokinetics.
NCT00748579 is a Phase 2 study that was terminated before completion, run by Cytokinetics. The registered enrollment target is 2 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00748579, a Phase 2 study, was terminated before completion, sponsored by Cytokinetics.
- TERMINATED
- Registry status
- Phase 2
- Development phase
- 2 participants
- Enrollment target
Study Summary
The purpose for this study (CY 1124) is to evaluate the effects of CK-1827452, a cardiac myosin activator, on myocardial systolic performance, myocardial oxygen consumption, and myocardial efficiency in patients with heart failure and to confirm that the unique preclinical pharmacological profile of CK- 1827452 is substantially the same in patients with heart failure.
Primary Outcome
Measure the effect CK-1827452 on hemodynamics and energetic measures of ventricular performance, myocardial oxygen consumption, and myocardial efficiency (the ratio of ventricular performance to myocardial oxygen consumption), in patients with clinical heart failure.
Interventions
- DRUG CK-1827452
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2 participants |
| Start Date | 2008-09 |
| Est. Completion | 2009-07 |
| Phase | Phase 2 |
Why NCT00748579 stopped before completion
NCT00748579 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 2 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 1 intervention - of which CK-1827452 is the first listed.
NCT00748579 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00748579 about?
NCT00748579 is a clinical study titled "Phase II Study of the Effect of CK-1827452 Injection on Myocardial Efficiency". The purpose for this study (CY 1124) is to evaluate the effects of CK-1827452, a cardiac myosin activator, on myocardial systolic performance, myocardial oxygen consumption, and myocardial efficiency in patients with heart failure and to confirm that the unique preclinical pharmacological profile of...
What is the current status of trial NCT00748579?
This trial is currently terminated. It is a Phase 2 study. The enrollment target is 2 participants. The study started on 2008-09. Estimated completion is 2009-07.
What interventions are being tested in trial NCT00748579?
The interventions under investigation include: CK-1827452 (DRUG).
Who is sponsoring clinical trial NCT00748579?
This trial is sponsored by Cytokinetics, which has 31 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00748579's enrollment target sits among peer trials
2 2001st of 2000 the lowest of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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