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Venous Leg Ulcer clinical trials
Every US clinical trial registered for Venous Leg Ulcer — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
36 US clinical trials · 20 currently recruiting
The research picture
Venous Leg Ulcer has 36 registered US clinical trials, 20 of them open to new participants right now — about 56% of the total.
- 20
- recruiting participants now
- 56%
- of trials open to enrollment
- 8
- in Phase 3–4 (later-stage)
- 3
- top sponsor: BioLab Holdings
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Trial Assessing the Efficacy of Human Placental Membrane Products and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg Ulcers
BioLab Holdings
NCT07089602
A Modified Platform Trial of Multiple CAMPs for the Management of Diabetic Foot Ulcers and Venous Leg Ulcers
Integra LifeSciences Corporation
NCT06453187
Evaluating Several Cellular, Acellular, and Matrix-like Products (CAMPs) and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot and Venous Leg Ulcers.
Tiger Biosciences
NCT06826339
Modified Multi-Platform Trial Assessing Multiple CAMPs and SOC vs SOC Alone in the Treatment of DFU and VLUs
Stability Biologics
NCT06560502
Tissue Repair Gel in Venous Leg Ulcers in AU/US
TR Therapeutics
NCT06707103
Tissue Repair Gel in Venous Leg Ulcers (US)
TR Therapeutics
NCT06707090
Study Assessing Complete Wound Healing by Comparing Surgenex® PelloGraft in Treating DFU and SanoGraft® in Treating VLU to SOC
Surgenex
NCT06515093
Real World Evidence with the Debritom+ TM Novel Micro Water Jet Technology At a Single Wound Center
Medaxis
NCT04920253
The GORE® VIABAHN® FORTEGRA Venous Stent Iliofemoral Study
W.L.Gore & Associates
NCT05489588
CAMP RWE Trial: Amnion Grafts for Healing Hard-to-Heal Ulcers in RW Populations
Capsicure
NCT07046767
Human Amniotic Membrane On Venous Leg Ulcers In an Elderly Population
BioLab Holdings
NCT06544564
Evaluating the Durability of Closure for Venous Leg Ulcers
Kerecis
NCT06697925
INNOVEN: Efficacy of Porcine Placental Extracellular Matrix Plus Standard of Care (SOC) Versus SOC Alone
ConvaTec
NCT06606210
A Clinical Investigation to Follow the Progress of Exuding Chronic Wounds Using Mepilex® Up as the Primary Dressing.
Molnlycke Health Care AB
NCT05588583
Non-healing Venous Leg Ulcers Treated With Standard Care With or Without BR-AC
BioStem Technologies
NCT06811909
A Multicenter, Prospective, Controlled Modified Multi-Platform Trial Assessing the Efficacy of Human Placental Membrane Products and Standard of Care in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg Ulcers.
BioLab Holdings
NCT07364630
Dermacyte® Amniotic Wound Care Liquid for the Treatment of Non-Healing Venous Stasis Ulcers
Merakris Therapeutics
NCT04647240
Randomized Controlled Trial for Treatment of Pain and Assessment of Wound Healing in Chronic Venous Leg Ulcers Using Near Infrared Laser Therapy
Wake Forest University Health Sciences
NCT03716167
A Clinical Investigation to Follow the Progress of Exuding Chronic Venous Leg Ulcers Using a Non-Bordered Foam Dressing
Molnlycke Health Care AB
NCT05608317
Prospective Case Series Evaluating the Efficacy and Safety of NeoThelium FT for Venous Leg Ulcers
NuScience Medical Biologics
NCT07061613
Geko™ Cross Therapy Registry - Wound
Firstkind
NCT05007301
Study Evaluating Several CAMPs in Nonhealing Diabetic Foot and Venous Leg Ulcers
Cellution Biologics
NCT06562296
Allogeneic ABCB5-positive Dermal Mesenchymal Stromal Cells for Treatment of Therapy-resistant CVU (Phase III)
RHEACELL GmbH & Co. KG
NCT06489028
Chronic Venous Thrombosis: Relief With Adjunctive Catheter-Directed Therapy (The C-TRACT Trial)
Washington University School of Medicine
NCT03250247
Developing Strategies for Effective Debridement in Patients for Venous Leg Ulcers
University of Miami
NCT03796793
The GORE® VIABAHN® FORTEGRA Venous Stent IVC Study
W.L.Gore & Associates
NCT05409976
Efficacy of TR 987, Beta-1,3-1,6-D-glucan, in the Treatment of Chronic Venous Insufficiency Ulcers
SerenaGroup
NCT03154619
Pivotal Trial of Dermagraft(R) to Treat Venous Leg Ulcers
Organogenesis
NCT00909870
Study to Evaluate Safety and Efficacy of GrafixPL for the Treatment of Venous Leg Ulcers
Osiris Therapeutics
NCT03629236
Intermittent Pneumatic Compression of the Thigh
Huntleigh Healthcare
NCT05659394
Dose-response Relationship Study of S42909 on Leg Ulcer Healing
Ilkos Therapeutic
NCT03077165
A Study to Evaluate the Safety and the Efficacy of EscharEx (EX-02 Formulation) in Debridement of Venous Leg Ulcers
MediWound
NCT03588130
Human Amniotic Membrane Grafting and Standard of Care Versus Standard of Care Alone in the Treatment of Venous Leg Ulcers
MiMedx Group
NCT01552447
Omeza Combination Therapy With Standard of Care to Standard of Care Alone for Chronic Venous Leg Ulcers
Omeza
NCT05291169
Evaluation of a Dual Action Pneumatic Compression System: Tolerance and Comfort in Patients With Venous Leg Ulcers (VLUs)
Tactile Medical
NCT02395302
Safety Study to Examine the Systemic Exposure of Granexin® Gel After Topical Application to Venous Leg Ulcers
Xequel Bio
NCT02652572
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 4 |
| Phase 3 | 4 |
| Phase 4 | 4 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Venous Leg Ulcer Trial Landscape
ClinicalTrials.gov lists 36 US studies indexed under Venous Leg Ulcer, and 20 of those are currently open to recruitment — roughly 56% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Venous Leg Ulcer shows 8 late-stage studies (Phase 3 and Phase 4 combined) alongside 5 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Venous Leg Ulcer is led by BioLab Holdings with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 36 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Venous Leg Ulcer?
PlainTrial tracks 36 US clinical trials for Venous Leg Ulcer, of which 20 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Venous Leg Ulcer?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.